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All Journal Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan Jurnal Sains Farmasi dan Kesehatan Galen: Jurnal Ilmu Farmasi dan Kesehatan
Novitaria Br Sembiring
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Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Physics Public Health Veterinary

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Uji Efek Nefroprotektif Ekstrak Daun Kemangi (Ocimum Bacilicum L.) Terhadap Tikus Wistar Jantan Yang Diinduksi Aspirin Rizkya Adinda Nasution; Asyrun Alkhairi Lubis; Novitaria Br Sembiring
An-Najat Vol. 3 No. 2 (2025): Mei : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i2.2537

Abstract

The kidneys serve a vital function in maintaining homeostasis by filtering blood, excreting metabolic waste, and eliminating exogenous substances, including drugs and environmental toxins. However, prolonged or excessive exposure to certain chemicals, such as nonsteroidal anti-inflammatory drugs (NSAIDs) like aspirin, can result in nephrotoxicity and lead to significant renal damage. In the pursuit of alternative therapeutic agents with fewer side effects, natural compounds with antioxidant properties have gained increasing interest. Ocimum basilicum L., commonly known as sweet basil, is a medicinal plant traditionally used for various therapeutic purposes. Its leaves are rich in antioxidant compounds that are hypothesized to possess nephroprotective activity. This study aimed to investigate the protective effects of Ocimum basilicum leaf extract against aspirin-induced renal injury in experimental rats. The study involved dividing the rats into multiple groups: a control group, a group treated with aspirin only, and groups treated with aspirin followed by Ocimum basilicum leaf extract at different dosages (400, 600, and 800 mg/kg BW). Renal function was assessed via serum creatinine levels and histopathological analysis of kidney tissues. The results revealed that aspirin administration significantly increased serum creatinine levels and caused observable damage to kidney tissue, confirming nephrotoxicity. However, post-treatment with Ocimum basilicum extract, particularly at the highest dose of 800 mg/kg BW, markedly reduced serum creatinine levels and improved renal histological architecture. These findings indicate that Ocimum basilicum leaf extract has potential as a nephroprotective agent, capable of mitigating aspirin-induced kidney damage, likely through its antioxidant activity. Further research is warranted to explore its mechanism of action and potential clinical applications.
Analisis Interaksi Obat Antihipertensi pada Pasien di Rumah Sakit Umum Royal Prima Marelan Janice Tjandra; Razoki Lubis; Novitaria Br Sembiring
Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan Vol. 3 No. 2 (2025): Corona: Jurnal Ilmu Kesehatan Umum, Psikolog, Keperawatan dan Kebidanan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/corona.v3i2.1310

Abstract

Hypertension is a chronic disease that often attacks the elderly and can cause serious complications, including stroke and heart disease. This study aims to evaluate the use of antihypertensives and analyze drug interactions based on severity in hospitalized patients at RSU Royal Prima Marelan. The research method is descriptive retrospective of patient medical records in 2024. The results showed that the majority of patients were women (62.5%) aged 60–74 years (50%). The use of a combination of two antihypertensive drugs was most commonly found (40%), with the combination of amlodipine and candesartan being the most frequently used. The severity of the most drug interactions was in the moderate category (82.35%), followed by major (10.50%) and minor (7.14%). The most significant interactions occurred in the combination of candesartan and spironolactone (major), and amlodipine and bisoprolol (moderate).
Evaluasi Drug Related Problems (DRPs) pada Pasien Diabetes Melitus dengan Komplikasi Hipertensi Rawat Inap di RSU Royal Prima Marelan Herna Nurlaila Maulidia; Razoki; Novitaria Br Sembiring
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 1 No. 2 (2025): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v1i2.25

Abstract

Penelitian ini dilakukan untuk menilai kejadian Drug Related Problems (DRPs) pada pasien yang menderita diabetes melitus tipe 2 disertai komplikasi hipertensi yang dirawat inap di RSU Royal Prima Marelan. Metode: Penelitian yang digunakan bersifat deskriptif retrospektif, dengan analisis data rekam medis pasien selama periode Januari hingga Maret 2024. Jumlah subjek penelitian sebanyak 54 resep pada rekam medis, mayoritas berusia 50 tahun ke atas sebanyak 41 pasien (76%) dan berjenis kelamin Perempuan sebanyak 35 pasien (65%). Hasil: Dari hasil evaluasi ditemukan 58 kejadian DRPs, yang paling dominan berupa interaksi obat sebanyak 33 kejadian (57%), diikuti oleh penggunaan obat tanpa indikasi medis yang jelas sebanyak 12 kejadian (21%), efek samping obat sebanyak 7 kejadian (12%), serta ketidaktepatan dalam pemilihan obat sebanyak sebanyak 6 kejadian (10%). Kesimpulan: Hasil ini menunjukkan perlunya pemantauan terapi yang lebih ketat dan kolaborasi antar tenaga medis untuk mengurangi risiko DRPs.
Identifikasi Drug Related Problems Terhadap Pasien Hipertensi Di Rumah Sakit Royal Prima Marelan Yohanes Dewantoro Situmorang; Razoki, Razoki; Novitaria Br Sembiring
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

This study aims to assess Drug Related Problems (DRPs) in hypertensive patients hospitalized at Royal Prima Marelan General Hospital during the period January until June 2024. The study was conducted as a descriptive retrospective analysis on 33 patients using medical records and prescription data. The results showed that drug interactions were the most common DRPs (98,51%), with 64 cases classified as moderate severity, 37 as minor, and 12 as major. The most common interactions occurred with the combination of amlodipine and clopidogrel, while major interactions occurred with the combination of candesartan and spironolactone. Regular monitoring of potential drug interactions is crucial to support the safety and effectiveness of treatment.
Co-Authors Asyrun Alkhairi Lubis Herna Nurlaila Maulidia Janice Tjandra Razoki Razoki Lubis Razoki, Razoki Rizkya Adinda Nasution Yohanes Dewantoro Situmorang