Article Per Year (5 Year)
p-Index From 2021 - 2026
0.408
P-Index
This Author published in this journals
All Journal Jurnal Penelitian Farmasi Indonesia JURNAL FARMASIMED (JFM)
Fathnur Sani Kasmadi
Program Studi Farmasi, Fakultas Kedokteran dan Ilmu Kesehatan, Universitas Jambi
Medicine & Pharmacology

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
POTENSI AKTIVITAS ANTIOKSIDAN VARIASI EKSTRAK ETANOL DAUN KAYU MANIS (Cinnamomum burmannii) DARI DAERAH MUARO LABUH DENGAN METODE DPPH Fathnur Sani Kasmadi; Bima Arya Nugraha; M.Rifqi Efendi; Entang Komalasari; Tri Nadia Putri
Jurnal Penelitian Farmasi Indonesia Vol 14 No 2 (2025): JPFI
Publisher : Pusat Penelitian dan Pengabdian Masyarakat (P3M) Sekolah Tinggi Ilmu Farmasi Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51887/jpfi.v14i2.1993

Abstract

Antioksidan berfungsi sebagai penstabil dengan cara memberikan elektron yang mampu menghambat reaksi berantai radikal bebas. Penelitian sebelumnya menunjukkan bahwa variasi pelarut etanol yang digunakan dan lokasi tumbuh suatu tanaman mempengaruhi aktivitas antioksidan dari tanaman tersebut. Penelitian ini bertujuan untuk identifikasi aktivitas antioksidan dari variasi ekstrak etanol daun kayu manis (25%, 50% dan 100%). Metode yang digunakan untuk pengujian aktivitas antioksidan adalah metode DPPH dengan kontrol positif yang digunakan adalah vitamin C. Hasil menunjukkan adanya perbedaan yang signifikan antar kelompok. Dimana ekstrak etanol 25% memiliki antivitas antioksidan yang sangat kuat (IC50 = 38,24 ± 0,67 ppm), sedangkan ekstrak etanol 50% (IC50 = 123,17 ± 0,83 ppm) dan 100% (IC50 = 136,18 ± 2,51 ppm) dari daun kayu manis memiliki aktivitas sedang. Antioxidants function as stabilizers by providing electrons that can inhibit free radical chain reactions. Previous studies have shown that variations in ethanol solvents used and the location where a plant grows affect the antioxidant activity of the plant. This study aims to identify the antioxidant activity of variations in cinnamon leaf ethanol extract (25%, 50% and 100%). The method used to test antioxidant activity is the DPPH method with the positive control used being vitamin C. The results showed significant differences between groups. Where 25% ethanol extract has very strong antioxidant activity (IC50 = 38.24 ± 0.67 ppm), while 50% ethanol extract (IC50 = 123.17 ± 0.83 ppm) and 100% (IC50 = 136.18 ± 2.51 ppm) from cinnamon leaves have moderate activity.
Test of 25% Ethanol Extract of Betel Nut as a Burn Wound Healing Agent in Male White Mice Muhammad Farhan; Fathnur Sani Kasmadi; Humaryanto Humaryanto; Erni Kusdiyah; Huntari Harahap
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/adcwgh75

Abstract

Burns are a serious injury that requires effective therapy to accelerate the healing process. This study aims to evaluate the effectiveness of 25% ethanol extract of areca nut (Areca catechu L.) on healing second-degree burns in male white rats (Rattus norvegicus). The extract was obtained through a maceration method and characterized for its secondary metabolite content. A total of 25 rats were divided into five groups: a negative control (Vaseline flavum), a positive control (Bioplacenton®), and three treatment groups with extract concentrations of 2%, 4%, and 6%. The topical preparation was applied daily for 21 days, then clinical observations were carried out in the form of wound diameter measurements and histopathological analysis (re-epithelialization, collagenization, angiogenesis, and the number of fibroblasts). Phytochemical results showed that the extract contained flavonoids, alkaloids, tannins, phenols, and steroids. Clinically, the treatment group with a concentration of 6% showed the greatest reduction in wound diameter (56.6%) compared to the low concentration extract group and the negative control, although not exceeding the positive control. Histological analysis showed more even re-epithelialization, increased fibroblasts, and a more organized collagen fiber arrangement in the 6% group. These findings indicate that a 25% ethanol extract of areca nut has the potential to accelerate burn wound healing through antioxidant, antimicrobial, astringent, and anti-inflammatory mechanisms, although its effectiveness is still below standard therapy. Further research is needed to optimize the dosage and formulation for its development as an affordable, natural-based alternative phytotherapy.
Co-Authors Bima Arya Nugraha Entang Komalasari Erni Kusdiyah Humaryanto Humaryanto Huntari Harahap M.Rifqi Efendi Muhammad Farhan Tri Nadia Putri