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All Journal INDOGENIUS International Journal of Health, Engineering and Technology
Clarissa Zuha Swari
Universitas Negeri Semarang
Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Dentistry Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Nursing Public Health Veterinary

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Systematic Review: The Use of FTIR Spectroscopy for Pharmaceutical Analysis, Herbal Medicine, and the Identification of Chemical Compounds Mita Rasyida; Muhammad Adi Utama; Faneshia Nabil Ayushita; Aulia Jihan Kamila; Adelliana Putri Puspitasari; Lubna Nurul Mumtazah; Clarissa Zuha Swari
INDOGENIUS Vol 5 No 2 (2026): INDOGENIUS
Publisher : Department of Publication of Inspirasi Elburhani Foundation Desa. Pamokolan, Kecamatan Cihaurbeuti, Kabupaten Ciamis, Provinsi Jawa Barat, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56359/igj.v5i2.966

Abstract

Background & Objective: Fourier Transform Infrared Spectroscopy (FTIR) is a vibrational spectroscopic technique widely used to identify functional groups and characterize molecular structures based on infrared absorption patterns. This literature review aims to evaluate the application of FTIR in pharmaceutical and herbal analysis, particularly for identifying active pharmaceutical ingredients, detecting adulterants, characterizing secondary metabolites, and determining drug content in pharmaceutical preparations. Method: This review employed a systematic literature review approach, including database searching, article screening based on inclusion and exclusion criteria, and narrative synthesis of qualitative and quantitative findings from 21 selected studies related to FTIR applications in pharmaceutical and herbal products. Result: The reviewed studies demonstrated that FTIR provides rapid, nondestructive, and environmentally friendly analysis with minimal sample preparation. FTIR showed excellent linearity, accuracy, and precision for quantitative analysis, with results comparable to standard analytical methods. In addition, FTIR was effective in detecting adulterants such as paracetamol and dexamethasone in herbal medicines through characteristic fingerprint peaks. The technique also showed broad applicability for routine quality control in pharmaceuticals and herbal products. Conclusion: FTIR is a versatile, rapid, and green analytical technique suitable for screening, qualitative identification, and simple quantitative analysis in pharmaceutical and herbal products. Although FTIR has limitations, including lower sensitivity compared to chromatographic methods and signal overlap in complex matrices, it remains a reliable and practical tool for routine quality control applications.
Systematic Literature Review: The Effect Of Different Binders On Paracetamol Tablets Nadine Ayu Syaima Gustaf Prins; Iqlima Farah Novantri; Jessica Putri Sinaga; Clarissa Zuha Swari
International Journal of Health Engineering and Technology Vol. 5 No. 1 (2026): IJHET MAY 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v5i1.840

Abstract

This study aims to examine the effect of different binders on the physical quality of paracetamol tablets using the Systematic Literature Review (SLR) method. Paracetamol tablets are one of the preparations widely used as analgesics and antipyretics, so the choice of binder plays an important role in determining tablet quality, such as hardness, friability, disintegration time, dissolution, and physical and chemical stability. The method used is a literature study of various studies related to variations in binders in paracetamol tablet formulations and evaluation of their physical quality. The results of the study indicate that the type and concentration of binders have a significant effect on tablet characteristics. Binders such as PVP, gelatin, kawista pectin, konjac glucomannan, durian seed starch, cassava starch, pregelatinized corn starch phosphate, and various other natural starches show different effects on tablet hardness, friability, disintegration time, and dissolution. Natural binders such as pectin and modified starch show the most optimal results because they are able to produce tablets with good physical quality while maintaining optimal drug release. While synthetic binders such as PVP and gelatin provide strong binding strength and improve tablet stability, their use in high concentrations can prolong disintegration time and decrease dissolution. Overall, selecting the right binder is crucial for producing paracetamol tablets that meet pharmacopoeial requirements and provide optimal therapeutic efficacy.
Co-Authors Adelliana Putri Puspitasari Aulia Jihan Kamila Faneshia Nabil Ayushita Iqlima Farah Novantri Jessica Putri Sinaga Lubna Nurul Mumtazah Mita Rasyida Muhammad Adi Utama Nadine Ayu Syaima Gustaf Prins