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Validity of BI-RADS System Mammography to detect breast cancer at Dr Sardjito Hospital Yogyakarta Teguh Aryandono, Indrasto Histopaedianto Lina Choridah
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 01 (2008)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Breast cancer is the second most common cancer among women worldwide and the sixth common cause of mortality in Indonesia. The diagnosis of breast cancer may be established by physical and imaging examinations, but definitive diagnosis should be verified by histopathologic examination. Mammography is an easy non-invasive imaging method to detect breast cancer with good accuracy. The lack of uniformity in mammography reporting has led to confusion as to the interpretation and management recommendation. The American College of Radiology Breast Imaging Reporting and Data System (BIRADS) has provided a standardized reporting system for mammography. The validity of this system at Dr Sardjito Hospital Yogyakarta has not been evaluated.Objective: To know the sensitivity, specificity, positive and negative predictive values, and accuracy of the BI-RADS System Mammography in diagnosing breast cancer.Methods: This study was a diagnostic test with cross sectional design on breast cancer diagnosis based on BI-RADS system mammography. All medical record files of patients with breast lump who underwent mammography and histopatologic examination, at Dr Sardjito Hospital Yogyakarta between December 2003-March 2008, were included in the analysis.Results: BI-RADS System Mammography at Dr Sardjito Hospital Yogyakarta had sensitivity of 87.5%, specificity of 93.7%, positive predictive value of 96.5%, negative predictive value 78.95%, positive likelihood ratio 14, negative likelihood ratio 0.13, prevalence 66.6%, and accuracy 89.6%.Conclusion: Mammography examination using BI-RADS System in Sardjito Hospital Yogyakarta was favourable in detecting breastcancer.Key words: breast cancer - BI-RADS mammography - histopathology - diagnostic value

The Cytogenetic Effects on Peripheral Blood Lymphocytes in Cancer Patients After Radiation Therapy: Chromosome Aberrations and Micronuclei Lusiyanti, Yanti; Surniyantoro, Harry Nugroho Eko; Rahajeng, Nastiti; Suvifan, Viria Agesti; Purnami, Sofiati; Choridah, Lina
Biosaintifika: Journal of Biology & Biology Education Vol 13, No 1 (2021): April 2021
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v13i1.25264

Individual responses to radiotherapy are often observed whether or not regimes with identical treatments were applied. Patient-related factors, the therapeutic process, and therefore the intrinsic factors of individual radiosensitivity are considered to be causing the variability of side effects. A preliminary evaluation was done on cytogenetic biomarkers found in cancer patients. The purpose of this present study was to assess the individual response of patients with cancers after radiation therapy. The sample obtained from 11 patients with different types of cancer as a case group and 12 people as a control group from a healthy volunteer. Blood samples were stimulated by an in vitro culture using phytohemagglutinin, and the cultures were assessed by using the Dicentric and Cytokinesis- Block Micronucleus (CBMN-) assay. These two methods were compared. The results showed that the overall dicentric chromosome and micronuclei in binucleate cells (MN/BNC) have a significantly higher frequency in the breast, head, and neck compared to extremity cancer. A high frequency of micronuclei in lymphocyte patients was seen after radiotherapy treatment but relatively not much higher compared to the range of micronuclei backgrounds in healthy people The CBMN is the most effective assay for evaluation of the cytogenetic studies in cancer patients because it is more radiosensitive to study individual responses. By evaluating the effects of radiotherapy based on DNA damage, the severity of radiation exposure can be studied. This study can be useful for researchers and related stakeholders in the application of radiotherapy.

Feature Selection Mammogram based on Breast Cancer Mining Shofwatul Uyun; Lina Choridah
International Journal of Electrical and Computer Engineering (IJECE) Vol 8, No 1: February 2018
Publisher : Institute of Advanced Engineering and Science

The very dense breast of mammogram image makes the Radiologists often have difficulties in interpreting the mammography objectively and accurately. One of the key success factors of computer-aided diagnosis (CADx) system is the use of the right features. Therefore, this research emphasizes on the feature selection process by performing the data mining on the results of mammogram image feature extraction. There are two algorithms used to perform the mining, the decision tree and the rule induction. Furthermore, the selected features produced by the algorithms are tested using classification algorithms: k-nearest neighbors, decision tree, and naive bayesian with the scheme of 10-fold cross validation using stratified sampling way. There are five descriptors that are the best features and have contributed in determining the classification of benign and malignant lesions as follows: slice, integrated density, area fraction, model gray value, and center of mass. The best classification results based on the five features are generated by the decision tree algorithm with accuracy, sensitivity, specificity, FPR, and TPR of 93.18%; 87.5%; 3.89%; 6.33% and 92.11% respectively.

Validity of BI-RADS System Mammography to detect breast cancer at Dr Sardjito Hospital Yogyakarta Indrasto Histopaedianto Lina Choridah Teguh Aryandono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 40, No 01 (2008)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Background: Breast cancer is the second most common cancer among women worldwide and the sixth common cause of mortality in Indonesia. The diagnosis of breast cancer may be established by physical and imaging examinations, but definitive diagnosis should be verified by histopathologic examination. Mammography is an easy non-invasive imaging method to detect breast cancer with good accuracy. The lack of uniformity in mammography reporting has led to confusion as to the interpretation and management recommendation. The American College of Radiology Breast Imaging Reporting and Data System (BIRADS) has provided a standardized reporting system for mammography. The validity of this system at Dr Sardjito Hospital Yogyakarta has not been evaluated.Objective: To know the sensitivity, specificity, positive and negative predictive values, and accuracy of the BI-RADS System Mammography in diagnosing breast cancer.Methods: This study was a diagnostic test with cross sectional design on breast cancer diagnosis based on BI-RADS system mammography. All medical record files of patients with breast lump who underwent mammography and histopatologic examination, at Dr Sardjito Hospital Yogyakarta between December 2003-March 2008, were included in the analysis.Results: BI-RADS System Mammography at Dr Sardjito Hospital Yogyakarta had sensitivity of 87.5%, specificity of 93.7%, positive predictive value of 96.5%, negative predictive value 78.95%, positive likelihood ratio 14, negative likelihood ratio 0.13, prevalence 66.6%, and accuracy 89.6%.Conclusion: Mammography examination using BI-RADS System in Sardjito Hospital Yogyakarta was favourable in detecting breastcancer.Key words: breast cancer - BI-RADS mammography - histopathology - diagnostic value

Mammographic Density and Estrogen Receptor α Gene Polymorphism in Javanese Women Lina Choridah; Teguh Aryandono; Arif Faisal; Ahmad Hamim Sadewa; Dewajani Purnomosari
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 49, No 2 (2017)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Estrogen plays important roles in breast cancer as it binds its receptor in breast tissue. The most studied variants in estrogen receptor α encoded by ESR1 gene are the ESR1 PvuII and XbaI polymorphisms, which were associated with lower sensitivity to estrogen. We determined the proportion of ESR1 XbaI and PvuII polymorphisms in Javanese woman in Yogyakarta, Indonesia and analyzed the correlation between genetic variations with mammogram density. ESR1 XbaI and PvuII polymorphisms of 50 cases and 58 controls were identified using PCR-RFLP. Breast density was assessed based on digitizer mammograms. Quantitative analysis was performed using an interactive program based on cumulus of two thresholds. Mean of density and frequencies of SNPs were compared between cases and controls to identify the association between SNPs and cancer susceptibility. Mammographic density was significantly higher in cases (52%) than controls (0.41%) (p < 0.05). Women with one or two copies of the PvuII T allele and XbaI A allele had higher mammographic density compared with women with C and G alleles, respectively. The proportion between PP and TT genotype was not statistically significant (p > 0.05), while the proportion between AA and GG was significantly different (p < 0.05). Haplotype 2 (CG/PX) was associated with lower sensitivity to estrogen and reflects a decrease of mammographic density. These findings were consistent with other studies that showed that ESR1 polymorphisms may affect breast cancer risk through differences in breast density.

Detection of lung disease using relative reconstruction method in electrical impedance tomography system Lina Choridah; Riries Rulaningtyas; Lailatul Muqmiroh; Suprayitno Suprayitno; Khusnul Ain
Bulletin of Electrical Engineering and Informatics Vol 12, No 4: August 2023
Publisher : Institute of Advanced Engineering and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11591/eei.v12i4.4940

Lung disease can be diagnosed with the image-based medical devices, including radiography, computed tomography, and magnetic resonance imaging. The devices are very expensive and have negative effects. An alternative device is electrical impedance tomography (EIT). The advantages of EIT arelow cost, fast, real-time, and free radiation, so it is very appropriate to be used as a monitoring device. The relative reconstruction method has succeeded in producing functional images of lung anomalies by simulation. In this study, the relative reconstruction method was used to obtain functional images of four lungs conditions, namely a healthy person, patient with left lung tumor with organized left pleural effusion, one with pulmonary tuberculosis with right pneumothorax and one with pulmonary tuberculosis with left pleural effusion. The relative reconstruction method can be used to obtain functional images of an individual’s lung conditions by using expiratory-respiratory potential data with results that can distinguish between the lungs of a healthy person and a diseased patient, but the position of the lung disease may have less details. The potential data from comparison between the data of a patient and a healthy person can be used as a reference to obtain more accurate functional image information of lung disease.

THE CONCORDANCE OF BRIXIA AND RALE SCORES IN EVALUATION OF COVID-19 PNEUMONIA PATIENT USING RADIOGRAPHY IN INDONESIA REFERRAL HOSPITAL Lina Choridah; Anita Ekowati; Nurhuda Hendra Setyawan; Bestari Ariningrum Setyawati; Naela Himayati Afifah; Anggraeni Ayu Rengganis
Jurnal Riset Kesehatan Vol 12, No 1 (2023): MAY 2023
Publisher : Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/jrk.v12i1.9333

The COVID-19 pandemic has put intense pressure on the healthcare systems. As the lung complication of COVID-19, pneumonia can be assessed by chest radiography which can be used to predict the severity of patient deterioration using Brixia and RALE scores. This research aims to assess the Radiologists' agreement on diagnosing pneumonia COVID-19 by RT-PCR in CXR using the Brixia and RALE score at Dr. Sardjito Central General Hospital from May 2020-January 2021. Two separate radiologists scored initial chest radiographs for RALE and Brixia independently. The analysis assessed included a descriptive analysis of demographic data, and Bland-Altman plots were used to visualize intra-observer agreement. A total of 332 samples were 162 men (48.8%) and 170 women (51.2%), with a mean age of 42.37. The ICC of Brixia score (0.855, CI:0.794-0.895) and RALE score (0.756, CI:0.662-0.812). Bland–Altman analysis revealed a bias of 5.08 ± 6.04 (95% limits of agreement of -6.760 and 16.929) for Brixia and RALE scores and significantly correlated (r=0.886 (p0.05)). The average score of Brixia (6.29±4.430) and RALE (11.56±9.997) in men was higher than in women. The agreement of Radiologists in diagnosing pneumonia COVID-19 using Brixia and RALE scores with the Bland Altman curve was significant or reliable.

Smoothing Module for Optimization Cranium Segmentation Using 3D Slicer Gilang Argya Dyaksa; Nur Arfian; Herianto Herianto; Lina Choridah; Yosef Agung Cahyanta
International Journal of Applied Sciences and Smart Technologies Volume 05, Issue 01, June 2023
Publisher : Universitas Sanata Dharma

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/ijasst.v5i1.6300

Anatomy is the most essential course in health and medical education to study parts of human body and also the function of it. Cadaver is a media used by medical student to study anatomical subject. Because of limited access to cadaver and also due to high prices, this situation makes it necessary to develope an alternative anatomical education media, one of them is the use 3D printing to produce anatomical models. Before 3D Print the cranium, it is necessary to do the segmentation process and often the segmentation result is not good enough and appear a lot of noises. The purpose of this research is to optimize a 3D cranium based on DICOM (digital imaging and communications in medicine) data processing using the smoothing modules on 3D Slicer. The method of this research is to process the Cranium DICOM data using 3D Slicer software by varying the 5 types of smoothing modules. The results with default parameter fill holes and median have better results compared to others. Kernel size variations are performed for smoothing module fill holes and medians. The result is fill holes get optimal segmentation results using a kernel size of 3 mm and the median is 5 mm

Correlation between the degree of leukoaraiosis and hyperlipidemia in post-ischemic stroke patients Dian Angraeni; Lina Choridah; Evi Artsini
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 55, No 2 (2023)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19106/JMedSci005502202304

Leukoaraiosis is a neurological imaging in the periventricular area and the centrum semiovale. This condition occurs due to abnormalities in the small blood vessels in the brain that lead to hypoxia. It is often observed in patients with ischemic stroke and accompanied by risk factors for hyperlipidemia. This study aimed to evaluate the correlation between the degree of leukoaraiosis and hyperlipidemia in post-ischemic stroke patients. A cross-sectional study retrospectively was conducted on post-ischemic stroke patients who underwent brain MRI (magnetic resonance imaging) on T2 and FLAIR (fluid-attenuated inversion recovery) sequence at the Department of Radiology, Dr. Sardjito General Hospital, Yogyakarta, from January 2021 to March 2022. A total of 36 patients were involved in this study. The leukoaraiosis of patient was examined by brain MRI. Degree of the leukoaraiosis was determined based on Fazekas classification. Serum cholesterol, HDL (high-density lipoprotein), LDL (low-density lipoprotein), and triglyceride levels of patients were then examined. The data obtained were then analyzed using Spearman correlation test. A positive correlation was observed between the degree of leukoaraiosis and triglyceride level (p = 0.042; r = 0.292) and age (p= 0.004; r = 0.464). However, no correlation was observed between the degree of leukoaraiosis and cholesterol, HDL, and LDL (p>0.05). In conclusion, the leukoaraiosis degree is correlated with serum triglyceride levels and age in post-ischemic stroke patients.

The Cytogenetic Effects on Peripheral Blood Lymphocytes in Cancer Patients After Radiation Therapy: Chromosome Aberrations and Micronuclei Yanti Lusiyanti; Harry Nugroho Eko Surniyantoro; Nastiti Rahajeng; Viria Agesti Suvifan; Sofiati Purnami; Lina Choridah
Biosaintifika: Journal of Biology & Biology Education Vol 13, No 1 (2021): April 2021
Publisher : Department of Biology, Faculty of Mathematics and Sciences, Semarang State University . Ro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/biosaintifika.v13i1.25264

Individual responses to radiotherapy are often observed whether or not regimes with identical treatments were applied. Patient-related factors, the therapeutic process, and therefore the intrinsic factors of individual radiosensitivity are considered to be causing the variability of side effects. A preliminary evaluation was done on cytogenetic biomarkers found in cancer patients. The purpose of this present study was to assess the individual response of patients with cancers after radiation therapy. The sample obtained from 11 patients with different types of cancer as a case group and 12 people as a control group from a healthy volunteer. Blood samples were stimulated by an in vitro culture using phytohemagglutinin, and the cultures were assessed by using the Dicentric and Cytokinesis- Block Micronucleus (CBMN-) assay. These two methods were compared. The results showed that the overall dicentric chromosome and micronuclei in binucleate cells (MN/BNC) have a significantly higher frequency in the breast, head, and neck compared to extremity cancer. A high frequency of micronuclei in lymphocyte patients was seen after radiotherapy treatment but relatively not much higher compared to the range of micronuclei backgrounds in healthy people The CBMN is the most effective assay for evaluation of the cytogenetic studies in cancer patients because it is more radiosensitive to study individual responses. By evaluating the effects of radiotherapy based on DNA damage, the severity of radiation exposure can be studied. This study can be useful for researchers and related stakeholders in the application of radiotherapy.

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