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All Journal Indonesian Journal of Chemical Science Jurnal Pengabdian Masyarakat Tropis Indonesia
Resti Aulia Lestari
Universitas Mataram
Chemistry Physics

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Implementation of Greening, Local Ecotourism, and Drip Irrigation Programs to Increase Environmental Awareness in Durian Village Gilang Cahya; Putri Nurul Khalifah; Amanda Maharani; Resti Aulia Lestari; Ida Ayu Indira Prameswari; Sahrul Gunawan; Ida Apriani; Muhammad Haris Satyawan Rahman; Miftahul Jannah
Jurnal Pengabdian Masyarakat Tropis Indonesia Vol. 2 No. 1 (2026): April
Publisher : Yayasan Siti Widhatul Faeha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.65622/jpmti.v2i1.226

Abstract

Durian Village in Janapria District possesses considerable natural resource potential; however, its management and utilization have not yet been optimized to support sustainable development. Therefore, this program aimed to support sustainable village development through the integration of greening initiatives, ecotourism development, and water conservation education implemented through the Community Empowerment Village Fieldwork Program (CEVFP), locally known as Kuliah Kerja Nyata (KKN), of the University of Mataram. The program applied a participatory approach involving observation, interviews, community socialization, and direct collaboration with residents and village authorities. The activities included planting seedlings and trees in strategic village areas, mapping and initial arrangement of locations with potential to become ecotourism destinations, and providing counseling accompanied by simple demonstrations of drip irrigation technology to promote water-use efficiency. The results showed an increase in community awareness of environmental conservation, growing public participation in maintaining planted vegetation, and emerging interest in developing nature-based tourism potential. In addition, the drip irrigation education provided new insights for farmer groups regarding efficient water use and opportunities to improve agricultural productivity, particularly during the dry season. Overall, the Community Empowerment Village Fieldwork Program (CEVFP/KKN) generated positive ecological and socio-economic impacts on the community. These findings highlight the importance of participatory community-based development models in supporting sustainable village development and emphasize the need for continued assistance, strengthening of village institutions, and collaboration among stakeholders to ensure program sustainability
Molecular Docking Study of Xanthone Targeting the Dihydropteroate Synthase (2VEG) Enzyme in Streptococcus pneumoniae Dia Lestari; Resti Aulia Lestari; Alien Putri Hartiwi; Emmy Yuanita; Diah Miftahul Aini
Indonesian Journal of Chemical Science Vol. 15 No. 2 (2026): Indonesian Journal of Chemical Science
Publisher : Prodi Kimia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/ijcs.v15i2.39291

Abstract

Streptococcus pneumoniae is a pathogenic bacterium causing serious infections, with rising antibiotic resistance highlighting the need for new agents. Dihydropteroate synthase (DHPS) is crucial in bacterial folate biosynthesis and a selective drug target. This study evaluated xanthone derivatives as DHPS inhibitors via molecular docking. Three derivatives namely 1,3,7-trihydroxy-9H-xanthen-9-one (Candidate 1), 1-hydroxy-9-oxo-7-sulfo-9H-xanthene-3-carboxylic acid (Candidate 2), and 9-oxo-1,7-disulfo-9H-xanthene-3-carboxylic acid (Candidate 3), were docked against DHPS (PDB ID: 2VEG) using UCSF Chimera, AutoDock Tools, and AutoDock Vina. Interaction analyses were performed with Discovery Studio and LigPlot+. All candidates bound stably in the DHPS active site; Candidate 2 exhibited the strongest binding (−7.7 kcal/mol) with key hydrogen bonds, while Candidate 3 showed extensive hydrophobic and electrostatic interactions. These results indicate xanthone derivatives, especially Candidate 2, as promising DHPS inhibitors for novel antibacterial development.
Co-Authors Alien Putri Hartiwi Amanda Maharani Dia Lestari Diah Miftahul Aini Emmy Yuanita Gilang Cahya Ida Apriani Ida Ayu Indira Prameswari Miftahul Jannah Muhammad Haris Satyawan Rahman Putri Nurul Khalifah Sahrul Gunawan