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Karakteristik Fisik dan Displacement Value Supositoria Neomisin Sulfat berbasis PEG Boehe, Andrew Pierce; Milala, Alasen Sembiring; Pradana, Aditya Trias
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 6, No 3 (2013)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (6516.26 KB)

Physical characteristic and the Displacement Value of neomycin sulfate in suppository with various composition of PEG 400-4000 as it carrier has been studied. Displacement Value has been determined to adjust the weight of suppositories that varies due to the density difference among drug substance and its carriers. The method used in the determination of Displacement Value is the Moody method. Beside the displacement value, we have also evaluated the physical characteristic of suppository that has been produced, such as weight uniformity, hardness, macro and micro melting point and liquefaction ability. The results shows that all measurements meet the requirements and the Displacement Value of Neomycin sulfate obtained from Moody method, was 0.96.Keywords : Suppository, Displacement Value, Neomycin sulfate.

Karakteristik Fisik dan Displacement Value Supositoria Neomisin Sulfat berbasis PEG Milala, Alasen Sembiring; Pradana, Aditya Trias; Boehe, Andrew Pierce
Jurnal Farmasi Indonesia Vol 6, No 3 (2013)
Publisher : Jurnal Farmasi Indonesia

Physical characteristic and the Displacement Value of neomycin sulfate in suppository with various composition of PEG 400-4000 as it carrier has been studied. Displacement Value has been determined to adjust the weight of suppositories that varies due to the density difference among drug substance and its carriers. The method used in the determination of Displacement Value is the Moody method. Beside the displacement value, we have also evaluated the physical characteristic of suppository that has been produced, such as weight uniformity, hardness, macro and micro melting point and liquefaction ability. The results shows that all measurements meet the requirements and the Displacement Value of Neomycin sulfate obtained from Moody method, was 0.96.Keywords : Suppository, Displacement Value, Neomycin sulfate.

The effect of spray-drying temperature on Centella asiatica extract-Î² cyclodextrin-maltodextrin nanoparticle characteristics and stability Aditya Trias Pradana; Roisah Nawatila; Fawandi Fuad Alkindi; Ni Putu Resa Darmayani; Eka Desi Susanti
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Centella asiaticaÂ extract has low solubility in water. Material modification needs to be conducted to increase the dissolution rate of Centella asiaticaÂ extract. The particle size reduction to nano-size was carried out to increase surface contact with aqueous media. High surface contact was expected to increase the solubility and absorption rate. Nanoparticles were prepared with 34% maltodextrin and 6% Î²-cyclodextrin as a stabilizer and dried by a spray-drying method. High temperature in the spray drying process can affect the physical and chemical characteristics of the nanoparticles, so the inlet temperature in this study was observed as parameter variations, on 140oC, 150oC, and 160oC. The formed nanoparticles then being tested on several parameters, including physical appearance, moisture content, particle size, shape, and morphology. The chemical stability of the active ingredients during the drying process was assessed from the pH value changes and the content of quercetin as an antioxidant post drying process, compared to the initial content. The test results show that the nanoparticles have been formed. The inlet temperature of 160oC produced the most physically optimum spherical nanoparticles, with a particle size of 191.533 Â± 18.791 nm and relatively homogeneous with a polydispersity index (PDI) value of 0.113 Â± 0.057. However, temperatures that are too high indicate poor chemical stability. The poor chemical stability can be seen from the quercetin content that decreased significantly after the drying process, until the remaining 53.87 Â± 0.55% and 49.52 Â± 0.97% for temperatures of 140oC and 160oC, respectively. These results indicate that the combination of Î²-cyclodextrin and maltodextrin can not encapsulate and maintain the stability of the active ingredients during the spray drying process. A significant reduction of inlet temperature is needed to get dry nanoparticles with the most optimum physical mixture and chemical stability.

Hubungan Antar Faktor Penyebab Human Error Terhadap Jumlah Penyimpangan Produk Blister Di PT. XXX Nurliya Irfiani; Aditya Trias Pradana; Agnes Nuniek Winantari
MPI (Media Pharmaceutica Indonesiana) Vol. 2 No. 2 (2018): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Human error is the main cause of blister product quality deviation at PT. XXX, which lead by personnel factor and work method. The research intends to analyze the relationship between personnel qualification level (blister production team), number of blister product and production length (Z blister machine), with blister product deviation at PT. XXX (2015-2017). The research was a descriptive-observational study (retrospective) by linier regression analysis using 2 variables and multi variable. The t-test analysis result between personnel qualification level and blister product deviation, p=0.041 (p<0.05) showed a significant relationship between those variables. The t-test analysis result between number of blister product and blister product deviation, p=0.164 (p>0.05) showed that there is no significant relationship between those variables. The result of t-test between production length (Z blister machine) and blister product deviation, p=0.542 (p>0.05) showed that there is no significant relationship between those variables. The F-test analysis result showed a significant relationship between personnel qualification level (blister production team), number of blister product and production length (Z blister machine) with blister product deviation (p=0,000; p<0.05).

Pengembangan Granul Herbal Pada Tanaman Kumis Kucing, Temulawak, dan Pegagan dengan Pengisi Maltodextrine dan Spray Dried Lactose Roisah Nawatila; Diva Amadea Nabilla; Fransiska Levina Oktaviani; Rista Noer Efendi; Ade Ayu Kintan Anjarsari; Chintya Dewi Tanuwijaya; Rahma Anida Putri; Aditya Trias Pradana
MPI (Media Pharmaceutica Indonesiana) Vol. 3 No. 1 (2020): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v3i1.2790

Pemanfaatan produk herbal di Indonesia semakin berkembang sejak tahun 2008. Daun kumis kucing (Orthosiphon stamineus), rimpang temulawak (Curcuma xanthorrhiza), dan herba pegagan (Centella asiatica) memiliki khasiat dalam mengatasi hipertensi ringan, namun masih memiliki rasa yang kurang enak. Oleh karena itu, pada penelitian ini dilakukan pengembangan produk herbal yang inovatif berupa granul yang dibuat dengan metode granulasi kering dengan pengisi Maltodextrine dan Spray Dried Lactose (SDL). Pada formula 1 menggunakan Maltodextrine, formula 2 menggunakan SDL, dan formula 3 menggunakan kombinasi dari kedua pengisi (1:1 w/w). Tujuan penelitian ini adalah untuk menentukan pengaruh jenis pengisi terhadap mutu fisik granul herbal. Data mutu fisik dianalisis statistik menggunakan metode oneway ANOVA (α = 0,05). Hasil penelitian menunjukkan bahwa pengisi maltodextrine memberikan mutu fisik (terutama pada sifat alir granul) yang lebih optimal apabila dibandingkan dengan menggunakan pengisi spray dried lactose atau kombinasi keduanya.

Formulasi Granul Minuman Fungsional Kombinasi Ekstrak Etanol Daun Jambu Biji (Psidium guajava) dan Ekstrak Etanol Biji Klabet (Trigonella foenum-graecum) Arya Eka Wardhana; Karina Citra Rani; Aditya Trias Pradana; Nikmatul Ikhrom Eka Jayani
MPI (Media Pharmaceutica Indonesiana) Vol. 3 No. 4 (2021): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v3i4.4771

Minuman fungsional diharapkan dapat memberikan manfaat kesehatan diantaranya meningkatkan imunitas, membantu pencernaan, menurunkan kolesterol, mengandung serat tinggi, dan dapat menurunkan kadar gula. Daun jambu biji dan biji klabet berpotensi untuk dikembangkan menjadi minuman fungsinal terutama karena aktivitas antioksidannya yang tinggi. Tujuan penelitian ini adalah untuk mendapatkan formula terbaik granul minuman fungsional kombinasi ekstrak etanol daun jambu biji dengan ekstrak etanol biji klabet yang memenuhi spesifikasi dan diterima oleh panelis pada pegujian hedonik. Granul minuman fungsional dibuat dalam empat formula dengan berbagai rasio ekstrak etanol daun jambu biji dibanding ekstrak etanol biji klabet, yaitu: Formula I (3%:0%), Formula II (3%:1%), Formula III (3%:2%), dan Formula IV (3%:3%). Granul diformulasi dengan metode granulasi basah, kemudian dievaluasi karakteristik fisiknya. Hasil uji karakteristik fisik granul menunjukkan rerata kandungan lembab 1,35-1,81%; fines 2,36-6,26%; kecepatan alir 6,99-8,92 g/detik; sudut istirahat 31,60-34,70°; indeks kompresibilitas 17,38-20,42%; rasio Hausner 1,21-1,25. Uji hedonik menunjukkan rerata skor parameter warna (3,32-3,76), bau (3,32-4,00), dan rasa (3,60-4,32). Formula terbaik yang memenuhi spesifikasi dan paling diterima oleh panelis pada pegujian hedonik adalah formula IV.

FORMULATION AND STABILITY STUDY OF DETAM I SOYBEAN VARIETY (GLYCINE MAX (L.) MERR.) EFFERVESCENT GRANULES WITH DIFFERENT TYPE OF EFFERVESCENT AGENTS Aditya Trias Pradana; Christentia Steffany; Rika Yulia
Acta Pharmaceutica Indonesia Vol. 46 No. 2 (2021)
Publisher : School of Pharmacy Institut Teknologi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5614/api.v46i2.15751

The research was conducted to analyze the effect of different types and concentrations of the acid source on the physical characteristics and chemical stability of black soybean (Glycine max (L.) Merr.) Detam I variety effervescent granules. Effervescent granules were made in three different acid sources, which are 15% citric acid for formula I, a mixture of 5% citric acid and 10% tartaric acid for formula II and a mixture of 8% citric acid and 16% tartaric acid for formula III, respectively. The granules’ physical characteristics were obtained by particle size distribution, specific density, bulk density, moisture content, flow time, angle of repose, and effervescent time. Total phenolic content was evaluated for 28 days and the samples were collected at 0, 1, 4, 7, 14, 21, and 28 days. The sample was then measured using a visible spectrophotometric method at 505.5 nm wavelength. The results showed that granule effervescent with formula III was selected as the best formula in all parameters measured, except on the particle size distribution result. In addition, total phenolic in the formula I was the highest content with a better stability profile, compared to formula II and III. It showed that the formula with a combination of 8% citric acid: 16% tartaric acid is the most optimum formula physically, even for further research, adsorbent use or binder ratio in the formula, and moisture resistant of the primary packaging must also be considered.

KARAKTERISTIK FISIK MIKROPARTIKEL KUERSETIN DENGAN KOMBINASI KITOSAN-NATRIUM TRIPOLIFOSFAT MENGGUNAKAN METODE ORIFICE IONIC GELATION Aditya Trias Pradana; Roisah Nawatila; Muhammad Rifani Rachman
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 7 No 1 (2022): JIIS
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Antioxidants are compounds to resist free radicals. The natural antioxidant group that is currently being developed is the flavonoid group, one of which is quercetin. Quercetin has a low solubility, so it can be increased by reducing the particle size. This study aims to determine the differences that are influenced by the combination of chitosan polymer and sodium tripolyphosphate as matrix forming quercetin microparticles on the physical characteristics of the results made using the orifice ionic gelation method. The resulting preparation showed a particle size of 1326.33 nm; 3497.33 nm; and 6000 nm at various concentrations of 0.2% chitosan and 0.1%; 0.2%; and 0.3% sodium tripolyphosphate, respectively. The Fourier Transform Infrared (FTIR) results showed that there was no change in the marker group on quercetin and an ionic bond was formed between chitosan and sodium tripolyphosphate. The X-ray Diffractometer (XRD) results showed that the crystalline structure of quercetin changed to become more amorphous. Although the Scanning Electron Microscope (SEM) results, it is seen that the quercetin microparticles produced are needle-shaped, especially when the concentration of sodium tripolyphosphate is increased. Based on the results of these physical characteristics, it can be proven that the microparticle was formed at various concentrations of the polymer concentration combination with the best characteristics are on 0.2% chitosan and 0.1% sodium tripolyphosphate concentration.

Kajian Pembentukan Dispersi Padat Atenolol Menggunakan Metode Freeze Drying Maulita, Arina Swastika; Winantari, Agnes Nuniek; Rani, Karina Citra; Pradana, Aditya Trias; Kesuma, Dini
MPI (Media Pharmaceutica Indonesiana) Vol. 7 No. 1 (2025): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v7i1.7334

Atenolol merupakan obat golongan β1-adrenoblocker selektif yang digunakan untuk mengobati kondisi kardiovaskular seperti hipertensi dan angina pektoris. Namun, atenolol memiliki kelarutan dan permeabilitas yang rendah hal ini dapat membatasi bioavailabilitas oralnya. Salah satu metode yang efektif untuk meningkatkan kelarutan dan laju disolusi obat dengan kelarutan rendah adalah melalui pembentukan dispersi padat. Dispersi padat melibatkan pembawa obat dalam matriks yang bersifat inert dalam keadaan padat, yang dapat meningkatkan kelarutan dan stabilitas obat. Metode freeze drying (liofilisasi) digunakan dalam pembuatan dispersi padat atenolol untuk menghindari dekomposisi termal dan menghasilkan dispersi molekuler yang homogen. Karakterisasi dispersi padat yang dihasilkan meliputi analisis morfologi, identifikasi gugus fungsi, sifat kristalinitas, analisis termal, ukuran partikel, distribusi ukuran partikel, dan potensi zeta. Pada berbagai penelitian sebelumnya menunjukkan bahwa dispersi padat dapat meningkatkan kelarutan dan laju disolusi atenolol secara signifikan. Atenolol is a selective β1-adrenoblocker drug used to treat cardiovascular conditions such as hypertension and angina pectoris. However, atenolol has low solubility and permeability, which can limit its oral bioavailability. One effective method to increase the solubility and dissolution rate of drugs with low solubility is through the formation of solid dispersions. Solid dispersions involve drug carriers in an inert matrix in the solid state, which can increase the solubility and stability of the drug. The freeze drying (lyophilization) method is used in the preparation of atenolol solid dispersions to avoid thermal decomposition and produce homogeneous molecular dispersions. Characterization of the resulting solid dispersions includes morphological analysis, identification of functional groups, crystallinity properties, thermal analysis, particle size, particle size distribution, and zeta potential. Various previous studies have shown that solid dispersions can significantly increase the solubility and dissolution rate of atenolol. Submitted: 05-02-2025, Revised: 10-04-2025, Accepted: 16-05-2025, Published regularly: June 2025

PENGEMBANGAN SENTRA PENGOLAHAN HERBAL PADA KELOMPOK ASUHAN MANDIRI ASMAN TOGA DESA WAGE MELALUI PELATIHAN DAN PENDAMPINGAN PEMBUATAN Setiawan, Finna; Pradana, Aditya Trias; Hadi, Faizal Susilo; Kusyairi, Achmad; Jayani, Nikmatul Ikhrom Eka; Rani, Karina Citra
RESONA : Jurnal Ilmiah Pengabdian Masyarakat Vol 8, No 2 (2024)
Publisher : Lembaga Penerbitan dan Publikasi Ilmiah (LPPI) Universitas Muhammadiyah Palopo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35906/resona.v8i2.2164

Pemberdayaan Asuhan Mandiri (Asman) TOGA, Desa Wage, Kecamatan Taman, Kabupaten Sidoarjo, Jawa Timur dilakukan dalam upaya memanfaatkan potensi dan menyelesaikan permasalahan yang dialami mitra. Program ini dilaksanakan atas kerjasama antara UBAYA, UNITOMO, pemerintah Desa Wage, dan mitra. Pelatihan dan pendampingan khususnya terkait diversifikasi dan pengembangan produk olahan berbasis TOGA dilakukan dengan tujuan meningkatkan pengetahuan dan ketrampilan mitra, serta memotivasi dalma upaya menciptakan berbagai produk olahan berbasis TOGA. Metode yang dilakukan mulai dari analisis situasi, pemaparan materi, diskusi interaktif, praktik pembuatan produk, dan monitoring. Mitra secara aktif berpartisipasi dalam proses diskusi interaktif maupun proses pembuatan produk. Pada kegiatan ini dilakukan pembuatan 2 jenis produk minuman serbuk instan yaitu wedang pokak dna jahe instan. Pada Produk wedang pokak telah dilakukan desain kemasan untuk wedang pokak. Hasil kegiatan ini menunjukkan adanya peningkatan pengetahuan dan ketrampilan kelompok yang terlihat dari dihasilkannya produk wedang pokak yang siap dipasarkan. Diharapkan produk ini akan menjadi salah satu produk unggulan kelompok Asman TOGA, Desa Wage. Abstract. Empowerement of Asuhan Mandiri (Asman) TOGA, Wage Village, Taman Subdistrict,Sidoarjo District, Sidoarjo Regency, East Java was carried out to utilizes potential and solve the problems of this group.This program was conducted by collaboration of UBAYA, UNITOMO Wage Village government, and Asman TOGA. This program was focused to diversification and development of TOGA based products. The aim to improving of knowledge and skills, as well as motivating them to create new products. The methods used includes analysis of situation, sharing knowledge, interactive discussion, and practise to making product. From this activity, we got two produts are wedang pokak and jahe instan. The result of this programme showed an increase of knowledge and skill of this group, this is obtained from the new prodcut that produced which is ready for the market. Hopefully, this product will become one if the superior product from Asman TOGA,Desa Wage,

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