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PENGGUNAAN PATI GANYONG (Canna edulis) SEBAGAI DISINTEGRAN PADA PEMBUATAN TABLET ASAM FOLAT DENGAN METODE CETAK LANGSUNG Azhary, Deny Puriyani; Zaelani, Diki; Lestari, Tri
JURNAL FARMASI GALENIKA Vol 4 No Edisi Khus (2017): Jurnal Farmasi Galenika Volume 4 Edisi Khusus SemNas Tanaman Obat Indon
Publisher : Sekolah Tinggi Farmasi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (336.015 KB)

Disintegran atau bahan penghancur adalah salah satu komponen penting dalam pembuatan sediaan tablet. Fungsi disintegran adalah memecah tablet sehingga zat aktif dapat dilepaskan. Disintegran yang biasa digunakan dalam formulasi sediaan tablet salah satunya adalah pati. Salah satu tumbuhan penghasil pati adalah ganyong. Ganyong  (Canna edulis) merupakan umbi yang banyak ditemukan di Indonesia dan banyak mengandung pati namun belum banyak digunakan secara optimal. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh penggunaan pati ganyong (Canna edulis) sebagai disintegran pada tablet asam folat dan dibandingkan dengan disintegran starch 1500. Tablet dibuat dengan metode cetak langsung tanpa proses granulasi. Evaluasi terhadap pati ganyong meliputi kadar air, uji swelling power, kecepatan alir, sudut diam dan kompresibilitas. Sedangkan evaluasi tablet asam folat meliputi keragaman bobot, keseragaman kandungan zat aktif, waktu hancur, disolusi, kekerasan dan friability tablet. Hasil evaluasi menunjukkan pati ganyong memiliki kompresibilitas yang tidak baik (kurang dari 20%). Sedangkan hasil evaluasi tablet menunjukkan tablet yang dibuat dengan pati ganyong memiliki waktu hancur yang sesuai persyaratan tablet yang baik, yaitu kurang dari 15 menit.

REVIEW: PROCESS OF FLUID BED GRANULATOR PARAMETERS AT THE TIME OF SCALE UP IN GRANUL PRODUCTION Diki Zaelani; Yoga Windhu Wardhana; Anis Yohana Chaerunisaa
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.836

Scaling up is one of the difficulties faced by the production process of the pharmaceutical industry. We must manufacture in higher quantities than a laboratory size with set requirements as we scale up. Understanding the crucial variables that affect the final product's specifications will aid in choosing appropriate upgrade settings. Fluidized-bed granulation is one of the most frequently used techniques to increase the scale of the pharmaceutical industry. The complex fluidized bed granulation process is influenced by several factors. The most important process variables were the intake air temperature and humidity, concentration of the binder solution, spray rate, atomizing air pressure, and air flow rate. Numerous investigations have examined the effects of large-scale fluid bed granulation. An improved fluid bed granulation technology was employed based on the relative droplet size and moisture content of the powder in the bed after the spraying cycle. These values are comparable, demonstrating that the granulation procedure can be enhanced by considering only the moisture content of the powder and relative droplet size. Keywords: fluid bed granulation, process parameters, scale up

REVIEW: PROCESS OF FLUID BED GRANULATOR PARAMETERS AT THE TIME OF SCALE UP IN GRANUL PRODUCTION Diki Zaelani; Yoga Windhu Wardhana; Anis Yohana Chaerunisaa
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.836

Scaling up is one of the difficulties faced by the production process of the pharmaceutical industry. We must manufacture in higher quantities than a laboratory size with set requirements as we scale up. Understanding the crucial variables that affect the final product's specifications will aid in choosing appropriate upgrade settings. Fluidized-bed granulation is one of the most frequently used techniques to increase the scale of the pharmaceutical industry. The complex fluidized bed granulation process is influenced by several factors. The most important process variables were the intake air temperature and humidity, concentration of the binder solution, spray rate, atomizing air pressure, and air flow rate. Numerous investigations have examined the effects of large-scale fluid bed granulation. An improved fluid bed granulation technology was employed based on the relative droplet size and moisture content of the powder in the bed after the spraying cycle. These values are comparable, demonstrating that the granulation procedure can be enhanced by considering only the moisture content of the powder and relative droplet size. Keywords: fluid bed granulation, process parameters, scale up

PELATIHAN PEMBUATAN TEH HERBAL UNTUK MENINGKATKAN KUALITAS KESEHATAN MASYARAKAT DI DESA CIBIRU WETAN Istiqomah, Aulia Nurfazri; Roni, Asep; Budiana, Wempi; Lisni, Ida; Zaelani, Diki; Sutrisno, Entris
Jurnal Pengabdian Masyarakat (Jupemas) Vol 5, No 1 (2024)
Publisher : Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jupemas.v5i1.1285

The current condition of Indonesia can be said to be facing a triple burden. Based on research results from the Central Statistics Agency, the percentage of the population, especially the population of West Java, who had health complaints during the last month in 2022 showed an increase compared to the previous year (2021), this is of course related to the quality of public health. The problem currently faced by partners is the lack of information and education regarding the processing of nutritious plants. So far, the crops obtained have been used in simple ways, eaten directly as fresh vegetables or processed as food.This time the community service program was carried out in Cibiru Wetan Village, Cileunyi District, Bandung Regency. Activities include providing education regarding efficacious herbal plants and tutorials on making herbal tea as an effort to improve the quality of health.From the results of implementing this community service activity, the residents of Cibiru Wetan Village, Cileunyi District, Bandung Regency have understood the ingredients that can be used in an effort to improve the quality of health and one way of processing them

PENGGUNAAN PATI GANYONG (Canna edulis) SEBAGAI DISINTEGRAN PADA PEMBUATAN TABLET ASAM FOLAT DENGAN METODE CETAK LANGSUNG Deny Puriyani Azhary; Diki Zaelani; Tri Lestari
JURNAL FARMASI GALENIKA Vol 4 No Edisi Khus (2017): Jurnal Farmasi Galenika Volume 4 Edisi Khusus SemNas Tanaman Obat Indone
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Disintegran atau bahan penghancur adalah salah satu komponen penting dalam pembuatan sediaan tablet. Fungsi disintegran adalah memecah tablet sehingga zat aktif dapat dilepaskan. Disintegran yang biasa digunakan dalam formulasi sediaan tablet salah satunya adalah pati. Salah satu tumbuhan penghasil pati adalah ganyong. Ganyong (Canna edulis) merupakan umbi yang banyak ditemukan di Indonesia dan banyak mengandung pati namun belum banyak digunakan secara optimal. Penelitian ini bertujuan untuk mengetahui bagaimana pengaruh penggunaan pati ganyong (Canna edulis) sebagai disintegran pada tablet asam folat dan dibandingkan dengan disintegran starch 1500. Tablet dibuat dengan metode cetak langsung tanpa proses granulasi. Evaluasi terhadap pati ganyong meliputi kadar air, uji swelling power, kecepatan alir, sudut diam dan kompresibilitas. Sedangkan evaluasi tablet asam folat meliputi keragaman bobot, keseragaman kandungan zat aktif, waktu hancur, disolusi, kekerasan dan friability tablet. Hasil evaluasi menunjukkan pati ganyong memiliki kompresibilitas yang tidak baik (kurang dari 20%). Sedangkan hasil evaluasi tablet menunjukkan tablet yang dibuat dengan pati ganyong memiliki waktu hancur yang sesuai persyaratan tablet yang baik, yaitu kurang dari 15 menit.

Pengembangan Formula Granul Effervescent Ekstrak Kulit Melinjo (Gnetum gnemon) Sebagai Antioksidan Alami Sagita, Novaliana Devianti; Sani, Afifah Rusyda; Supriadi, Dadih; Sutoro, Meylani; Zaelani, Diki; Pratama, Reza
Majalah Farmasetika Vol 10, No 3 (2025)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v10i2.62308

Fokus pada kesehatan dan pencegahan penyakit telah mendorong pengembangan produk berbahan dasar alami dengan aktivitas antioksidan. Kulit buah melinjo (Gnetum gnemon) mengandung senyawa antioksidan seperti alkaloid, flavonoid, dan saponin, tetapi pemanfaatannya masih minim. Mengembangkan dan mengevaluasi formulasi granul effervescent ekstrak kulit melinjo, serta mengukur aktivitas antioksidannya. Penelitian eksperimental ini menggunakan metode granulasi basah. Tahapan penelitian meliputi skrining fitokimia, formulasi, evaluasi sifat fisik granul, dan uji aktivitas antioksidan menggunakan metode DPPH. Evaluasi mencakup parameter seperti organoleptik, waktu larut, kadar air, laju alir, sudut istirahat, kompresibilitas, pH, tinggi buih, dan volume sedimentasi. Skrining fitokimia menunjukkan adanya alkaloid, flavonoid, dan saponin pada ekstrak kulit melinjo. Semua formula granul memiliki sifat fisik yang memenuhi standar dengan laju alir 4-10 gram/detik), sudut istirahat (20°<α<40°), indeks kompresibilitas (<20%), serta dengan waktu larut rata-rata kurang dari 5 menit dan stabilitas suspensi yang baik dengan pH 5-7. Nilai IC50 menunjukkan aktivitas antioksidan dengan rentang 35,324–40,321 µg/mL, termasuk kategori sangat kuat. Granul effervescent berbasis ekstrak kulit melinjo memiliki potensi sebagai minuman kesehatan dengan aktivitas antioksidan yang baik. Ditunjukkan oleh sifat fisik yang sesuai dan aktivitas antioksidan yang kuat dan F2 memiliki aktivitas antioksidan IC50 paling tinggi sebesar 40,321 ± 0,324 µg/mL dan termasuk kategori sangat kuat.

Uji Kelarutan Ramipril dengan Koformer Nicotinamide M. Ramadhan Saputro; Muhamad Reza Pahlevi; Diki Zaelani; Dean Al-Ayubbi; Siti Hanif
An-Najat Vol. 3 No. 3 (2025): Agustus : An-Najat : Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v3i3.2823

Ramipril (RMP) is one of the drugs that has antihypertensive activity. The drawback of the active substance Ramipril is that it is difficult to dissolve, and is classified in Class II in the Biopharmaceutical Classification System. So it needs to be modified with a cocrystal technique to increase solubility without having to change the activity of the active substance. The coformer used to make the cocrystal is nicotinamide. The purpose of this study was to increase the solubility of Ramipril with Nicotinamide coformer. The method in making this cocrystal is Solvent Drop Grinding (SDG) with a ratio of Ramipril: Nicotinamide (1: 2 and 1: 4) using methanol solvent. Then the cocrystal and pure Ramipril will be subjected to characterization tests with FTIR and solubility tests with UV spectrophotometry at a wavelength of 206 nm. The results of the characterization with FTIR prove that a hydrogen bond is formed between Ramipril-Nicotinamide. Then for solubility in aquadest, RN cocrystal 1:2 and 1:4 have higher solubility which is 5.11 mg/mL and 6.71 mg/mL compared to pure Ramipril which has a solubility of 1.69 mg/mL. The conclusion of this study is that RN cocrystal (1:2 and 1:4) has higher solubility compared to pure Ramipril.

Uji Aktivitas Antioksidan Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) Yang Diformulasikan Kedalam Sediaan Masker Gel Zaelani, Diki; Pratama, Reza; Japar Sodik, Jajang; Hilda Restu, Afria
JURNAL FARMASI GALENIKA Vol 11 No 1 (2024): Jurnal Farmasi Galenika Vol 11 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i1.330

This study utilizes the Phaleria macrocarpa fruit (Phaleria macrocarpa (Scheff.) as an active ingredient in gel mask formulation due to its widespread use as a medicinal plant and its antioxidant properties that can inhibit free radicals. The research began with the collection of the fruit from the experimental garden in Lembang-Bandung, identified as Phaleria macrocarpa (Scheff.) Boerl. Extraction was conducted using the maceration method with 96% ethanol for 3x24 hours. Phytochemical screening results indicated the presence of alkaloids, flavonoids, tannins, triterpenoids, and steroids. Antioxidant activity of the gel masks was tested using the DPPH immersion method, resulting in IC50 values of 60.18 ppm, 57.18 ppm, and 54.82 ppm for three different formulations. The pure extract had an IC50 of 45.11 ppm. The gel masks remained stable despite changes in pH and viscosity, with formulation 2 being the most preferred according to the hedonic test. In conclusion, the Phaleria macrocarpa gel mask exhibits effective antioxidant activity and good stability.

Development and Evaluation of Microcapsules Containing Combined Extracts of Bay, Cherry, and Green Betel Leaves as Natural Antioxidants Pratama, Reza; Budiana, Wempi; Zaelani, Diki; Asnawi, Aiyi
Sciences of Pharmacy Volume 4 Issue 4
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0404493

Bay leaf (Syzygium polyanthum), cherry leaf (Muntingia calabura), and green betel leaf (Piper betle) contain phenolic and flavonoid compounds with antioxidant potential, but their utilization is limited by physicochemical instability. This study aimed to develop microcapsules containing a combined extract of these three leaves and to evaluate their physicochemical properties and in vitro antioxidant activity as an initial formulation feasibility study. Each extract was prepared by maceration using 96% ethanol, yielding 11.42–15.86%, and combined in a 1:1:1 (w/w/w) ratio prior to microencapsulation. Microcapsules were produced using a fluidized bed dryer with lactose as the core material and polyvinyl alcohol (PVA) as the coating polymer. Physicochemical characterization included moisture content, flow rate, angle of repose, compressibility index, dissolution time, particle size, and surface morphology. Antioxidant activity was assessed using DPPH and CUPRAC assays, with IC₅₀ values calculated from triplicate measurements. The coating process increased mean particle size from 636.2 µm to 728.0 µm and prolonged dissolution time from 2.14 to 3.55 minutes, indicating coating layer formation. Among the individual extracts, cherry leaf extract showed the strongest antioxidant activity. The microcapsules exhibited antioxidant activity within the same order of magnitude as the combined extract under initial, non-stressed testing conditions. These results demonstrate the feasibility of formulating combined plant extracts into microcapsules with acceptable physical properties, while further stability and comparative studies are required to support antioxidant preservation and potential applications.

Formulation, Physicochemical Characterization, and Antibacterial Activity of Ethanolic Rosa spp. Extract Topical Gel Against Cutibacterium acnes Diki Zaelani; Abdul Mulki Irfani; Merylance Stefany Sanggo; Jajang Japar Sodik; Reza Pratama
Jurnal Jamu Indonesia Vol. 11 No. 2 (2026): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v11i2.470

his study evaluated a topical gel containing ethanolic red rose (Rosa spp.) extract against Cutibacterium acnes. Phytochemical screening identified alkaloids, flavonoids, tannins, and anthocyanins. Five gel formulas were developed using 0.25–1.25% Carbopol 940. All formulations showed pseudoplastic flow characteristics. Measured pH values ranged from 7.02 to 7.08, indicating a need for adjustment to meet physiological skin pH (4.5–5.5). Formulas with 0.5% and 0.75% Carbopol (F2 and F3) exhibited the most balanced viscosity, spreadability, and adhesiveness. In vitro antibacterialtests via disc diffusion showed inhibition zones of 14–15 mm against C. acnes. These results indicate that the extract can be formulated into a stable gel while maintaining antibacterial activity. Future optimization should focus on pH correction and long-term stability to ensure dermatological safety.

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