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Theodorus
Department of Pharmacology, Faculty of Medicine, Universitas Sriwijaya, Palembang, 30114, Indonesia
Health Professions Medicine & Pharmacology Nursing Public Health

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PURPLE SWEET POTATO EXTRACT ATTENUATES GENTAMICIN-INDUCED HEPATOTOXICITY IN WISTAR RATS Evi Lusiana; Theodorus; Khairunnisa Rizqika Amanda Putri
International Archives of Medical Sciences and Public Health Vol. 7 No. 1 (2026): International Archives of Medical Sciences and Public Health
Publisher : Pena Cendekia Insani

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53806/iamsph.v7i1.1474

Abstract

Purple sweet potato extract (Ipomoea batatas L.) has hepatoprotective potential due to its antioxidant properties. This study evaluated the effect of purple sweet potato extract (PSPE) on gentamicin-induced hepatotoxicity in male Wistar rats. Thirty rats were divided into five groups: negative control, positive control, and PSPE-treated groups receiving 50, 100, and 200 mg/kg body weight (BW). Hepatotoxicity was induced using gentamicin for seven days, followed by extract administration for fourteen days. Caspase-3 expression was analyzed using immunohistochemistry, while fibrosis was assessed using Masson’s Trichrome staining and METAVIR scoring. One-way ANOVA showed significant differences in Caspase-3 expression among groups (p ¡ 0.001). PSPE was associated with reduced Caspase-3 expression and attenuated hepatic fibrosis, with the strongest effect observed at 200 mg/kgBW. Histopathological evaluation showed predominantly METAVIR grade F0 fibrosis at doses of 100 and 200 mg/kgBW. These findings suggest potential hepatoprotective effects of PSPE in this preclinical model of gentamicin-inducedhepatotoxicity.
Co-Authors Evi Lusiana Khairunnisa Rizqika Amanda Putri