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All Journal Jurnal Farmasi Higea Jurnal Kefarmasian Indonesia
Ifora, Ifora
STIFARM Padang
Chemistry Medicine & Pharmacology

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Journal : Jurnal Farmasi Higea

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Efek Antikolesterol Ekstrak Etanol Buah Kundua (Benincasa Hispida (Thunb.) Cogn.) pada Mencit Putih Jantan Ifora, Ifora; Eriadi, Aried; Kardela, Widya; Mandala, Yoga Febrian
Jurnal Farmasi Higea Vol 10, No 2 (2018)
Publisher : STIFARM Padang

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Abstract

Hiperkolesterolemia merupakan suatu keadaan saat kadar kolesterol tinggi didalam darah. Penelitian ini bertujuan untuk melihat pengaruh ekstrak etanol buah kundua (Benincasa hispida (Thunb.) Cogn.) terhadap kadar kolesterol total, LDL, trigliserida, VLDL dan HDL pada mencit putih jantan. Penginduksi peningkat kolesterol yang digunakan berupa makanan lemak tinggi dan prophlythiourassil secara peroral selama 14 hari. Kemudian dilanjutkan penambahan pemberian ekstrak secara peroral satu kali sehari selama 14 hari dengan dosis 150 mg/kg BB; 300 mg/kg BB dan 600 mg/kg BB. Parameter yang diamati adalah kadar kolesterol total, LDL, trigliserida, VLDL dan HDL. Pengukuran dilakukan pada hari ke-29 menggunakan fotometer v5­+ 5010. Data hasil penelitian ini dianalisis dengan ANOVA satu arah. Dari hasilpenelitian dapat disimpulkan bahwa, pemberian ekstrak etanol buah kundua (Benincasa hispida (Thunb.) Cogn.) tidak dapat mempengaruhi secara signifikan penurunan kadar kolesterol total, LDL, trigliserida, VLDL  dan peningkatan kadar HDL pada mencit putih jantan hiperkolesterolemia.Kata Kunci : Ekstrak etanol; Benincasa hispida (Thunb.) Cogn.; Hiperkolesterolemia; Prophylthiourassil
Uji Efek Teratogen Ekstrak Etanol Daun Sirsak (Annona muricata L) Terhadap Fetus Mencit Putih Ifora, Ifora; Suhatri, Suhatri; Yolandha, Suzie
Jurnal Farmasi Higea Vol 8, No 1 (2016)
Publisher : STIFARM Padang

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Abstract

Research on test teratogenic effects of ethanol  extract of leaves of the soursop (Annona muricata L.) have been conducted on white mice fetus. Animal experiments are grouped into  4 group consisting of Group I as a negative control only granted suspension of Na CMC 0.5%, Group II, Group III and Group IV granted soursop leaf ethanol extract at a dose of 250 mg / kg, 500 mg / kg, and 1000 mg / kg once daily from day 6 to day 15 of pregnancy. The 18th day of pregnancy mice were dissected. Results of the study at a dose of 250 mg / kg, a dose of 500 mg / kg, a dose of 1000 mg / kg give teratogen effects. A dose of 250 mg / kg, a dose of 500 mg / kg give teratogen effect with the discovery of skeletal abnormalities. A dose of 1000 mg / kg give teratogen effect with the discovery of late growth. Results showed that the ethanol extract of the leaves of the soursop affect weight loss parent mice were significantly (p <0.05) when compared to the negative control. The quantity of fetuses decreased significantly (p <0.05) when compared to the negative control. Fetal body weight showed a significant effect (p <0.05) when compared to the negative control.
Co-Authors Eriadi, Aried Mandala, Yoga Febrian Sintia, Bella Srangenge, Yoneta Suhatri Suhatri Widya Kardela Yolandha, Suzie