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Jhon Evan Iskandar Manullang
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Dentistry Electrical & Electronics Engineering Energy Engineering Health Professions Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Uji Total Flavonoid dan Aktivitas Antioksidan Fraksi Daun Brotowali sebagai Diabetes Ulkus Jhon Evan Iskandar Manullang; Novitaria Br Sembiring; Astriani Natalia Br Ginting
INSOLOGI: Jurnal Sains dan Teknologi Vol. 5 No. 2 (2026): April 2026
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v5i2.7866

Abstract

Diabetic ulcers are a chronic complication of diabetes mellitus characterized by impaired wound healing due to increased oxidative stress. One therapeutic approach that can be developed is the use of medicinal plants with antioxidant activity, such as Tinospora crispa leaves (Tinospora crispa), which contain flavonoids. This study aimed to determine the total flavonoid content and antioxidant activity of Tinospora crispa leaf fractions. Extraction was carried out using 96% ethanol, followed by fractionation using n-hexane, ethyl acetate, and water. Flavonoid content was determined using UV-Vis spectrophotometry using quercetin as a standard at a wavelength of 430.5 nm, while antioxidant activity was tested using the DPPH method. The results showed that the Tinospora crispa leaf aqueous fraction contained flavonoids of 0.2179 mg QE/g, with a linear calibration curve (R² = 0.997). Furthermore, the aqueous fraction demonstrated very strong antioxidant activity with an IC₅₀ value of ±16 µg/mL. Based on these results, the water fraction of brotowali leaves has the potential to be a source of natural antioxidants that can support the healing of diabetic ulcers by suppressing oxidative stress.
Co-Authors Astriani Natalia Br Ginting Novitaria Br Sembiring