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All Journal Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Medical Sains : Jurnal Ilmiah Kefarmasian Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Farmasi Galenika Sasambo: Jurnal Abdimas (Journal of Community Service)
Jajang Japar Sodik
Faculty Of Pharmacy, Universitas Bhakti Kencana
Humanities Computer Science & IT Education Health Professions Medicine & Pharmacology Nursing Public Health Social Sciences Other

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REVIEW ARTIKEL: ANALISIS MOLECULAR DOCKING SENYAWA GOLONGAN FLAVONOID SEBAGAI ANTIBAKTERI TERHADAP RESEPTOR PBP 2A BAKTERI MRSA: ARTICLE REVIEW: MOLECULAR DOCKING ANALYSIS OF FLAVONOID COMPOUNDS AS ANTIBACTERIALS AGAINST PBP 2A RECEPTORS OF MRSA BACTERIA Jajang Japar Sodik; Deden Indra Dinata
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.736

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA), bakteri yang resisten terhadap antibiotik b-laktam seperti methicillin, merupakan masalah klinis yang terus-menerus mempengaruhi seluruh dunia. Resistensi terjadi akibat adanya modifikasi struktural protein pengikat penisilin (PBP)2a bakteri MRSA. Flavonoid adalah salah satu senyawa aktif terpenting yang secara alami terdapat pada tanaman. Beberapa flavonoid telah terbukti memiliki sifat antibakteri pada penelitian sebelumnya. Penambatan molekul (Molecular Docking) merupakan salah satu metode in silico (virtual) berbasis struktur yang paling sering digunakan dan paling sederhana. Tujuan dari review jurnal untuk mengetahui senyawa turunan flavonoid pada tanaman obat yang berpotensi untuk dikembangkan sebagai pengobatan antibakteri terhadap  bakteri MRSA berdasarkan dari beberapa studi secara in-silico. Metode pencarian jurnal dilakukan melalui website https://scholar.google.co.id/ dan Pubmed dengan menggunakan kata kunci Molecular Docking Flavonoid Methicillin Resistant Staphylococcus aureus. Hasil yang didapat adalah dari 31 senyawa aktif turunan flavonoid  yang berpotensi menghambat reseptor PBP2a bakteri MRSA. Pada PDB ID IMWT didapatkan senyawa terbaik Diferulic acid memiliki nilai binding affinity sebesar  -102.4,  pada PDB ID 1VQQ didapatkan senyawa terbaik Hesperidin memiliki nilai binding affinity sebesar -9.2 dan pada PDB ID 4DKI didapatkan senyawa terbaik Quercetin 3-O-rutinoside  memiliki nilai binding affinity sebesar -91.56. Kata kunci : Molecular Docking , Methicillin-resistant Staphylococcus aureus (MRSA), Flavonoid.
REVIEW ARTIKEL: ANALISIS MOLECULAR DOCKING SENYAWA GOLONGAN FLAVONOID SEBAGAI ANTIBAKTERI TERHADAP RESEPTOR PBP 2A BAKTERI MRSA: ARTICLE REVIEW: MOLECULAR DOCKING ANALYSIS OF FLAVONOID COMPOUNDS AS ANTIBACTERIALS AGAINST PBP 2A RECEPTORS OF MRSA BACTERIA Jajang Japar Sodik; Deden Indra Dinata
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.736

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA), bakteri yang resisten terhadap antibiotik b-laktam seperti methicillin, merupakan masalah klinis yang terus-menerus mempengaruhi seluruh dunia. Resistensi terjadi akibat adanya modifikasi struktural protein pengikat penisilin (PBP)2a bakteri MRSA. Flavonoid adalah salah satu senyawa aktif terpenting yang secara alami terdapat pada tanaman. Beberapa flavonoid telah terbukti memiliki sifat antibakteri pada penelitian sebelumnya. Penambatan molekul (Molecular Docking) merupakan salah satu metode in silico (virtual) berbasis struktur yang paling sering digunakan dan paling sederhana. Tujuan dari review jurnal untuk mengetahui senyawa turunan flavonoid pada tanaman obat yang berpotensi untuk dikembangkan sebagai pengobatan antibakteri terhadap  bakteri MRSA berdasarkan dari beberapa studi secara in-silico. Metode pencarian jurnal dilakukan melalui website https://scholar.google.co.id/ dan Pubmed dengan menggunakan kata kunci Molecular Docking Flavonoid Methicillin Resistant Staphylococcus aureus. Hasil yang didapat adalah dari 31 senyawa aktif turunan flavonoid  yang berpotensi menghambat reseptor PBP2a bakteri MRSA. Pada PDB ID IMWT didapatkan senyawa terbaik Diferulic acid memiliki nilai binding affinity sebesar  -102.4,  pada PDB ID 1VQQ didapatkan senyawa terbaik Hesperidin memiliki nilai binding affinity sebesar -9.2 dan pada PDB ID 4DKI didapatkan senyawa terbaik Quercetin 3-O-rutinoside  memiliki nilai binding affinity sebesar -91.56. Kata kunci : Molecular Docking , Methicillin-resistant Staphylococcus aureus (MRSA), Flavonoid.
COMPARISON OF ANALYSIS METHODS FOR CURCUMIN DETERMINATION: A LITERATURE REVIEW Jajang Japar Sodik; Deden Indra Dinata; R. Herni Kusriani; Garnadi Jafar
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 4 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i4.850

Abstract

Curcuminoids such as curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin (BDMC) are the major bioactive components found in Curcuma species, including turmeric (Curcuma longa L.). Curcumin is a polyphenol that is used as an antioxidant. Various analytical methods have been developed for the detection of curcumin, each with its advantages and limitations. Selection of an appropriate analytical method is crucial for obtaining accurate results. Although critical reviews on the chemical, biological, and pharmacological properties of curcumin are widely available, reviews specifically focusing on the different analytical methods for curcumin are limited. This review article aims to provide an overview of several analytical methods for the determination of curcumin. This is expected to encourage readers to choose a suitable analytical method for their specific needs. The articles used in this review were sourced from international English-language publications obtained from Science Direct, PubMed, and Google Scholar. The search was performed using keywords such as "Instrumental analysis of curcumin" and "Analytical techniques for curcumin analysis." The results reveal that spectrophotometric methods are simple techniques used to estimate curcumin content; however, their utility is limited to cases where the concentration of each curcuminoid is not a critical quality parameter. Accurate quantification and detection of trace amounts of curcuminoids and metabolites require the use of chromatographic separation methods combined with mass spectrometry detection (LC-MS/MS) because of their high accuracy, reproducibility, and sensitivity with low limits of detection (LOD) and lower limits of quantification (LLOQ). Keywords: Analytical methods, Curcumin, Determination
REVIEW: THE POTENTIAL OF HERBAL PLANTS AS ANTI-ALOPECIA MEDICINES Arif Rubianto; Garnadi Jafar; Deden Indra Dinata; Jajang Japar Sodik
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1204

Abstract

Hair loss, or alopecia, is a common dermatological condition that affects up to 2% of the world's population. It is often caused by genetic factors, such as male or female pattern baldness, but can also be attributed to various environmental factors, an imbalanced diet, or chronic illnesses. While hair loss is not life-threatening, it can lead to significant anxiety, depression, and other psychological issues, ultimately affecting one's quality of life. Various treatments for baldness, including synthetic drugs like minoxidil and finasteride, or herbal remedies, have been approved by the Food and Drug Administration. Although synthetic drugs are effective, they may come with potential side effects. Natural remedies have been proposed as a viable option for treating baldness because many chronic disorders can lead to alopecia. Therefore, this review focuses on identifying efficient alternative treatment agents with limited side effects. Specifically, it considers medicinal plants as potential healing agents for treating baldness. To gather relevant information for this study, several databases were searched, including Scopus, PubMed, and Google Scholar. Comprehensive searches were conducted using various search terms, such as "baldness," "alopecia," "natural remedies for baldness," "herbal treatment for baldness," and others, to extract relevant scientific articles. Many medicinal plants and natural compounds have shown potential for reducing baldness, thanks to their anti-inflammatory and antioxidant properties. According to existing literature, extracts of medicinal plants and formulations derived from plants, such as Eclipta alba (L.) Hassk, Arctium lappa L., Centella asiatica L., Morinda citrifolia, Acorus calamus var. angustatus, Alpinia zerumbet, ...
Uji Aktivitas Antioksidan Ekstrak Buah Mahkota Dewa (Phaleria macrocarpa (Scheff.) Boerl.) Yang Diformulasikan Kedalam Sediaan Masker Gel Diki Zaelani; Reza Pratama; Jajang Japar Sodik; Afria Hilda Restu
JURNAL FARMASI GALENIKA Vol 11 No 1 (2024): Jurnal Farmasi Galenika Vol 11 No 1
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v11i1.330

Abstract

This study utilizes the Phaleria macrocarpa fruit (Phaleria macrocarpa (Scheff.) as an active ingredient in gel mask formulation due to its widespread use as a medicinal plant and its antioxidant properties that can inhibit free radicals. The research began with the collection of the fruit from the experimental garden in Lembang-Bandung, identified as Phaleria macrocarpa (Scheff.) Boerl. Extraction was conducted using the maceration method with 96% ethanol for 3x24 hours. Phytochemical screening results indicated the presence of alkaloids, flavonoids, tannins, triterpenoids, and steroids. Antioxidant activity of the gel masks was tested using the DPPH immersion method, resulting in IC50 values of 60.18 ppm, 57.18 ppm, and 54.82 ppm for three different formulations. The pure extract had an IC50 of 45.11 ppm. The gel masks remained stable despite changes in pH and viscosity, with formulation 2 being the most preferred according to the hedonic test. In conclusion, the Phaleria macrocarpa gel mask exhibits effective antioxidant activity and good stability.
Edukasi Kesehatan dan Pemanfaatan Herbal untuk Pencegahan dan Pengelolaan Hipertensi di Kabupaten Bandung Patonah Patonah; Aris Suhardiman; Lia Marliani; Purwaniati Purwaniati; Mamay M Sobandi; Jajang Japar Sodik
Sasambo: Jurnal Abdimas (Journal of Community Service) Vol. 6 No. 4 (2024): November
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/sasambo.v6i4.2128

Abstract

Program pengabdian masyarakat ini berfokus pada edukasi kesehatan dan pemanfaatan herbal untuk pencegahan dan pengelolaan hipertensi di Kabupaten Bandung. Program ini dirancang untuk mengatasi tingginya prevalensi hipertensi melalui pendekatan promotif dan preventif. Kegiatan edukasi meliputi seminar kesehatan interaktif, demonstrasi praktis penggunaan herbal, serta skrining kesehatan yang mencakup pengukuran tekanan darah, glukosa, kolesterol, dan asam urat. Hasilnya menunjukkan peningkatan signifikan dalam pengetahuan masyarakat, di mana persentase peserta dengan pemahaman memadai tentang hipertensi meningkat dari 19% menjadi 72%. Selain itu, peserta mulai menerapkan perilaku hidup sehat, seperti mengurangi konsumsi garam dan meningkatkan aktivitas fisik. Pengenalan herbal seperti jahe, kunyit, dan seledri memberikan alternatif strategi pengendalian tekanan darah yang mengintegrasikan kearifan lokal dengan ilmu pengetahuan modern. Inisiatif ini menunjukkan efektivitas intervensi berbasis komunitas secara holistik dalam meningkatkan hasil kesehatan masyarakat dan pentingnya program edukasi kesehatan yang berkelanjutan. Health Education and Herbal Utilization for Hypertension Prevention and Management in Bandung Regency This community service program focused on health education and herbal utilization for the prevention and management of hypertension in Bandung Regency. The program was designed to address the high prevalence of hypertension through promotive and preventive approaches. Activities included interactive health seminars, practical demonstrations on herbal utilization, and health screenings for blood pressure, glucose, cholesterol, and uric acid levels. The results showed a significant improvement in community knowledge, with the percentage of participants with adequate understanding of hypertension increasing from 19% to 72%. Additionally, participants adopted healthier behaviors, such as reducing salt intake and increasing physical activity. The introduction of herbal remedies, including ginger, turmeric, and celery, offered alternative strategies for blood pressure control, integrating local wisdom with modern science. This initiative demonstrated the effectiveness of holistic community-based interventions in improving public health outcomes and underscored the importance of sustainable health education programs.
Hipertensi dalam Kehamilan dan Risiko Stunting Intervensi Sosialisasi Kesehatan untuk Mencegah Stunting di Masa Depan Muhamad Reza Pahlevi; Dadang Juanda; Nita Selifiana; Ika Kurnia Sukmawati; Widhya Aligita; Deni Iskandar; Jajang Japar Sodik
Sasambo: Jurnal Abdimas (Journal of Community Service) Vol. 6 No. 4 (2024): November
Publisher : Lembaga Penelitian dan Pemberdayaan Masyarakat (LITPAM)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36312/sasambo.v6i4.2231

Abstract

Pengabdian masyarakat ini bertujuan untuk meningkatkan kesadaran mengenai hubungan antara hipertensi pada kehamilan dan risiko stunting melalui intervensi edukasi kesehatan. Dengan pendekatan kuasi-eksperimen, program ini melibatkan evaluasi pre-test dan post-test dengan 30 wanita dewasa di Desa Serang Mekar, Kecamatan Ciparay, Kabupaten Bandung. Partisipan dipilih secara purposif berdasarkan persetujuan dan kondisi kesehatan. Hasil menunjukkan peningkatan signifikan dalam pengetahuan, dengan pemahaman mengenai kaitan hipertensi dan stunting naik dari 43,3% pada pre-test menjadi 100% pada post-test. Pengukuran tekanan darah sebelum dan sesudah sesi edukasi juga menunjukkan perbaikan, yang mengindikasikan dampak positif program edukasi terhadap kesadaran dan praktik kesehatan. Pengabdian ini merekomendasikan edukasi kesehatan berkelanjutan yang fokus pada pengelolaan hipertensi selama kehamilan, terutama di daerah pedesaan. Inisiatif berbasis komunitas dengan melibatkan kader kesehatan lokal dapat meningkatkan keberlanjutan program dan membantu menurunkan prevalensi stunting di Indonesia. Hypertension in Pregnancy and the Risk of Stunting: Health Education Intervention to Prevent Future Stunting This community service aimed to raise awareness about the link between hypertension in pregnancy and the risk of stunting through health education interventions. Using a quasi-experimental approach, the program involved pre-test and post-test evaluations with 30 adult women in Desa Serang Mekar, Kecamatan Ciparay, Kabupaten Bandung. Participants were purposively selected based on consent and health status.Results showed a significant increase in participants’ knowledge, with recognition of the link between hypertension and stunting rising from 43.3% in the pre-test to 100% in the post-test. Blood pressure measurements before and after the sessions also improved, indicating a positive impact of the education program on health awareness and practices. This community service recommends ongoing health education focused on managing hypertension during pregnancy, particularly in rural areas. Community-based initiatives involving local health cadres can enhance the program’s sustainability and help reduce stunting prevalence in Indonesia
Tingkat Kepuasan Pasien terhadap Kualitas Pelayanan Obat di Apotek Rio Mamay Maulana Sobandi; Akhamad Priyadi; Jajang Japar Sodik
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 5 (2024): September : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i5.647

Abstract

Patient satisfaction with pharmacy services is a crucial indicator in assessing the quality of healthcare services provided. Patient satisfaction is influenced by the comparison between perceived performance and expectations. If service performance exceeds expectations, patients will be highly satisfied. This study aims to measure the level of patient satisfaction with the quality of drug services at Rio Pharmacy. This descriptive study uses primary data obtained through questionnaires completed by respondents. The results show that all five dimensions of service quality received positive ratings. The Responsiveness dimension has the most significant influence with a score of 56, followed by Reliability, Assurance, and Empathy, each with a score of 52, and Tangible with a score of 47. Overall, patients are satisfied with the quality of drug services at Rio Pharmacy.
Utilization of TOGA to Reduce the Risk of Hypertension in Cibiru Wetan Village Jajang Japar Sodik; Fenti Fatmawati; Mia Nisrina Anbar Fatin; Wempi Budiana
Warta Pengabdian Andalas Vol 32 No 1 (2025)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.32.1.55-60.2025

Abstract

Community service activities in Cibiru Wetan Village, Bandung Regency have been carried out by lecturers and students of the Faculty of Pharmacy, Bhakti Kencana University (BKU) with partners, namely PKK Cibiru Wetan and Cibiru Wetan Health Center. Activities carried out in November include health screening (blood pressure, blood sugar, uric acid and total cholesterol checks), education on hypertension and the benefits of TOGA, training in processing medicinal plants such as ginger, Kaempferia galanga, and Curcuma into ready-to-consume herbal products, distribution of booklets on practical guidelines for the use of TOGA. This activity involves BKU lecturers from various expertise groups such as Pharmacology & Clinical Pharmacy; Pharmacy and Pharmaceutical Technology; General Pharmacy and Pharmacists; Pharmaceutical Biology.
Co-Authors Afria Hilda Restu Akhamad Priyadi Arif Rubianto Aris Suhardiman Dadang Juanda Deden Indra Dinata Deni Iskandar Fenti Fatmawati Garnadi Jafar, Garnadi Hasimun, Patonah Ika Kurnia Sukmawati Lia Marliani Mamay M Sobandi Mamay Maulana Sobandi Mia Nisrina Anbar Fatin Muhamad Reza Pahlevi Nita Selifiana Purwaniati, Purwaniati Reza Pratama Wempi Budiana Widhya Aligita Zaelani, Diki