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All Journal JURNAL ILMIAH PENELITIAN MAHASISWA Journal of Society Innovation and Development (JSID) Jejak digital: Jurnal Ilmiah Multidisiplin
Rosnizar Rosnizar
Universitas Syiah Kuala
Humanities Computer Science & IT Economics, Econometrics & Finance Education Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Social Sciences Other

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Kajian Literatur: Pemanfaatan Senyawa Fitokimia Tumbuhan sebagai Imunomodulator melalui Penargetan Jalur TNF-α, IL-6, dan NF-κB : - Zahwa Ramadani -; Nidaul Ulfa; Salmina Ulfa; Firdus Firdus; Rosnizar Rosnizar
JURNAL ILMIAH PENELITIAN MAHASISWA Vol 4 No 4 (2026): Agustus
Publisher : Kampus Akademik Publiser

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61722/jipm.v4i4.2539

Abstract

Sistem imun berperan penting dalam mempertahankan homeostasis tubuh melalui regulasi respons terhadap patogen dan kerusakan jaringan. Namun, aktivasi sistem imun yang berlebihan dapat memicu inflamasi kronis yang berkontribusi terhadap berbagai penyakit, seperti artritis reumatoid, diabetes melitus tipe 2, penyakit kardiovaskular, penyakit neurodegeneratif, dan kanker. Pada proses tersebut, Tumor Necrosis Factor-alpha (TNF-α), Interleukin-6 (IL-6), dan Nuclear Factor-kappa B (NF-κB) merupakan mediator utama yang berperan dalam regulasi respons inflamasi sehingga menjadi target potensial dalam pengembangan agen imunomodulator. Senyawa fitokimia tumbuhan diketahui memiliki aktivitas antiinflamasi dan imunomodulator melalui kemampuan memodulasi berbagai jalur pensinyalan inflamasi. Kajian literatur ini bertujuan untuk mengulas potensi senyawa fitokimia tumbuhan sebagai imunomodulator melalui penargetan jalur TNF-α, IL-6, dan NF-κB berdasarkan hasil penelitian in silico menggunakan pendekatan molecular docking. Metode yang digunakan berupa literature review dengan mengumpulkan artikel ilmiah yang dipublikasikan pada periode 2020-2026 dari berbagai basis data, meliputi PubMed, Scopus, ScienceDirect, MDPI, dan Google Scholar. Artikel yang dipilih membahas aktivitas imunomodulator senyawa fitokimia terhadap TNF-α, IL-6, atau NF-κB serta memuat data molecular docking. Hasil kajian menunjukkan bahwa berbagai kelompok fitokimia, seperti flavonoid, alkaloid, terpenoid, senyawa fenolik, dan saponin, memiliki afinitas ikatan yang baik terhadap protein target serta berpotensi menghambat jalur inflamasi melalui berbagai mekanisme molekuler. Selain itu, pendekatan molecular docking terbukti efektif dalam mengidentifikasi kandidat senyawa imunomodulator berbasis bahan alam sebelum dilakukan pengujian eksperimental. Oleh karena itu, senyawa fitokimia tumbuhan berpotensi dikembangkan sebagai agen imunomodulator multitarget yang menargetkan TNF-α, IL-6, dan NF-κB untuk mendukung pengembangan terapi penyakit inflamasi di masa mendatang.
Neuroimmune Dysregulation in Schizophrenia: A Cross-Domain Systematic Review of Developmental, Genetic, and Systemic Sarah Salsabil; Husna Adlin; Firdus Firdus; Rosnizar Rosnizar
JOURNAL OF SOCIETY INNOVATION AND DEVELOPMENT Vol 8 No 1 (2026): JSID: November 2026
Publisher : Winaya Inspirasi Nusantara Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63924/jsid.v8i1.295

Abstract

Schizophrenia affects approximately 1% of the global population. Dopaminergic models have long dominated pathophysiological accounts and the immune system is increasingly recognized as a mechanistically active contributor. However, no comprehensive synthesis of recent cross-domain neuroimmune evidence exists. This systematic review aimed to characterize the scope, quality, and clinical relevance of neuroimmune research in schizophrenia published between 2025 and 2026. Following PRISMA 2020 guidelines, Scopus was searched using 'schizophrenia' AND 'immune system,' yielding 1,497 records. After screening for publication year, document type, and full-text eligibility, 55 peer-reviewed articles were included across ten thematic domains. A convergent neuroimmune signature emerged: pro-inflammatory cytokines were consistently elevated and correlated with symptom severity; the neutrophil-to-lymphocyte ratio independently predicted PANSS scores, suicidal ideation, and hospitalization duration; gestational poly I:C-induced Maternal Immune Activation (MIA) programmed durable immune dysregulation in non-human primate offspring through late adolescence; transcriptome-wide Mendelian randomization identified 196 immune-cell schizophrenia risk genes, with IRF3 enrichment linking the disorder to antiviral pathways; and specific gut microbiota genera (Barnesiella, Desulfovibrio, Gordonibacter, and Romboutsia) exerted causal protective effects via immune-inflammatory mechanisms (OR 0.85–0.93). These findings establish schizophrenia as a disorder with a multifaceted neuroimmune signature spanning developmental, genetic, cellular, and systemic dimensions. The field has advanced from correlational observation to causal inference and therapeutic proof-of-concept, positioning the immune system as a critically underexplored target for next-generation psychiatric treatment and necessitating immune-stratified trial designs alongside routine immunological monitoring in clinical practice.
Interaksi Sistem Imun dan Hematologi dalam Mekanisme Pertahanan Tubuh: Tinjauan Imunobiologi Hilya Saputri; Syalwa Arsa; Firdus Firdus; Rosnizar Rosnizar
Jejak digital: Jurnal Ilmiah Multidisiplin Vol. 2 No. 4 (2026): JUNI-JULI
Publisher : INDO PUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63822/gaawrg68

Abstract

The immune system and the hematological system are closely interconnected biological systems that play essential roles in maintaining homeostasis and protecting the body against pathogens. This study aimed to comprehensively examine the interaction between the immune and hematological systems from an immunobiological perspective. The study employed a literature review method by analyzing scientific articles published between 2015 and 2025 from national and international journals. The findings indicate that leukocytes, platelets, erythrocytes, and plasma components contribute significantly to immune regulation and defense mechanisms. Cellular interactions involving immune cells, inflammatory mediators, and hematopoietic processes facilitate coordinated responses to infection and tissue injury. Platelets participate in immune signaling and inflammation, while erythrocytes contribute to immune modulation through complement interactions and inflammatory regulation. Furthermore, hematological parameters can serve as important indicators of immune responses in infectious and inflammatory diseases. Overall, the integration of immune and hematological systems is crucial for maintaining physiological balance and supporting effective host defense mechanisms. Understanding this relationship may contribute to the development of improved diagnostic, prognostic, and therapeutic strategies for various diseases.
Disregulasi Respon Imun pada Kanker Payudara: Tinjauan Epidemiologi, Subtipe Molekuler, dan Terapi Maula Syakira; Nisa Ulmafhigrah; Firdus Firdus; Rosnizar Rosnizar
Jejak digital: Jurnal Ilmiah Multidisiplin Vol. 2 No. 4 (2026): JUNI-JULI
Publisher : INDO PUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63822/rw6rbs87

Abstract

Breast cancer is the disease with the highest mortality rate in women worldwide. Breast cancer development is influenced not only by the intrinsic characteristics of tumor cells but also by the complex interactions between cancer cells, the immune system, and components of the tumor microenvironment (TME). Dysregulation of the immune response plays a crucial role in disease progression through various mechanisms, including immunosuppression, immune evasion, and altered immune cell function. This article aims to comprehensively examine the mechanisms of immune response dysregulation in breast cancer based on the latest scientific literature. The method used is a literature review by reviewing various relevant research articles and review articles regarding breast cancer molecular subtypes, TME characteristics, the role of immune cells, and factors influencing the immune response in breast cancer. The results of this study indicate that breast cancer molecular subtypes have distinct immunological characteristics that influence disease progression and therapeutic response. A deeper understanding of these mechanisms is expected to support the development of more effective therapeutic strategies, particularly immunotherapy tailored to the patient's biological characteristics.
Co-Authors Firdus Firdus Hilya Saputri Husna Adlin Maula Syakira Nidaul Ulfa Nisa Ulmafhigrah Salmina Ulfa Sarah Salsabil Syalwa Arsa Zahwa Ramadani -