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All Journal INDOGENIUS International Journal of Health, Engineering and Technology
Nadam Adi Reksa
Universitas Negeri Semarang
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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The Use of Gas Chromatography in the Analysis of Pharmaceutical Compounds: A Literature Review Hasna Nisrina Huwaida Isfaizah; Mely Rosalinda; Salwa Roihana; Nadam Adi Reksa; Halyza Nada Kirana; Sayna Wahyu Ananta; Muhammad Ni’am Maulana
INDOGENIUS Vol 5 No 2 (2026): INDOGENIUS
Publisher : Department of Publication of Inspirasi Elburhani Foundation Desa. Pamokolan, Kecamatan Cihaurbeuti, Kabupaten Ciamis, Provinsi Jawa Barat, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/igj.v5i2.964

Abstract

Background & Objective: This review examines key advancements and applications of gas chromatography in pharmaceutical drug analysis by exploring innovations in instrumentation, sample-preparation strategies, and analytical performance across biological and non-biological matrices. The primary objective is to summarize recent progress in GC, GC-MS, and GC-MS/MS technologies and evaluate their effectiveness in detecting volatile and semi-volatile compounds, impurities, residual solvents, and degradation products. Method: A systematic search of indexed literature from 2015 to 2025 was performed using predefined inclusion criteria involving thematic relevance, completeness of data, and the direct application of GC methods. Result: Findings indicate that column selection, detector type, extraction approaches, and derivatization techniques markedly influence sensitivity, linearity, and quantification accuracy for analytes such as sibutramine, favipiravir, diclofenac, volatile anesthetics, cannabinoids, and phytochemicals. The discussion highlights that hybrid technologies, precise temperature programming, and optimized sample clean-up substantially enhance analytical performance. Conclusion: The review concludes that gas chromatography remains a critical analytical platform for pharmaceutical quality control and drug-stability evaluation across research and clinical settings.
Literature Review: Optimization Of Tablet Formula With Variations In Binder Type On The Physical Properties Of Tablets Dias Firda Dias Firda; Nadam Adi Reksa; Auryn Difani Marfanie; Adelliana Putri Puspitasari; Mely Rosalinda
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.820

Abstract

Tablets are a widely used pharmaceutical dosage form due to their stability, dosage accuracy, ease of production, and ease of use. One important factor influencing tablet quality is the use of binders, which play a role in increasing interparticle cohesion and mechanical strength. This study aims to evaluate the effect of varying binder types and concentrations on the physical characteristics and performance of tablets, including hardness, friability, disintegration time, and dissolution profile. The method used was a literature review with a descriptive analytical approach based on scientific articles from indexed journals. The results of the study indicate that the type of binder significantly influences tablet properties. Synthetic binders such as polyvinylpyrrolidone (PVP) and Avicel tend to produce more consistent hardness and lower friability, while natural binders such as starch, gelatin, pectin, and mucilage show wider variation in results depending on the source and process. Increasing binder concentration generally increases hardness and decreases friability, but can prolong disintegration time and decrease dissolution rate. Therefore, optimal tablet formulation is achieved through a balance between mechanical strength and drug release capability, by using binders at optimum concentrations and considering interactions with other excipients and the manufacturing method.
Co-Authors Adelliana Putri Puspitasari Auryn Difani Marfanie Dias Firda Dias Firda Halyza Nada Kirana Hasna Nisrina Huwaida Isfaizah Mely Rosalinda Muhammad Ni’am Maulana Salwa Roihana Sayna Wahyu Ananta