Article Per Year (5 Year)
p-Index From 2021 - 2026
0.23
P-Index
This Author published in this journals
All Journal JFIOnline Indonesian Journal of Science and Pharmacy
Milala, Alasen Sembiring
Fakultas Farmasi Universitas Surabaya
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Karakteristik Fisik dan Displacement Value Supositoria Neomisin Sulfat berbasis PEG Boehe, Andrew Pierce; Milala, Alasen Sembiring; Pradana, Aditya Trias
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 3 (2013)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6516.26 KB)

Abstract

Physical characteristic and the Displacement Value of neomycin sulfate in suppository with various composition of PEG 400-4000 as it carrier has been studied. Displacement Value has been determined to adjust the weight of suppositories that varies due to the density difference among drug substance and its carriers. The method used in the determination of Displacement Value is the Moody method. Beside the displacement value, we have also evaluated the physical characteristic of suppository that has been produced, such as weight uniformity, hardness, macro and micro melting point and liquefaction ability. The results shows that all measurements meet the requirements and the Displacement Value of Neomycin sulfate obtained from Moody method, was 0.96.Keywords : Suppository, Displacement Value, Neomycin sulfate.
Karakteristik Fisik dan Displacement Value Supositoria Neomisin Sulfat berbasis PEG Milala, Alasen Sembiring; Pradana, Aditya Trias; Boehe, Andrew Pierce
Jurnal Farmasi Indonesia Vol 6, No 3 (2013)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6516.26 KB) | DOI: 10.35617/jfi.v6i3.158

Abstract

Physical characteristic and the Displacement Value of neomycin sulfate in suppository with various composition of PEG 400-4000 as it carrier has been studied. Displacement Value has been determined to adjust the weight of suppositories that varies due to the density difference among drug substance and its carriers. The method used in the determination of Displacement Value is the Moody method. Beside the displacement value, we have also evaluated the physical characteristic of suppository that has been produced, such as weight uniformity, hardness, macro and micro melting point and liquefaction ability. The results shows that all measurements meet the requirements and the Displacement Value of Neomycin sulfate obtained from Moody method, was 0.96.Keywords : Suppository, Displacement Value, Neomycin sulfate.
Critical Evaluation of Lecithin-Tween 80 Parenteral Emulsion: Challenges in Maintaining Droplet Size Post-Sterilisation Milala, Alasen Sembiring; Aryani, Ni Luh Dewi; Purnomo, Ika Angelina
Indonesian Journal of Science and Pharmacy Vol. 3 No. 3 (2026): Indonesian Journal of Science and Pharmacy
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/ijsp.v3i3.132

Abstract

Parenteral emulsions are essential for patients with gastrointestinal disorders. Lecithin benefits liver function, but formulating sterilisation-stable emulsions while maintaining safe droplet size remains challenging. The objective of this study was to evaluate the physical stability of a lecithin-Tween 80 combination parenteral emulsion following sterilisation, focusing on droplet size as a critical parameter. Formulation contained lecithin (5%), Tween 80 (20%), isopropyl myristate (9%), propylene glycol (1%), nipagin (0.18%), nipasol (0.02%), and cassava starch (2.5%) in Water for Injection. Emulsion was prepared mechanically using a multimix mixer at 1500 rpm. Three bottles were sterilised by autoclaving (115°C, 30 minutes); one bottle remained unsterilised as control. Seven-day evaluation assessed organoleptic properties, pH, viscosity, droplet size, creaming, and sterility. Statistical analysis used T-test and one-way ANOVA. Sterilisation significantly increased droplet size (p<0.05), from 5.90±0.45 μm to 8.48±0.62 μm. White precipitate (cassava starch) formed in all preparations from day 2. pH remained stable (5.00-5.42). Viscosity decreased by 47% (111.04 cP to 58.86 cP). Sterility testing revealed microbial growth. The lecithin-Tween 80 parenteral emulsion containing cassava starch requires further optimisation. Key concerns include selecting a more suitable stabiliser, adjusting pH, and sterilising raw materials prior to formulation. This study offers valuable insights for developing future parenteral emulsion preparations.
Co-Authors Aditya Trias Pradana Aryani, Ni Luh Dewi Boehe, Andrew Pierce Boehe, Andrew Pierce Purnomo, Ika Angelina