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All Journal Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Insan Farmasi Indonesia
Nur Ainah
Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics

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BEYOND THERAPEUTIC BENEFITS: KAJIAN FARMAKOVIGILANS EFEK SAMPING KORTIKOSTEROID DI INDONESIA Senya Puteri Amalia; Farida Istiqamah; Nur Ainah; Desy Ayu Lestari
Jurnal Insan Farmasi Indonesia Vol 9 No 1 (2026): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v9i1.3050

Abstract

Corticosteroids are widely used in clinical practice in Indonesia for the treatment of various diseases. However, prolonged and/or high-dose corticosteroid therapy may lead to serious adverse effects that negatively affect patients’ quality of life. Monitoring of corticosteroid-related adverse drug reactions in Indonesia remains limited, highlighting the need for a pharmacovigilance approach to identify, assess, monitor, and prevent undesirable drug-related events. This review aimed to provide a comprehensive overview of adverse effects associated with corticosteroid use in Indonesia as a basis for safe, effective, and rational therapeutic decision-making. Literature searches were conducted through ScienceDirect, PubMed, Google Scholar, and manual searches using the keywords “pharmacovigilance,” “corticosteroid,” “side effect,” “adverse effect,” and “Indonesia” based on predefined inclusion and exclusion criteria. A total of eight eligible articles were critically analyzed, covering various corticosteroid dosage forms, patient characteristics, and the types and severity of adverse effects. The findings showed that adverse reactions ranged from mild to severe, with increased risk associated with long-term and high-dose corticosteroid use. This review emphasizes the importance of pharmacovigilance in improving healthcare professionals’ awareness and promoting rational corticosteroid use in Indonesia
Analisis In Vitro Daya Hambat Minyak Atsiri Bunga Tanjung (Mimusops elengi L.) terhadap Pertumbuhan Bakteri Streptococcus pneumoniae dan Klebsiella pneumoniae Siti Hawa Ananda; Nur Ainah; Dwi Rizki Febrianti
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 2 (2026): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i2.38655

Abstract

Streptococcus pneumoniae dan Klebsiella pneumoniae merupakan bakteri patogen utama penyebab pneumonia dengan tingkat resistensi antibiotik yang terus meningkat, sehingga diperlukan alternatif antibakteri dari bahan alam. Bunga tanjung (Mimusops elengi L.) diketahui mengandung senyawa bioaktif yang berpotensi sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri minyak atsiri bunga tanjung terhadap S. pneumoniae ATCC 49619 dan K. pneumoniae ATCC 13883 menggunakan metode difusi sumuran dengan konsentrasi 10%, 20%, dan 30%. Ceftriaxone digunakan sebagai kontrol positif dan DMSO 10% sebagai kontrol negatif. Diameter zona hambat diukur setelah inkubasi 24 jam pada suhu 37°C, kemudian dianalisis menggunakan uji One Way ANOVA dan dilanjutkan dengan uji Tukey HSD untuk melihat perbedaan antar perlakuan. Hasil skrining fitokimia menunjukkan adanya senyawa terpenoid dalam minyak atsiri bunga tanjung. Analisis daya hambat antibakteri menunjukkan terbentuknya zona hambat terhadap kedua bakteri uji dengan kategori sedang hingga kuat. Analisis statistik menunjukkan seluruh konsentrasi berbeda signifikan dibandingkan kontrol negatif (p < 0,05). Konsentrasi 20–30% dinyatakan paling efektif karena tidak menunjukkan perbedaan signifikan satu sama lain terhadap kedua bakteri uji.
Co-Authors Desy Ayu Lestari Farida Istiqamah Febrianti, Dwi Rizki Senya Puteri Amalia Siti Hawa Ananda