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All Journal JPSCR : Journal of Pharmaceutical Science and Clinical Research Journal Pharmaceutical Science and Application (JPSA)
Agung Endro Nugroho
Faculty of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Environmental Science Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Predictors of Blood Pressure Target Achievement in Tolaki and Muna Ethnic Groups Undergoing Candesartan Cilexetil Monotherapy: A Quasi-Experimental Study Mesi Leorita; Zullies Ikawati; Agung Endro Nugroho; Ismail Setyapranoto
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 3 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i3.110176

Abstract

Therapy adherence, sociodemographic factors, and lifestyle are factors that influence the achievement of blood pressure targets in hypertensive patients. This study aims to compare and examine the impact of therapy adherence, Sociodemographic, ethnicity, and lifestyle on the achievement of blood pressure targets in hypertensive patients of Muna and Tolaki ethnicities undergoing candesartan cilexetil monotherapy. This study employed a quasi-experimental design with a comparison group approach. A total of 147 patients were selected via consecutive sampling and categorized by ethnicity: Tolaki (n = 75) and Muna (n = 72). Both groups received a standardized dose of Candesartan Cilexetil (8 mg). The primary outcome was the change in blood pressure from baseline (pretest) to day 30 (posttest). Adherence, monitored via pill count, along with sociodemographic and lifestyle factors, was analyzed as a covariate to ensure a robust evaluation of the treatment's clinical impact across both ethnic groups. There was no significant difference in therapy adherence between participants of both ethnicities (p = 0.78). However, Tolaki participants experienced a greater reduction in 30-day systolic and diastolic blood pressure compared to Muna participants (p = 0.00). Furthermore, a greater percentage of Tolaki participants achieved blood pressure therapy targets (76%) compared to Muna participants (15.28%) (p < 0.001). Multivariate logistic regression analysis revealed that two variables that most significantly influence the attainment of blood pressure objectives are ethnicity (Tolaki ethnicity) (OR 21.44, 95% CI 6.69–53.40, and p=0.00) and a high level of therapy adherence (OR 10.89, 95% CI 2.96–40.07, and p=0.00). Ethnicity and therapy adherence are two important factors that need to be considered in efforts to achieve blood pressure therapy targets in the Tolaki and Muna tribes undergoing candesartan cilexetil monotherapy.
Antibiotics Drug Use Evaluation Among Patients With Kidney Disorder in PKU Muhammadiyah Hospital of Yogyakarta Fentyana Dwi Rilawati; Agung Endro Nugroho; Inayati
Journal Pharmaceutical Science and Application Vol. 1 No. 1 (2012): Journal Pharmaceutical Science and Application (JPSA)
Publisher : Pharmacy Department, Math and Sciences Faculty, Udayana Univerity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JPSA.2012.v01.i01.p02

Abstract

Antibiotic that appropriately as used anti-infective has drug a great success in reducing morbidity and mortality rates resulted from various infectious diseases, leading its increasing usage. Antibiotic are generally eliminated through kidney. Patients with kidney disorder, dosage adjustment is recommended for certain antibiotics. This research aims at evaluating the use of antibiotics among patients with kidney disorder in the inpatient wards of PKU Muhammadiyah Hospital Yogyakarta. Data collection was done retrospectively based on medical record data of inpatients meeting both inclusion and exclusion criteria in PKU Muhammadiyah Hospital Yogyakarta. Data processing was done by using a descriptive analytical technique. Result of the study shows that there were 76 patients with kidney disorder using antibiotics and meet inclusion and exclusion criteria. In this study patients wasn’t shown an indications of infection is aproximately 75,00% (57 patients) and patient with indication infection were 25,00% (19 patients). From those who have an appropriate indication, it is just 21,05% (16 patient) have an appropriate medication, 23,68% (18 patient) is right patient and 22,37% (17 patient) have an appropriate doses. Clinical outcome of those 19 patient is good (14 patient) with inpatient duration less than 7 days for 12 patient. Total 76 patient with renal disorder who received antibiotics, 21,05% (16 patients) have inappropriate doses which is mean there is no doses adjusment according to the creatinine clearance of each patient. Keywords: Antibiotics; Kidney Disorders; Rational Drug; Dose
Co-Authors Fentyana Dwi Rilawati Inayati Ismail Setyapranoto Mesi Leorita Zullies Ikawati