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All Journal Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Jurnal Kefarmasian Indonesia
Srangenge, Yoneta
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Chemistry Computer Science & IT Medicine & Pharmacology Social Sciences Other

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Pengaruh Penghambatan Enzim Siklooksigenase-2 dan Aktivitas Antiinflamasi dari Ekstrak Daun Ketumbar (Coriandrum sativum L.) Ifora, Ifora; Sintia, Bella; Srangenge, Yoneta
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 1, FEBRUARI 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i1.3487

Abstract

Inflammation is a normal protective response to tissue damage that mediated by Cyclooxygenase-2 (COX-2) enzyme. The enhancement incidence and impact of inflammatory diseases have encouraged the search for new pharmacological strategies to overcome the problem. Ketumbar (Coriandrumsativum L.) has been traditionally used as an anti-inflammatory and antioxidant, thus giving chance for anti-inflammatory studies. This study aims to determine the ethanol extract of Ketumbar (Coriandrumsativum L.) leaves anti-inflammatory activity and inhibitory effect on COX-2 enzyme. This study uses male wistar rats with 180–220 g body weights. The rats is divided into six groups by the dose of 125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW; positive control (Carrageenan 1%); negative control (Na. CMC 0,5%); and comparative group (Celecoxib 9 mg/kg BW). Determining the anti-inflammatory activity, the oedema formation is measured using a plethysmometer and the inhibition activity is determined by ELISA methods. The results showed that the ethanol extract of Ketumbar leaves by the dose of 125 mg/kg BW, 250 mg/kg BW, and 500 mg/kg BW was significantly inhibitted COX-2 valued 65,61%, 76,83%, and 62,93%. The anti-inflammatory activity was shown by inhibiting oedema valued of 62.26%, 70.59%, and 54.90% respectively. These findings suggested that the ethanol extract of Ketumbar leaves had anti-inflammatory activity, that was possibly mediated through inhibition of COX-2 enzymes
Utilization of Unprocessed Sugarcane Bagasse and Coffee Waste into Soap Products Rachmaini, Fitri; Abdillah, Rahmad; Gumala, Azhoma; Srangenge, Yoneta
Warta Pengabdian Andalas Vol 32 No 4 (2025)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.32.04.473-479.2025

Abstract

The increasing by-products from sugarcane and coffee consumption have resulted in a greater volume of sugarcane bagasse and coffee waste with potential environmental impacts. Physically and chemically, coffee and sugarcane waste can be processed into soap products without further processing. This community service activity aimed to provide education and practical skills in utilising coffee and sugarcane waste as raw materials for hand soap production. The activity was conducted at the Baitussalam Mosque in Gadut, Padang City, with 20 participants. The implementation methods included material presentation, demonstrations, and hands-on practice in liquid soap formulation. The soap formula used sugarcane and coffee waste as the main ingredients with additional components including Texapon as a surfactant, EDTA as a chelating agent, salt as a viscosity regulator, warm water, and fragrance. The findings indicated that participants comprehended the potential of utilising sugarcane and coffee waste, allowing them to produce a basic liquid soap product for daily usage. Soap made from sugarcane and coffee waste has the potential to become an organic product with antioxidant and antimicrobial benefits for the skin. This activity aims to increase public awareness of the importance of waste management and promote the development of environmentally friendly, nature-based creative enterprises.
Co-Authors Azhoma Gumala Ifora, Ifora Rachmaini, Fitri Rahmad Abdillah Sintia, Bella