Article Per Year (5 Year)
p-Index From 2021 - 2026
1.518
P-Index
This Author published in this journals
All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Biologi Tropis Jurnal Laot Ilmu Kelautan JURNAL ILMIAH PENELITIAN MAHASISWA Journal of Society Innovation and Development (JSID) MERDEKA: Jurnal Ilmiah Multidisiplin Jejak digital: Jurnal Ilmiah Multidisiplin
Firdus Firdus
Universitas Syiah Kuala
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Physics Social Sciences Other

Published : 10 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 10 Documents
Search

 1 
Literatur Review: Pencemaran Logam Berat di Pelabuhan Indonesia Nanda Muhammad Razi; Fildzah Fildzah; Desy Nurrahma Dhani; Muhammad Nasir; Alia Rizki; Firdus Firdus
Jurnal Laot Ilmu Kelautan Vol 5, No 1 (2023): Jurnal Laot Ilmu Kelautan
Publisher : Universitas Teuku Umar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35308/jlik.v5i1.7175

Abstract

Logam berat merupakan satu dari banyaknya zat yang dapat mengkontaminasi suatu perairan yang tidak dapat dilarutkan bahkan dihilangkan oleh mikroorganisme sehingga dapat menyebabkan penumpukan dan pengendapan hingga ke dasar perairan. Akumulasi logam berat di perairan berdampak pada penurunan kualitas lingkungan yang dapat mengganggu ekosistem dan biota didalamnya seperti terumbu karang ikan karang, makrozobenthos, lamun dan lain-lain. Dampak tersebut menjadi salah satu potensi risiko kesehatan manusia akibat konsumsi ikan dan hidangan laut lainnya yang terakumulasi logam berat. Dalam dua dekade terakhir, penelitian logam berat telah banyak dilakukan oleh peneliti secara global, termasuk penelitian logam berat di Pelabuhan. Penelitian ini mengkaji tingkat kesusaian perairan akibat logam berat berdasarkan standar baku mutu perairan di pelabuhan Indonesia berdasarkan literatur yang tersedia.
The Effect of Adding Water Hyacinth (Eichhornia crassipes) Fermented with Aspergillus niger in Feed on Protein Retention of Tilapia (Orechormis niloticus) Syavira Azzahra; Firdus Firdus; Lenni Fitri
Jurnal Penelitian Pendidikan IPA Vol 11 No 12 (2025): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v11i12.10029

Abstract

Feed is one of the important factors in fish farming, because it can account for 60–70% of the total operational costs of cultivation. The purpose of this study was to analyze the effect of providing water hyacinth (Eichhornia crassipes) fermented with Aspergillus niger as feed on the growth performance of tilapia (Oreochromis niloticus). This study used an experimental method and a Completely Randomized Design (CRD) consisting of five treatments and three replications, with the composition of P0 (commercial pellets) as the control, P1 (30% unfermented water hyacinth flour), and P2 (10%), P3 (20%), and P4 (30%) fermented water hyacinth flour. The results of this study showed that the addition of water hyacinth flour fermented with Aspergillus niger had no significant effect (P > 0.05) on tilapia protein retention. It was also known that the water quality in the tilapia maintenance media was within the optimal range.
Microplastic Pollution in Indonesian Waters: Characteristics, Ecological Impacts, and Mitigation Strategies Fathun Rahman; Fitri Afifah Nasution; Nadya Nadya; Firdus Firdus; Alia Rizki; Muhammad Nasir
Jurnal Biologi Tropis Vol. 26 No. 2 (2026): April - Juni
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v26i2.11897

Abstract

Microplastic pollution in waters poses a serious threat to aquatic ecosystems in Indonesia. This study aims to examine the variations in microplastic types based on shape and polymer, abundance, impacts on aquatic biota, and solutions through literature reviews from various sources. The results indicate that microplastic pollution has spread widely from western to eastern Indonesia. The highest abundance was found in areas with high population density and anthropogenic activity, such as Banten Bay, Jakarta Bay, and the South Coast of Java. Microplastic forms are dominated by fragments, fibers, films, and foams. Polymer identification shows a dominance of PP and PE as well as specific industrial polymers. The impact of contamination occurs on various biota, from fish to invertebrates, causing decreased nutritional quality, digestive damage, and metabolic disorders. Mitigation includes reducing single-use plastics, improving waste management, Wastewater Treatment Plant (WWTP) technology, bioremediation, as well as the role of the community and government policies.
Kajian Literatur: Pemanfaatan Senyawa Fitokimia Tumbuhan sebagai Imunomodulator melalui Penargetan Jalur TNF-α, IL-6, dan NF-κB : - Zahwa Ramadani -; Nidaul Ulfa; Salmina Ulfa; Firdus Firdus; Rosnizar Rosnizar
JURNAL ILMIAH PENELITIAN MAHASISWA Vol 4 No 4 (2026): Agustus
Publisher : Kampus Akademik Publiser

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61722/jipm.v4i4.2539

Abstract

Sistem imun berperan penting dalam mempertahankan homeostasis tubuh melalui regulasi respons terhadap patogen dan kerusakan jaringan. Namun, aktivasi sistem imun yang berlebihan dapat memicu inflamasi kronis yang berkontribusi terhadap berbagai penyakit, seperti artritis reumatoid, diabetes melitus tipe 2, penyakit kardiovaskular, penyakit neurodegeneratif, dan kanker. Pada proses tersebut, Tumor Necrosis Factor-alpha (TNF-α), Interleukin-6 (IL-6), dan Nuclear Factor-kappa B (NF-κB) merupakan mediator utama yang berperan dalam regulasi respons inflamasi sehingga menjadi target potensial dalam pengembangan agen imunomodulator. Senyawa fitokimia tumbuhan diketahui memiliki aktivitas antiinflamasi dan imunomodulator melalui kemampuan memodulasi berbagai jalur pensinyalan inflamasi. Kajian literatur ini bertujuan untuk mengulas potensi senyawa fitokimia tumbuhan sebagai imunomodulator melalui penargetan jalur TNF-α, IL-6, dan NF-κB berdasarkan hasil penelitian in silico menggunakan pendekatan molecular docking. Metode yang digunakan berupa literature review dengan mengumpulkan artikel ilmiah yang dipublikasikan pada periode 2020-2026 dari berbagai basis data, meliputi PubMed, Scopus, ScienceDirect, MDPI, dan Google Scholar. Artikel yang dipilih membahas aktivitas imunomodulator senyawa fitokimia terhadap TNF-α, IL-6, atau NF-κB serta memuat data molecular docking. Hasil kajian menunjukkan bahwa berbagai kelompok fitokimia, seperti flavonoid, alkaloid, terpenoid, senyawa fenolik, dan saponin, memiliki afinitas ikatan yang baik terhadap protein target serta berpotensi menghambat jalur inflamasi melalui berbagai mekanisme molekuler. Selain itu, pendekatan molecular docking terbukti efektif dalam mengidentifikasi kandidat senyawa imunomodulator berbasis bahan alam sebelum dilakukan pengujian eksperimental. Oleh karena itu, senyawa fitokimia tumbuhan berpotensi dikembangkan sebagai agen imunomodulator multitarget yang menargetkan TNF-α, IL-6, dan NF-κB untuk mendukung pengembangan terapi penyakit inflamasi di masa mendatang.
Neuroimmune Dysregulation in Schizophrenia: A Cross-Domain Systematic Review of Developmental, Genetic, and Systemic Sarah Salsabil; Husna Adlin; Firdus Firdus; Rosnizar Rosnizar
JOURNAL OF SOCIETY INNOVATION AND DEVELOPMENT Vol 8 No 1 (2026): JSID: November 2026
Publisher : Winaya Inspirasi Nusantara Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63924/jsid.v8i1.295

Abstract

Schizophrenia affects approximately 1% of the global population. Dopaminergic models have long dominated pathophysiological accounts and the immune system is increasingly recognized as a mechanistically active contributor. However, no comprehensive synthesis of recent cross-domain neuroimmune evidence exists. This systematic review aimed to characterize the scope, quality, and clinical relevance of neuroimmune research in schizophrenia published between 2025 and 2026. Following PRISMA 2020 guidelines, Scopus was searched using 'schizophrenia' AND 'immune system,' yielding 1,497 records. After screening for publication year, document type, and full-text eligibility, 55 peer-reviewed articles were included across ten thematic domains. A convergent neuroimmune signature emerged: pro-inflammatory cytokines were consistently elevated and correlated with symptom severity; the neutrophil-to-lymphocyte ratio independently predicted PANSS scores, suicidal ideation, and hospitalization duration; gestational poly I:C-induced Maternal Immune Activation (MIA) programmed durable immune dysregulation in non-human primate offspring through late adolescence; transcriptome-wide Mendelian randomization identified 196 immune-cell schizophrenia risk genes, with IRF3 enrichment linking the disorder to antiviral pathways; and specific gut microbiota genera (Barnesiella, Desulfovibrio, Gordonibacter, and Romboutsia) exerted causal protective effects via immune-inflammatory mechanisms (OR 0.85–0.93). These findings establish schizophrenia as a disorder with a multifaceted neuroimmune signature spanning developmental, genetic, cellular, and systemic dimensions. The field has advanced from correlational observation to causal inference and therapeutic proof-of-concept, positioning the immune system as a critically underexplored target for next-generation psychiatric treatment and necessitating immune-stratified trial designs alongside routine immunological monitoring in clinical practice.
Dampak Toksisitas Limbah Industri Tekstil Terhadap Kualitas Air dan Biota Akuatik Syalwa Arsa; Ulli Zahrati; Firdus Firdus; Muhammad Nasir; Alia Rizki
Jejak digital: Jurnal Ilmiah Multidisiplin Vol. 2 No. 3 (2026): MEI 2026
Publisher : INDO PUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63822/vsxjzs65

Abstract

The development of the textile industry makes a significant contribution to the economy, but its production activities also generate large amounts of liquid waste that has the potential to pollute aquatic environments. Textile industrial waste generally contains various hazardous substances such as synthetic dyes, organic chemicals, surfactants, and heavy metals like chromium, which can degrade water quality and cause toxic effects on aquatic organisms. This article aims to analyze the performance of textile industrial waste, examine its effects on water quality parameters, and assess its toxicity to aquatic biota. The method used is a literature review of various scientific journal sources related to textile waste and its impact on marine ecosystems. The results show that textile waste can increase BOD, COD, turbidity, and suspended solids content, thereby reducing dissolved oxygen levels in water. This condition can cause physiological stress, growth disorders, and even death of aquatic organisms. Furthermore, heavy metals and synthetic dyes in textile waste have the potential to bioaccumulate and biomagnify in the food chain, threatening the balance of marine ecosystems and human health. Therefore, effective management and treatment of textile industrial waste is crucial to reduce the impact of pollution and protect the aquatic environment.
Dinamika Resistensi Antimikroba dan Dampak Ekotoksikologi Limbah Cair Rumah Sakit terhadap Ekosistem Kartini Amelia Putri; Mirryazil Jannah; Nadisa Azzahra; Firdus Firdus; Muhammad Nasir; Alia Rizki
Jejak digital: Jurnal Ilmiah Multidisiplin Vol. 2 No. 3 (2026): MEI 2026
Publisher : INDO PUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63822/rn974z97

Abstract

Antimicrobial resistance and environmental pollution from hospital wastewater are global problems that threaten human health and ecosystems. Wastewater from healthcare facilities contains pathogenic microorganisms, antibiotic residues, resistance genes, as well as chemical pollutants that cannot be completely removed by conventional waste treatment systems. The research method was conducted based on a literature review, including experimental approaches, field surveys, and literature studies. The results of the study indicate that the presence of biofilms in drainage channels serves as a major reservoir for multi-drug resistant (MDR) bacteria and facilitates horizontal transfer of resistance genes, accelerating the emergence of increasingly resistant microbial strains. Non-antibiotic pollutants such as analgesic drugs and caffeine also affect the composition of the wastewater microbiome and increase the risk of pathogen growth and resistance. The toxicological impacts of this pollution can cause oxidative stress and tissue damage in aquatic organisms, as well as serious problems in the food chain cycle. Conventional waste treatment often cannot filter all residues and resistance genes, thus requiring the application of more advanced treatment technologies such as advanced oxidation and the use of nanomaterials. To reduce this risk, hospital waste management must be conducted systematically and scientifically, including controlling the rational use of antibiotics and improving the effectiveness of wastewater treatment systems. This approach is important to protect public health, maintain the sustainability of aquatic ecosystems, and prevent the widespread spread of antibiotic resistance.
Interaksi Sistem Imun dan Hematologi dalam Mekanisme Pertahanan Tubuh: Tinjauan Imunobiologi Hilya Saputri; Syalwa Arsa; Firdus Firdus; Rosnizar Rosnizar
Jejak digital: Jurnal Ilmiah Multidisiplin Vol. 2 No. 4 (2026): JUNI-JULI
Publisher : INDO PUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63822/gaawrg68

Abstract

The immune system and the hematological system are closely interconnected biological systems that play essential roles in maintaining homeostasis and protecting the body against pathogens. This study aimed to comprehensively examine the interaction between the immune and hematological systems from an immunobiological perspective. The study employed a literature review method by analyzing scientific articles published between 2015 and 2025 from national and international journals. The findings indicate that leukocytes, platelets, erythrocytes, and plasma components contribute significantly to immune regulation and defense mechanisms. Cellular interactions involving immune cells, inflammatory mediators, and hematopoietic processes facilitate coordinated responses to infection and tissue injury. Platelets participate in immune signaling and inflammation, while erythrocytes contribute to immune modulation through complement interactions and inflammatory regulation. Furthermore, hematological parameters can serve as important indicators of immune responses in infectious and inflammatory diseases. Overall, the integration of immune and hematological systems is crucial for maintaining physiological balance and supporting effective host defense mechanisms. Understanding this relationship may contribute to the development of improved diagnostic, prognostic, and therapeutic strategies for various diseases.
Disregulasi Respon Imun pada Kanker Payudara: Tinjauan Epidemiologi, Subtipe Molekuler, dan Terapi Maula Syakira; Nisa Ulmafhigrah; Firdus Firdus; Rosnizar Rosnizar
Jejak digital: Jurnal Ilmiah Multidisiplin Vol. 2 No. 4 (2026): JUNI-JULI
Publisher : INDO PUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63822/rw6rbs87

Abstract

Breast cancer is the disease with the highest mortality rate in women worldwide. Breast cancer development is influenced not only by the intrinsic characteristics of tumor cells but also by the complex interactions between cancer cells, the immune system, and components of the tumor microenvironment (TME). Dysregulation of the immune response plays a crucial role in disease progression through various mechanisms, including immunosuppression, immune evasion, and altered immune cell function. This article aims to comprehensively examine the mechanisms of immune response dysregulation in breast cancer based on the latest scientific literature. The method used is a literature review by reviewing various relevant research articles and review articles regarding breast cancer molecular subtypes, TME characteristics, the role of immune cells, and factors influencing the immune response in breast cancer. The results of this study indicate that breast cancer molecular subtypes have distinct immunological characteristics that influence disease progression and therapeutic response. A deeper understanding of these mechanisms is expected to support the development of more effective therapeutic strategies, particularly immunotherapy tailored to the patient's biological characteristics.
FAKTOR PROGNOSIS DAN PERKEMBANGAN TERAPI LEUKEMIA LIMFOBLASTIK AKUT (LLA) PADA ANAK DI INDONESIA: ARTIKEL REVIEW Hilal Zhumadhil Murtala; Fathun Rahman; Firdus Firdus; Rosnizar
MERDEKA : Jurnal Ilmiah Multidisiplin Vol. 3 No. 5 (2026): Juni
Publisher : PT PUBLIKASI INSPIRASI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62017/merdeka.v3i5.7984

Abstract

Leukemia Limfoblastik Akut (LLA) merupakan keganasan hematologi yang paling sering terjadi pada anak dan menjadi penyebab utama kematian akibat kanker di negara berkembang. Review artikel ini bertujuan menganalisis faktor prognostik serta perkembangan terapi LLA pada anak di Indonesia melalui kajian literatur dari publikasi tahun 2016–2026. Hasil penelitian menunjukkan bahwa prognosis pasien dipengaruhi oleh jumlah leukosit awal, usia saat diagnosis, status gizi, respons terhadap terapi induksi, serta kelainan genetik dan sitogenetik. Selain itu, keterlambatan diagnosis, ketidakpatuhan terapi, dan keterbatasan fasilitas kesehatan masih menjadi tantangan dalam meningkatkan angka kesintasan. Perkembangan imunoterapi dan terapi yang ditargetkan memberikan harapan baru dalam meningkatkan keberhasilan pengobatan, termasuk pada kelompok risiko tinggi. Integrasi pendekatan klinis, molekuler, dan pelayanan kesehatan yang optimal diperlukan untuk meningkatkan kualitas hidup serta prognosis pasien anak dengan LLA.
Co-Authors Alia Rizki Desy Nurrahma Dhani Fathun Rahman Fildzah Fildzah Fitri Afifah Nasution Hilal Zhumadhil Murtala Hilya Saputri Husna Adlin Kartini Amelia Putri Lenni Fitri Maula Syakira Mirryazil Jannah Muhammad Nasir Nadisa Azzahra Nadya Nadya Nanda Muhammad Razi Nidaul Ulfa Nisa Ulmafhigrah Rosnizar Rosnizar Rosnizar, Rosnizar Salmina Ulfa Sarah Salsabil Syalwa Arsa Syavira Azzahra Ulli Zahrati Zahwa Ramadani -