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All Journal INDOGENIUS International Journal of Health, Engineering and Technology
Adelliana Putri Puspitasari
Universitas Negeri Semarang
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Systematic Review: The Use of FTIR Spectroscopy for Pharmaceutical Analysis, Herbal Medicine, and the Identification of Chemical Compounds Mita Rasyida; Muhammad Adi Utama; Faneshia Nabil Ayushita; Aulia Jihan Kamila; Adelliana Putri Puspitasari; Lubna Nurul Mumtazah; Clarissa Zuha Swari
INDOGENIUS Vol 5 No 2 (2026): INDOGENIUS
Publisher : Department of Publication of Inspirasi Elburhani Foundation Desa. Pamokolan, Kecamatan Cihaurbeuti, Kabupaten Ciamis, Provinsi Jawa Barat, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/igj.v5i2.966

Abstract

Background & Objective: Fourier Transform Infrared Spectroscopy (FTIR) is a vibrational spectroscopic technique widely used to identify functional groups and characterize molecular structures based on infrared absorption patterns. This literature review aims to evaluate the application of FTIR in pharmaceutical and herbal analysis, particularly for identifying active pharmaceutical ingredients, detecting adulterants, characterizing secondary metabolites, and determining drug content in pharmaceutical preparations. Method: This review employed a systematic literature review approach, including database searching, article screening based on inclusion and exclusion criteria, and narrative synthesis of qualitative and quantitative findings from 21 selected studies related to FTIR applications in pharmaceutical and herbal products. Result: The reviewed studies demonstrated that FTIR provides rapid, nondestructive, and environmentally friendly analysis with minimal sample preparation. FTIR showed excellent linearity, accuracy, and precision for quantitative analysis, with results comparable to standard analytical methods. In addition, FTIR was effective in detecting adulterants such as paracetamol and dexamethasone in herbal medicines through characteristic fingerprint peaks. The technique also showed broad applicability for routine quality control in pharmaceuticals and herbal products. Conclusion: FTIR is a versatile, rapid, and green analytical technique suitable for screening, qualitative identification, and simple quantitative analysis in pharmaceutical and herbal products. Although FTIR has limitations, including lower sensitivity compared to chromatographic methods and signal overlap in complex matrices, it remains a reliable and practical tool for routine quality control applications.
Literature Review: Optimization Of Tablet Formula With Variations In Binder Type On The Physical Properties Of Tablets Dias Firda Dias Firda; Nadam Adi Reksa; Auryn Difani Marfanie; Adelliana Putri Puspitasari; Mely Rosalinda
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.820

Abstract

Tablets are a widely used pharmaceutical dosage form due to their stability, dosage accuracy, ease of production, and ease of use. One important factor influencing tablet quality is the use of binders, which play a role in increasing interparticle cohesion and mechanical strength. This study aims to evaluate the effect of varying binder types and concentrations on the physical characteristics and performance of tablets, including hardness, friability, disintegration time, and dissolution profile. The method used was a literature review with a descriptive analytical approach based on scientific articles from indexed journals. The results of the study indicate that the type of binder significantly influences tablet properties. Synthetic binders such as polyvinylpyrrolidone (PVP) and Avicel tend to produce more consistent hardness and lower friability, while natural binders such as starch, gelatin, pectin, and mucilage show wider variation in results depending on the source and process. Increasing binder concentration generally increases hardness and decreases friability, but can prolong disintegration time and decrease dissolution rate. Therefore, optimal tablet formulation is achieved through a balance between mechanical strength and drug release capability, by using binders at optimum concentrations and considering interactions with other excipients and the manufacturing method.
Co-Authors Aulia Jihan Kamila Auryn Difani Marfanie Clarissa Zuha Swari Dias Firda Dias Firda Faneshia Nabil Ayushita Lubna Nurul Mumtazah Mely Rosalinda Mita Rasyida Muhammad Adi Utama Nadam Adi Reksa