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All Journal Jurnal Impresi Indonesia Journal of Social Research
Nugrohoaji Dharmawan
Universitas Sebelas Maret, Indonesia
Religion Humanities Computer Science & IT Economics, Econometrics & Finance Education Law, Crime, Criminology & Criminal Justice Social Sciences

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Topical Polypeptide Gel in Diabetic Ulcers: Clinical Insights Into a New Adjunctive Treatment Modality Stella Gracia Octarica; Suci Widhiati; Endra Yustin Ellistasari; Nugrohoaji Dharmawan; Indah Julianto
Journal of Social Research Vol. 4 No. 10 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i9.2794

Abstract

Diabetic ulcers are a common and challenging complication of diabetes, contributing to morbidity, infection, and a high risk of amputation. Innovative adjuncts, such as topical polypeptide gel, which contains amino acids to support tissue regeneration, are proposed to accelerate wound healing; however, supporting clinical data are limited. A quasi-experimental analysis was conducted in 11 patients. Each received a daily topical 7% polypeptide gel in addition to standard care. Ulcer area was measured at baseline (day 0) and after 14 days using digital documentation analysis using ImageJ. The primary outcome was the percentage reduction in ulcer size. Patients were analysed for associations between percentage of improvement with age, gender, diabetes type, and ulcer site. Eleven patients with diabetic ulcers completed the 14-day treatment protocol. The cohort comprised 54.5% females with a mean age of 54.1 ± 7.3 years and predominantly insulin-dependent diabetes (72.7%). Baseline ulcer area averaged 982.1 ± 1315.1 mm², reducing to 184.0 ± 297.7 mm² by day 14, representing an 86.2 ± 6.7% mean area reduction. All patients achieved ?76% healing, with 45.5% achieving ?90% area reduction and 9.1% achieving complete healing. The Wilcoxon signed-rank test demonstrated statistically significant ulcer area reduction (Z = -2.934, p = 0.003). No significant associations were found between healing percentage and patient demographics, diabetes type, ulcer location, or comorbidity burden (all p > 0.05). No treatment-related adverse events were reported during the study period. Topical polypeptide gel demonstrated rapid wound surface area reduction in the majority of the subjects over 14 days, independent of patient age, gender, diabetes type, or ulcer location. These findings suggest its promise as an adjunctive early-phase therapy for diabetic ulcers.
The Clinical Relevance of Serum Interleukin-21 in Grading Acne Vulgaris Ayu Kusuma Dewi; Muhammad Eko Irawanto; Arie Kusumawardani; Nugrohoaji Dharmawan; Nurrachmat Mulianto
Journal of Social Research Vol. 4 No. 11 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i10.2795

Abstract

Acne vulgaris (AV) is an inflammatory skin disorder with multifactorial pathogenesis involving genetics, hormones, and immune dysregulation. Interleukin-21 (IL-21), a pleiotropic cytokine mainly secreted by T follicular helper and Th17 cells, has been implicated in various inflammatory skin diseases. However, its role in AV remains unclear. This cross-sectional study included 46 patients with AV, classified into mild (n=19), moderate (n=16), and severe (n=11) groups. Serum IL-21 levels were measured using an enzyme-linked immunosorbent assay (ELISA). Baseline characteristics were compared across groups, and interobserver reliability of AV severity grading was evaluated using Cohen’s kappa test. One-way ANOVA was applied to assess differences in IL-21 levels among severity groups, with a significance level set at p<0.05. The mean serum IL-21 level was highest in the severe AV group (303.53 pg/mL), followed by the moderate (223.7 pg/mL) and mild (213.2 pg/mL) groups. Although there was a trend toward increasing IL-21 levels with higher AV severity, statistical analysis revealed no significant difference among the three groups (p=0.130). Serum IL-21 levels were elevated in AV patients compared with previously reported healthy controls but did not differ significantly across severity levels. These findings suggest that IL-21 may play a role in the pathophysiology of AV, though it is not a reliable marker of clinical severity. Further case-control and tissue-based studies are needed to clarify its role.
Cluster Differentiation 133 Expression in Patients With Basal Cell Carcinoma: an Immunohistochemical Review Rahmat Firdaus Dwi Utama; Nugrohoaji Dharmawan; Ammarilis Murastami; Nurrachmat Mulianto; Novan Adi Setyawan
Journal of Social Research Vol. 4 No. 10 (2025): Journal of Social Research
Publisher : International Journal Labs

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55324/josr.v4i9.2802

Abstract

Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer in humans, developing on skin exposed to ultraviolet light and rarely metastasizing. Cancer stem cell markers such as CD133 have been extensively studied in various malignancies, but their expression in BCC remains controversial and has not been widely studied in Indonesia. Determine the difference in CD133 expression between BCC patients and normal skin. Analytical observational study with a case control design was conducted at Dr. Moewardi General Hospital in Surakarta from April to July 2025. The sample included 13 BCC tissues and 13 normal skin controls taken by consecutive sampling from paraffin blocks from 2021-2024. CD133 immunohistochemical staining was performed with Allred scoring by a single pathologist on at least four random fields of view. Descriptive analysis presented demographic characteristics and Allred scores, while the Chi square test was used to compare CD133 expression between groups with significance at p < 0.05. The mean CD133 Allred score was 7.15 ± 0.56 in KSB tissue and 7.31 ± 0.48 in normal skin. Strongly positive CD133 expression was found in 12/13 BCC patients and 13/13 normal skin. Chi square analysis showed no significant difference in CD133 expression between the BCC and normal skin groups (p=0.308). CD133 expression based on the Allred score did not differ significantly between BCC tissue and normal skin, indicating that CD133 is not useful as a single marker for the diagnosis or prognosis of KSB
Hubungan Karakteristik Klinis dengan Gambaran Histopatologi Pasien Karsinoma Sel Basal di RSUD Dr. Moewardi Surakarta Sugih Primas Adjie; Prasetyadi Mawardi; Nugrohoaji Dharmawan; Indah Julianto
Jurnal Impresi Indonesia Vol. 4 No. 10 (2025): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v4i10.7060

Abstract

Basal cell carcinoma (BCC) is the most common non-melanoma skin cancer, with varying clinical and histopathological manifestations. The infiltrative nature of BCC affects tumor aggressiveness and its prognosis. In Indonesia, data regarding the relationship between clinical characteristics and histopathological features of BCC are still limited. This study aims to analyze the relationship between clinical characteristics and the infiltrative nature in BCC patients at Dr. Moewardi General Hospital, Surakarta. A retrospective cross-sectional study used medical records and paraffin blocks of BCC patients diagnosed from January 2021 to February 2025. The evaluated characteristics included age, sex, anatomical location, lesion size, and histopathological subtypes. Histopathological features were analyzed based on infiltrative and non-infiltrative tumor characteristics. Of the 29 patients analyzed, the majority were female (55.2%) with a median age of 57 years. Most lesions were ?2 cm² (82.8%) and located on the middle face (75.9%). The dominant histopathological subtypes were nodulo-ulcerative (41.4%) and nodular (34.4%). Only 48.3% of cases were infiltrative. No significant relationship was found between clinical characteristics and the infiltrative nature of the tumor, emphasizing the importance of histopathological evaluation in determining tumor aggressiveness. These findings are essential for the development of diagnostic and therapeutic strategies for BCC in Indonesia.
Co-Authors Ammarilis Murastami Arie Kusumawardani Ayu Kusuma Dewi Endra Yustin Ellistasari Indah Julianto Muhammad Eko Irawanto Novan Adi Setyawan Nurrachmat Mulianto Prasetyadi Mawardi Rahmat Firdaus Dwi Utama Stella Gracia Octarica Suci Widhiati Sugih Primas Adjie