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All Journal Jurnal Sains Student Research Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Astriani Natalia Br Ginting
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Efek Pemberian Fraksi Etil Asetat Ekstrak Etanol Kulit Buah Jeruk Bali (Citrus Maxima Merr) terhadap Kadar Glukosa Darah Tikus Hiperglikemia Desita, Maya; Roy Indrianto Bangar Siagian; Astriani Natalia Br Ginting
JOURNAL SAINS STUDENT RESEARCH Vol. 3 No. 6 (2025): Jurnal Sains Student Research (JSSR) Desember
Publisher : CV. KAMPUS AKADEMIK PUBLISING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61722/jssr.v3i6.7120

Abstract

Diabetes Mellitus (DM) is a metabolic disorder characterized by elevated blood glucose levels (hyperglycemia). Herbal medicine is often used as an alternative treatment, and pomelo peel (Citrus maximaMerr) is believed to have potential as an antihyperglycemic agent due to its content of bioactive compounds such as flavonoids and vitamin C. This study aimed to examine the antihyperglycemic effect of the ethyl acetate fraction of the ethanol extract of pomelo peel (Citrus maxima Merr) in alloxan-induced Wistar rats. Hyperglycemic rats were divided into 6 groups (Normal Control, Negative Control, Positive Control/Metformin, and Fraction Doses of 125, 250, 500 mg/kgBW). The treatment was administered for 14 days. The results showed that the pomelo peel ethyl acetate fraction significantly reduced the blood glucose levels of the hyperglycemic rats, with the effect becoming clearly visible by Day 9. This reduction effect was dose-dependent, where the 500 mg/kgBW dose provided the most optimal antihyperglycemic effect, closely approaching the effect of Metformin and the normal group. The ethyl acetate fraction ofpomelo peelis effective in lowering the blood glucose levels of hyperglycemic rats. This activity is strongly suspected to originate from the content of active compounds such as flavonoids, saponins, and alkaloids.
Aktivitas Nano Spray Gel Ekstrak Kulit Nanas (Ananas comosus L.) terhadap Pertumbuhan Bakteri Staphylococcus epidermidis pada Ulkus Diabetes Melitus Secara In Vitro Jesiska Muaratan; Astriani Natalia Br Ginting; Rena Meutia; Nerly Juli Pranita Simanjuntak
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 3 (2025): Juli : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i3.659

Abstract

Diabetic ulcers are complications of diabetes mellitus often associated with bacterial infections like Staphylococcus epidermidis. Pineapple peel is rich in secondary metabolites including flavonoids with potential antibacterial effects. This study aimed to assesss the antibacterial activity of nano spray gel made with pineapple peel extract against Staphylococcus epidermidis through in vitro testing. This research employed a laboratory experimental design using nano spray gel formulations at varying concentrations of 25%, 50%, and 75% of pineapple peel extract. Flavonoids, alkaloids, tannins, and saponins are confirmed by phytochemical analysis. Only the formulation with 75% demonstrated antibacterial activity effect, with an average inhibition zone of 8.61 mm (medium category). 25% and 50% formulations show no inhibition. Pure extract showed a 15.42 mm zone (strong), while the positive control (clindamycin) produced 29.69 mm (very strong) inhibition zone. PSA results indicated particle size averaged 1480 nm, exceeding the nanoemulsion standard (<500 nm). Nano spray gel with 75% pineapple peel extract demonstrated antibacterial activity against S. epidermidis, although the particle size did not meet nanoemulsion criteria.
Uji Aktivitas Anti Diabetes Ekstrak Umbi Bawang Dayak (Eleutherine Bulbosa) pada Tikus Putih (Rattus Noverginus ) yang Diinduksi Aloksan Tiara Salsabila; Astriani Natalia Br Ginting; Asyrun Alkhairi Lubis
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 4 No. 1 (2025): Januari : Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v4i1.5142

Abstract

This study aims to examine the antidiabetic activity of ethanol extract of Dayak onion (Eleutherine bulbosa) bulbs in white rats (Rattus norvegicus) induced by alloxan. Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or both. This condition can lead to various serious complications, such as kidney damage, cardiovascular disorders, neuropathy, and impaired wound healing. As the prevalence of diabetes increases globally, the search for safer and more affordable alternative therapies has become a crucial need, especially in developing countries. In recent years, the use of medicinal plants as alternative therapies for diabetes mellitus has received increasing research. Dayak onion is a herbal plant that has long been traditionally used by the people of Kalimantan to treat various diseases, including diabetes. The content of secondary metabolites in Dayak onion bulbs, such as flavonoids, alkaloids, tannins, saponins, and glycosides, is believed to act as a hypoglycemic agent. Flavonoids, for example, are known to have antioxidant activity that can protect pancreatic beta cells from oxidative damage, while saponins can inhibit glucose absorption in the intestine. This study used an experimental method with a post-test only control group design approach. Rats were induced with a certain dose of alloxan to create hyperglycemic conditions, then divided into several groups, including a negative control group, a positive control group (given standard drugs such as metformin), and a treatment group that received ethanol extract of Dayak onion bulbs at varying doses. Blood glucose levels were measured on days 0, 7, and 14 after treatment. It is hoped that the results of this study can provide strong scientific data regarding the potential of Dayak onion extract as an effective and relatively safe antidiabetic agent, as well as become the basis for the development of phytopharmaceutical drugs based on local Indonesian plants.
Co-Authors Asyrun Alkhairi Lubis Desita, Maya Jesiska Muaratan Nerly Juli Pranita Simanjuntak Rena Meutia Roy Indrianto Bangar S Tiara Salsabila