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All Journal INDOGENIUS Promotor: Jurnal Mahasiswa Kesehatan Masyarakat
Muhammad Adi Utama
Universitas Negeri Semarang
Nursing Public Health Other

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Systematic Review: The Use of FTIR Spectroscopy for Pharmaceutical Analysis, Herbal Medicine, and the Identification of Chemical Compounds Mita Rasyida; Muhammad Adi Utama; Faneshia Nabil Ayushita; Aulia Jihan Kamila; Adelliana Putri Puspitasari; Lubna Nurul Mumtazah; Clarissa Zuha Swari
INDOGENIUS Vol 5 No 2 (2026): INDOGENIUS
Publisher : Department of Publication of Inspirasi Elburhani Foundation Desa. Pamokolan, Kecamatan Cihaurbeuti, Kabupaten Ciamis, Provinsi Jawa Barat, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/igj.v5i2.966

Abstract

Background & Objective: Fourier Transform Infrared Spectroscopy (FTIR) is a vibrational spectroscopic technique widely used to identify functional groups and characterize molecular structures based on infrared absorption patterns. This literature review aims to evaluate the application of FTIR in pharmaceutical and herbal analysis, particularly for identifying active pharmaceutical ingredients, detecting adulterants, characterizing secondary metabolites, and determining drug content in pharmaceutical preparations. Method: This review employed a systematic literature review approach, including database searching, article screening based on inclusion and exclusion criteria, and narrative synthesis of qualitative and quantitative findings from 21 selected studies related to FTIR applications in pharmaceutical and herbal products. Result: The reviewed studies demonstrated that FTIR provides rapid, nondestructive, and environmentally friendly analysis with minimal sample preparation. FTIR showed excellent linearity, accuracy, and precision for quantitative analysis, with results comparable to standard analytical methods. In addition, FTIR was effective in detecting adulterants such as paracetamol and dexamethasone in herbal medicines through characteristic fingerprint peaks. The technique also showed broad applicability for routine quality control in pharmaceuticals and herbal products. Conclusion: FTIR is a versatile, rapid, and green analytical technique suitable for screening, qualitative identification, and simple quantitative analysis in pharmaceutical and herbal products. Although FTIR has limitations, including lower sensitivity compared to chromatographic methods and signal overlap in complex matrices, it remains a reliable and practical tool for routine quality control applications.
Article Review: The Effect of Disintegrant Type on Tablet Disintegration Time and Dissolution Rate Nur Shifa Rahmadina; Fathiya Nauratun Nafiah; Isna Nur Rahmawati; Anisa Jauzaa' Hasanah; Muhammad Adi Utama
PROMOTOR Vol. 9 No. 4 (2026): AGUSTUS
Publisher : Universitas Ibn Khaldun Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32832/pro.v9i4.2581

Abstract

Tablets are the most dominant dosage form used in therapeutic practice. Disintegrant excipients are known to directly exert a significant influence on the primary quality evaluation of tablets, namely disintegration time and dissolution rate. Differences in the characteristics of various types of disintegrants lead to variations in disintegration time and dissolution performance. This study aims to examine the effect of disintegrant type on tablet disintegration time and dissolution rate. The study was conducted using a systematic literature review (SLR) method to identify, analyze, understand, and interpret relevant previous studies. The results indicate that the type of disintegrant is a key parameter determining disintegration time and dissolution rate through water penetration, particle expansion, and matrix fragmentation. Crospovidone is effective for rapid disintegration; croscarmellose sodium is suitable for hard tablets and hydrophobic active ingredients; whereas sodium starch glycolate carries a risk of gelling at high concentrations, thereby inhibiting dissolution. The effectiveness of disintegrants is influenced by concentration, manufacturing methods, and formulation accuracy. Natural disintegrants (mucilage, MCC, DBP, chitosan, modified starch, and seed powder) have the potential to serve as alternatives to synthetic disintegrants.
Co-Authors Adelliana Putri Puspitasari Anisa Jauzaa' Hasanah Aulia Jihan Kamila Clarissa Zuha Swari Faneshia Nabil Ayushita Fathiya Nauratun Nafiah Isna Nur Rahmawati Lubna Nurul Mumtazah Mita Rasyida Nur Shifa Rahmadina