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All Journal Jurnal Sains dan Teknologi Jurnal Rumpun Ilmu Kesehatan Jurnal Sains Student Research Jurnal Sains Farmasi dan Kesehatan Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Astriani Natalia Br Ginting
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Activity Test Of Salam Extract (Syzygium polyanthum) On Diabetes Disease Using White Rats (Ratus Novergicus) Hikmad Elsi Enoni Harefa; Astriani Natalia Br Ginting; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.2609

Abstract

Diabetes Mellitus is a chronic metabolic disease characterized by elevated blood sugar levels due to impaired secretion or action of insulin. The use of herbal plants such as as salam leaves (syzygium polyanthum) is one of the alternative treatment methods. This study aims to evaluate the effectiveness and optimal dosage of salam leaf extract in lowering blood glucose levels in male rats (Rattus Novergicus) induced by alloxan. A total of 30 rats we divided into six groups: normal control, negative control, positive control (metformin), and three treatment groups with extract doses of 200, 300, and 400 Mg/KgBB. Blood glucose levels were measured on days 15,20,25, and 30. Data were analyzed using ANOVA with a significance level of 95%. The results show that salam leaf extract significantly lowers blood glucose levels, with the most effective dose being 400 Mg/KgBB. This study supports the potential of salam leaves as an effective, safe, and affordable natural antidiabetic agent.
Evaluasi Kesesuaian Obat Dan Dosis Antihipertensi Pada Pasien Hipertensi Rawat Jalan Di Rumah Sakit Royal Prima Sosa Ester Kristiani Lase; Muhammad Yunus; Astriani Natalia Br Ginting
Jurnal Sains Farmasi Dan Kesehatan Vol. 3 No. 1 (2025): Mei - Agustus
Publisher : CV. ITTC INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62379/jfkes.v3i1.3252

Abstract

This study was conducted to assess the appropriateness of antihypertensive medication selection and dosage and to analyze the cost-efficiency of therapy in outpatients with hypertension at Royal Prima Hospital, Medan. This study used a retrospective descriptive method, with data collected from the medical records of 42 patients. Evaluation of therapy effectiveness and costs was conducted using a Cost-Effectiveness Analysis (AEB) approach, calculating the Average Cost-Effectiveness Ratio (ACER) and the Incremental Cost-Effectiveness Ratio (ICER). Symptoms associated with hypertension can be avoided by reducing excess weight (obesity), controlling salt intake, engaging in regular physical activity, quitting smoking, and taking medication regularly. A hypertension prevalence survey found that the prevalence of hypertension in Indonesia among the population aged 18 years and over is 31.3% for men and 31.9% for women, out of the total population aged 18 years and older. In 2008, the number of hypertension sufferers reached 32%, with the majority of patients aged > 25 years. The results showed that all patients (100%) received appropriate antihypertensive therapy based on standard clinical guidelines, both in terms of drug selection and dosage. The most commonly used drug combination was ARB and CCB, found in 23.81% of patients. The combination of a non-DHP CCB + ARB + ​​loop diuretic + alpha-blocker demonstrated the highest therapeutic effectiveness (100%) with the lowest average cost of IDR 680,000, thus being considered the most cost-effective regimen according to the ICER analysis. Meanwhile, several other therapy combinations that required higher costs but provided less effectiveness were categorized as cost-inefficient. These findings emphasize the importance of rational evaluation of antihypertensive therapy, particularly in terms of treatment appropriateness and cost-efficiency, to support optimal clinical outcomes and appropriate resource utilization.
Uji Efektivitas Gel Ekstrak Etanol Daun Asam Jawa dalam Proses Penyembuhan Luka Bakar pada Tikus Jantan Tiara Fortuna A.R; Muhammad Yunus; Astriani Natalia Br Ginting
Jurnal Rumpun Ilmu Kesehatan Vol. 5 No. 3 (2025): November: Jurnal Rumpun Ilmu Kesehatan
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jrik.v5i3.5518

Abstract

Burn injuries are a significant health problem because they damage the skin’s protective barrier, increase the risk of infection, and may cause severe complications if not treated properly. The healing process is complex and involves several cellular events, in which fibroblasts play a key role by producing collagen and forming granulation tissue. Recently, there has been growing interest in natural, herbal-based therapies for wound care. Tamarind leaves (Tamarindus indica) were chosen in this study because they contain flavonoids, polyphenols, tannins, and saponins, all of which have anti-inflammatory, antioxidant, and tissue-regenerating properties. The aim was to evaluate the effectiveness of ethanol extract gel of tamarind leaves at concentrations of 2.5%, 5%, and 10% in promoting fibroblast proliferation and healing of burn wounds in male rats (Rattus norvegicus). An experimental randomized design was used with six groups: normal control, neative control, positive control, and three treatment groups. Clinical observation and histopathological analysis showed that the extract gel accelerated wound closure significantly compared to the negative control. Fibroblast proliferation was higher in all treatment groups, with the 10% extract giving the best result, similar to Bioplacenton. These findings highlight tamarind leaves’ potential as a safe and affordable alternative for burn wound therapy.
Formulasi dan Uji Aktivitas Antibakteri Gel Minyak Atsiri Rimpang Lengkuas Merah (Alpinia purpurata K. Schum) terhadap Propionibacterium acnes Astriani Natalia Br Ginting; Vera Estefania Kaban; Roy Indrianto Bangar; Daimah W. S. Harahap
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 1 (2025): Februari 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i1.4844

Abstract

Acne is a common dermatological condition caused by the bacterial infection of Propionibacterium acnes, leading to skin inflammation. Red galangal (Alpinia purpurata K. Schum) is known to exhibit antibacterial activity due to its essential oil content, flavonoids, and alkaloids. This study aims to formulate and evaluate the antibacterial activity of a gel preparation based on red galangal rhizome essential oil against Propionibacterium acnes. The research follows a laboratory experimental design, including the extraction of red galangal rhizome essential oil via maceration, formulation of the gel, and evaluation of its physical properties, such as pH, homogeneity, spreadability, and antibacterial activity using the disc diffusion method. The results demonstrated that the gel formulation met the required physicochemical standards, with a pH ranging from 6.4 to 6.8, good homogeneity, and an optimal spreadability of 5–7 cm. The antibacterial test revealed a significant inhibitory effect against Propionibacterium acnes, with an inhibition zone of up to 11.24 mm at a 15% concentration. These findings suggest that red galangal rhizome essential oil possesses strong antibacterial potential, making it a promising candidate for natural topical acne treatment. In conclusion, the red galangal essential oil gel exhibits favorable antibacterial activity against Propionibacterium acnes and has potential as an alternative acne treatment. Further studies are necessary to enhance the stability and efficacy of the formulation for optimal clinical applications.
Efek Pemberian Fraksi Etil Asetat Ekstrak Etanol Kulit Buah Jeruk Bali (Citrus Maxima Merr) terhadap Kadar Glukosa Darah Tikus Hiperglikemia Desita, Maya; Roy Indrianto Bangar Siagian; Astriani Natalia Br Ginting
JOURNAL SAINS STUDENT RESEARCH Vol. 3 No. 6 (2025): Jurnal Sains Student Research (JSSR) Desember
Publisher : CV. KAMPUS AKADEMIK PUBLISING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61722/jssr.v3i6.7120

Abstract

Diabetes Mellitus (DM) is a metabolic disorder characterized by elevated blood glucose levels (hyperglycemia). Herbal medicine is often used as an alternative treatment, and pomelo peel (Citrus maximaMerr) is believed to have potential as an antihyperglycemic agent due to its content of bioactive compounds such as flavonoids and vitamin C. This study aimed to examine the antihyperglycemic effect of the ethyl acetate fraction of the ethanol extract of pomelo peel (Citrus maxima Merr) in alloxan-induced Wistar rats. Hyperglycemic rats were divided into 6 groups (Normal Control, Negative Control, Positive Control/Metformin, and Fraction Doses of 125, 250, 500 mg/kgBW). The treatment was administered for 14 days. The results showed that the pomelo peel ethyl acetate fraction significantly reduced the blood glucose levels of the hyperglycemic rats, with the effect becoming clearly visible by Day 9. This reduction effect was dose-dependent, where the 500 mg/kgBW dose provided the most optimal antihyperglycemic effect, closely approaching the effect of Metformin and the normal group. The ethyl acetate fraction ofpomelo peelis effective in lowering the blood glucose levels of hyperglycemic rats. This activity is strongly suspected to originate from the content of active compounds such as flavonoids, saponins, and alkaloids.
Uji Aktivitas Anti Diabetes Ekstrak Umbi Bawang Dayak (Eleutherine Bulbosa) pada Tikus Putih (Rattus Noverginus ) yang Diinduksi Aloksan Tiara Salsabila; Astriani Natalia Br Ginting; Asyrun Alkhairi Lubis
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5142

Abstract

This study aims to examine the antidiabetic activity of ethanol extract of Dayak onion (Eleutherine bulbosa) bulbs in white rats (Rattus norvegicus) induced by alloxan. Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or both. This condition can lead to various serious complications, such as kidney damage, cardiovascular disorders, neuropathy, and impaired wound healing. As the prevalence of diabetes increases globally, the search for safer and more affordable alternative therapies has become a crucial need, especially in developing countries. In recent years, the use of medicinal plants as alternative therapies for diabetes mellitus has received increasing research. Dayak onion is a herbal plant that has long been traditionally used by the people of Kalimantan to treat various diseases, including diabetes. The content of secondary metabolites in Dayak onion bulbs, such as flavonoids, alkaloids, tannins, saponins, and glycosides, is believed to act as a hypoglycemic agent. Flavonoids, for example, are known to have antioxidant activity that can protect pancreatic beta cells from oxidative damage, while saponins can inhibit glucose absorption in the intestine. This study used an experimental method with a post-test only control group design approach. Rats were induced with a certain dose of alloxan to create hyperglycemic conditions, then divided into several groups, including a negative control group, a positive control group (given standard drugs such as metformin), and a treatment group that received ethanol extract of Dayak onion bulbs at varying doses. Blood glucose levels were measured on days 0, 7, and 14 after treatment. It is hoped that the results of this study can provide strong scientific data regarding the potential of Dayak onion extract as an effective and relatively safe antidiabetic agent, as well as become the basis for the development of phytopharmaceutical drugs based on local Indonesian plants.
Co-Authors Asyrun Alkhairi Lubis Daimah W. S. Harahap Desita, Maya Hikmad Elsi Enoni Harefa Muhammad Yunus Nerly Juli Pranita Simanjuntak Rena Meutia Roy Indrianto Bangar Roy Indrianto Bangar Siagian Sosa Ester Kristiani Lase Tiara Fortuna A.R Tiara Salsabila Vera Estefania Kaban