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All Journal Jurnal Kedokteran Diponegoro Indonesian Journal of Cancer
Hermina Sukmaningtyas
Department of Radiology, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health

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ANALYSIS OF RISK FACTORS AFFECTING LUMBAL FACET JOINT OSTEOARTHRITIS IN MRI SCAN Aulia Anastasia; Hermina Sukmaningtyas; Agus Priambodo; Erna Setiawati
JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL) Vol 11, No 1 (2022): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v11i1.32588

Abstract

Background: Osteoarthritis is a long-term, chronic disease that is usually marked by cartilage degeneration in the joints, which in turn induces bone friction. One of the subtype of this disease is facet joint osteoarthritis or in short, FJOA. In Indonesia, FJOA has not been commonly documented. The most common method for FJOA inspection is X-Ray modality. The usage of other radiology imaging, such as CT-Scan or MRI, are also used to evaluate erosion, osteophyte creation, subchondral sclerosis, and joint constriction. Nevertheless, the most ideal FJOA inspection method is still an ongoing debate due to strengths and weaknesses of each methods. CT scans are more widely used than MRIs and are typically less expensive. MRIs, however, are thought to be superior in regards to the detail of the image. Objective: To understand the effect of age, sex, and spinal level towards FJOA on MRI scanning. Method: This research used cross-sectional approach. Sample taken in this research were all radiology results from patients that fulfills inclusion criteria and had gone through MRI inspection in Jatinegara Premier Hospital. Age, sex, disk degeneration degree, and spinal level are the main focus for this study since those are the most common risk factor for FJOA. Results: 46.8% of FJOA were found in male patients while the other 53.2% were found in females. L4-5 and Grade 1 FJOA had the highest incidence found, with the amount of 29% and 48.4% respectively. There was no correlation between sex and FJOA degree based on Asymp. Sig of 0.255. There was also no correlation between age and FJOA degree based on Asymp. Sig of 0.702. However, there was a correlation between spinal level and disk degeneration degree with FJOA degree due to Asymp. Sig <0.05.  Conclusion: There was no significant relationship between age and sex to lumbar facet joint osteoarthritis and there was a significant relationship between spinal level and disk degeneration degree with lumbar facet joint osteoarthritis.
Sonoelastography Findings in Breast Cancer: Correlation with Molecular Subtypes and Ki-67 Expression Lydia Purna Kuntjoro; Ignatius Riwanto; Hermina Sukmaningtyas; Yan Wisnu Prajoko; Suhartono Suhartono; Lina Choridah; Endang Mahati; Clarissa Aulia Pravitha
Indonesian Journal of Cancer Vol. 20 No. 2 (2026): June
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v20i2.1503

Abstract

Background: Strain elastography is increasingly used as a complementary imaging tool to assess suspicious breast lesions by evaluating tissue stiffness using the strain ratio and elastography score. Owing to the intertumor heterogeneity of breast cancer, this study aimed to investigate the association between elastography findings and tumor proliferation, as indicated by Ki-67 expression, across different molecular subtypes.Methods: This cross-sectional study prospectively collected data from three hospitals, including Dr. Kariadi Hospital, National Diponegoro Hospital, and Ken Saras Hospital. Patients with BI-RADS ultrasound category 4 or 5 lesions confirmed as malignant on histopathology were included. The elastography score was assessed using the Tsukuba elasticity score, while the strain ratio was calculated by comparing the strain elasticity within a lesion with that within the adjacent normal tissue. Independent t-tests and chi-square tests were employed to assess the correlation between elastography findings and gold standard tests, such as molecular subtype and immunohistochemical results. The most significant results were further evaluated for their diagnostic performance. Data were analyzed using SPSS version 25. Results: This study included 29 patients with a mean age of 52.06 ± 11.99 years. The associations between immunohistochemical markers and both the strain ratio and elastography score did not reach statistical significance, possibly due to the limited sample size. Among molecular subtypes, only luminal B demonstrated a significant association with the strain ratio (p = 0.025). Diagnostic evaluation for luminal B yielded a sensitivity of 61.1%, specificity of 81.8%, and an area under the curve (AUC) of 0.689 at a strain ratio cutoff of 4.27.Conclusions: Increased stiffness in the luminal B subtype suggests the potential of strain elastography as a noninvasive indicator of tumor behavior
Co-Authors Agus Priambodo Aulia Anastasia Clarissa Aulia Pravitha Endang Mahati Erna Setiawati Ignatius Riwanto Lina Choridah Lydia Purna Kuntjoro Suhartono Suhartono Yan Wisnu Prajoko