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All Journal Journal of Educational Innovation and Public Health
Lubna Nurul Mumtazah
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Dentistry Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Formulasi dan Evaluasi Sediaan Suppositoria Ibuprofen Naswa Salsabila; Lubna Nurul Mumtazah; Sayna Wahyu Ananta; Adriansyah Adriansyah; Zahra Alatas
Journal of Educational Innovation and Public Health Vol. 4 No. 2 (2026): April: Journal of Educational Innovation and Public Health
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/innovation.v4i2.9121

Abstract

Ibuprofen is an antipyretic and anti-inflammatory drug classified as Biopharmaceutics Classification System (BCS) class II, characterized by low water solubility and high permeability. Its limited solubility may reduce the dissolution rate and influence therapeutic effectiveness. This study aimed to formulate ibuprofen suppositories using cocoa butter (oleum cacao) as the suppository base through the melting method. Each suppository was prepared with a total weight of 2500 mg containing 125 mg ibuprofen, oleum cacao as the base, tween 80 as an emulsifier, and liquid paraffin as a mold lubricant. Before formulation, a displacement value test was performed to determine the exact amount of base required. The prepared suppositories were evaluated through organoleptic examination, weight uniformity, melting time, and dissolution testing. The evaluation results demonstrated that the suppositories possessed acceptable physical characteristics, uniform weight distribution, appropriate melting properties, and satisfactory dissolution behavior. Based on these findings, ibuprofen suppositories formulated with oleum cacao fulfilled pharmaceutical quality requirements in accordance with the Indonesian Pharmacopoeia standards.
Formulasi dan Evaluasi Sediaan Blush On Powder Menggunakan Ekstrak Daging Buah Naga (Hylocereus polyrhizus) Faneshia Nabil Ayushita; Aulia Jihan Kamila; Lubna Nurul Mumtazah; Nisrina Huwaida Isfaizah; Adriansyah Adriansyah
Journal of Educational Innovation and Public Health Vol. 4 No. 2 (2026): April: Journal of Educational Innovation and Public Health
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/innovation.v4i2.9149

Abstract

  Red dragon fruit contains bioactive compounds such as vitamin C, flavonoids, and polyphenols that have antioxidant potential and possess natural pigments that can be used as cosmetic colorants. This study aims to formulate and evaluate a blush-on powder preparation from dragon fruit pulp extract as an alternative natural colorant. The evaluation includes organoleptic testing, homogeneity, pH, irritation, spreadability, fineness, moisture content, and antioxidant activity. The results showed that the formulation met most of the requirements, exhibiting a pink color, a smooth texture, no odor, homogeneity, a pH of 6 suitable for the skin, no irritation, even spreadability within 4 applications, a fineness degree of 97.6%, and a moisture content of 6.91%. Antioxidant activity showed an IC₅₀ value of 0.3036 ppm (very strong), although the relative inhibition percentage was low (18.35%). Thus, dragon fruit extract has the potential as a natural ingredient in blush-on powder that provides both color and antioxidant benefits.
Co-Authors Adriansyah Adriansyah Aulia Jihan Kamila Faneshia Nabil Ayushita Naswa Salsabila Nisrina Huwaida Isfaizah Sayna Wahyu Ananta Zahra Alatas