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All Journal Indonesian Journal of Cancer Gema Lingkungan Kesehatan
Suhartono Suhartono
Department of Environmental Health, Faculty of Public Health, Universitas Diponegoro, Semarang, Indonesia
Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Occupational Pesticide Exposure and Reduced eGFR in Farmers Hansen Hansen; Mursid Raharjo; Suhartono Suhartono; Nur Endah Wahyuningsih
Gema Lingkungan Kesehatan Vol. 24 No. 2 (2026): Gema Lingkungan Kesehatan
Publisher : Poltekkes Kemenkes Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36568/gelinkes.v24i2.499

Abstract

Pesticides are frequently utilized in modern farming to sustain crop productivity. However, improper use may pose occupational health risks, including chronic renal toxicity. In Indonesia, evidence regarding long-term kidney effects among farmers remains limited. This study aimed to determine the prevalence of reduced estimated glomerular filtration rate (eGFR) and examine its association with pesticide exposure among horticultural farmers in Wanasari District, Brebes Regency. A cross-sectional analytical study was conducted among 367 farmers aged 18-63 years. Data on pesticide use, personal protective equipment (PPE), smoking habits, health complaints, and hypertension were collected through interviews. Serum creatinine levels were measured enzymatically and used to estimate eGFR. Multivariate logistic regression analysis was applied to identify factors associated with reduced renal function. Several variables showed a significant association with decreased renal function, namely smoking status (OR = 2.972; 95% CI: 1.299-6.001; p = 0.009), pesticide dosage (OR = 4.555; 95% CI: 2.415-8.291; p < 0.001), PPE use (OR = 0.383; 95% CI: 0.199-0.737; p = 0.004), health complaints (OR = 2.972; 95% CI: 1.567-5.636; p = 0.001), hypertension (OR = 2.367; 95% CI: 1.278-4.382; p = 0.006), working period (OR = 15.057; 95% CI: 3.510-64.591; p < 0.001). Working period was the dominant factor associated with decreased kidney function in farmers. This indicates the importance of chronic exposure duration in increasing the risk of pesticide-induced nephrotoxicity. Prevention efforts should focus on controlling exposure duration, improving adherence to PPE use, providing education on pesticide use, and regularly monitoring kidney function.
Sonoelastography Findings in Breast Cancer: Correlation with Molecular Subtypes and Ki-67 Expression Lydia Purna Kuntjoro; Ignatius Riwanto; Hermina Sukmaningtyas; Yan Wisnu Prajoko; Suhartono Suhartono; Lina Choridah; Endang Mahati; Clarissa Aulia Pravitha
Indonesian Journal of Cancer Vol. 20 No. 2 (2026): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i2.1503

Abstract

Background: Strain elastography is increasingly used as a complementary imaging tool to assess suspicious breast lesions by evaluating tissue stiffness using the strain ratio and elastography score. Owing to the intertumor heterogeneity of breast cancer, this study aimed to investigate the association between elastography findings and tumor proliferation, as indicated by Ki-67 expression, across different molecular subtypes.Methods: This cross-sectional study prospectively collected data from three hospitals, including Dr. Kariadi Hospital, National Diponegoro Hospital, and Ken Saras Hospital. Patients with BI-RADS ultrasound category 4 or 5 lesions confirmed as malignant on histopathology were included. The elastography score was assessed using the Tsukuba elasticity score, while the strain ratio was calculated by comparing the strain elasticity within a lesion with that within the adjacent normal tissue. Independent t-tests and chi-square tests were employed to assess the correlation between elastography findings and gold standard tests, such as molecular subtype and immunohistochemical results. The most significant results were further evaluated for their diagnostic performance. Data were analyzed using SPSS version 25. Results: This study included 29 patients with a mean age of 52.06 ± 11.99 years. The associations between immunohistochemical markers and both the strain ratio and elastography score did not reach statistical significance, possibly due to the limited sample size. Among molecular subtypes, only luminal B demonstrated a significant association with the strain ratio (p = 0.025). Diagnostic evaluation for luminal B yielded a sensitivity of 61.1%, specificity of 81.8%, and an area under the curve (AUC) of 0.689 at a strain ratio cutoff of 4.27.Conclusions: Increased stiffness in the luminal B subtype suggests the potential of strain elastography as a noninvasive indicator of tumor behavior
Co-Authors Clarissa Aulia Pravitha Endang Mahati Hansen Hansen Hermina Sukmaningtyas Ignatius Riwanto Lina Choridah Lydia Purna Kuntjoro Mursid Raharjo Nur Endah Wahyuningsih Yan Wisnu Prajoko