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All Journal JFL : Jurnal Farmasi Lampung Jurnal Ilmu Kedokteran dan Kesehatan
Dwi Susanti
Program Studi Teknik Biomedis, Fakultas Teknologi Industri, Institut Teknologi Sumatera
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Perbandingan Daya Hambat Ekstrak Ekstrak Daun Dan Ranting Tanaman Ungu (Graptophyllum pictum (L.) Griff) Terhadap Escherichia coli Dengan Metode Difusi Cakram Dita Dwi Amanda; Putri Amalia; Dwi Susanti
Jurnal Ilmu Kedokteran dan Kesehatan Vol 13, No 5 (2026): Volume 13 Nomor 5
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jikk.v13i5.24554

Abstract

Diare merupakan salah satu penyebab utama kesakitan dan kematian, terutama pada anak-anak. Salah satu bakteri patogen penyebab diare adalah Escherichia coli. Penggunaan antibiotik secara tidak tepat dapat meningkatkan resistensi bakteri, sehingga diperlukan alternatif pengobatan alami. Tanaman ungu (Graptophyllum pictum (L.) Griff) diketahui mengandung senyawa metabolit sekunder seperti flavonoid, tanin, terpenoid, steroid, fenolik, dan alkaloid yang berpotensi sebagai antibakteri. Penelitian ini bertujuan membandingkan aktivitas antibakteri ekstrak daun dan ranting tanaman ungu terhadap pertumbuhan E. coli serta menentukan konsentrasi yang efektif dalam menghambat pertumbuhan bakteri tersebut. Ekstraksi dilakukan dengan metode maserasi menggunakan pelarut etanol 96%, dengan hasil rendemen ekstrak daun sebesar 17,950% dan rendemen ekstrak ranting sebesar 8,495%. Uji antibakteri dilakukan dengan metode difusi cakram, menggunakan konsentrasi 20%, 40%, 60%, 80%, 100%, kontrol positif (+) dan negatif (-). Aktivitas antibakteri diukur berdasarkan diameter zona hambat, kemudian dianalisis secara statistik menggunakan uji Kruskal-Wallis dan Mann-Whitney. Hasil penelitian menunjukkan adanya perbedaan aktivitas antibakteri antara ekstrak daun dan ranting tanaman ungu terhadap E. coli, di mana ekstrak daun pada konsentrasi 60% memiliki rata-rata diameter zona hambat 2,448 mm, sedangkan ekstrak ranting pada konsentrasi 60% memiliki rata-rata 1,099 mm. Meskipun ekstrak daun dan ranting menunjukkan aktivitas antibakteri terhadap E. coli, daya hambat yang dihasilkan tergolong lemah sehingga tidak dapat dikategorikan efektif.
POTENSI LIMBAH TANGKAI BUAH CABAI RAWIT DAN CABAI MERAH KERITING SEBAGAI BIOINSEKTISIDA NYAMUK Aedes aegypti: POTENTIAL OF BIRD'S EYE CHILI AND RED CURLY CHILI STEM WASTE AS A BIOINSECTICIDE FOR Aedes aegypti Fadilla Amelia Riski; Dwi Susanti; Mastuti Widianingsih
JFL : Jurnal Farmasi Lampung Vol. 15 No. 1 (2026): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/665das65

Abstract

Abstract The stems of bird's eye chili (Capsicum frutescens L.) and curly red chili (Capsicum annuum L.), which are typically considered waste, actually hold compounds with potential for biological activity. Phytochemical screening has shown that stems of bird’s eye chili contain secondary metabolites such as alkaloids, phenolics, tannins, flavonoids, terpenoids, and saponins, while curly red chili stems contain alkaloids, steroids, phenolics, tannins, flavonoids, and saponins. The objective of this research to evaluate the effectiveness and determine the optimal concentration of both extracts as bioinsecticides against Aedes aegypti mosquitoes. Extraction was performed by maceration using 96% ethanol (ratio simplicial:solvent=1:10). The yield of bird’s eye chili extract was 7.45%, while curly red chili extract of 8.06%. The experiment consisted of five treatment groups with extract concentrations of 1%, 3%, and 5%; transfluthrin as a positive control; and distilled water as a negative control. Each group contained 25 Aedes aegypti mosquitoes. Mortality result indicated that both extracts had bioinsecticidal activity, although their effectiveness varied at different concentrations. The stems of bird’s eye chili extract showed the greatest effect at 5% concentration, with an LC₅₀ value of 4,177% at the 4th hour, while the curly red chili stems extract was most effective at 5% concentration, with an LC₅₀ value of 4,048% at the 5th hour. In conclusion, chili stem waste extracts demonstrate promising potential as effective and environmentally friendly botanical bioinsecticides for controlling Aedes aegypti. Keywords: Aedes aegypti, Bioinsecticide, Curly Red Chili, Chili Stem Waste
Co-Authors Dita Dwi Amanda Fadilla Amelia Riski Mastuti Widianingsih Putri Amalia