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All Journal JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Mandala Pharmacon Indonesia Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian Masyarakat
Mesi Leorita
Faculty Of Pharmacy, Universitas Gadjah Mada, Yogyakarta, Indonesia Faculty Of Pharmacy, Universitas Halu Oleo, Kendari, Southeast Sulawesi, Indonesia
Computer Science & IT Education Environmental Science Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Other

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Efek Imunomodulator Ekstrak Etanol Spons Xestospongia Sp. Terhadap Aktivitas Fagositosis Makrofag Pada Mencit Jantan Galur Balb/C Adryan Fristiohady; Wahyuni Wahyuni; Fadhliyah Malik; Mesi Leorita; Muhammad Ilyas Yusuf; Hendra Febriansyah; Sahidin Sahidin
Jurnal Mandala Pharmacon Indonesia Vol. 5 No. 01 (2019): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi STIKES Mandala Waluya Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v5i01.38

Abstract

Imunomodulator merupakan bahan yang dapat mengembalikan ketidakseimbangan sistem imun. Spons Xestospongia Sp. diduga mengandung senyawa-senyawa aktif yang berperan sebagai agen imunomodulator. Penelitian ini dilakukan untuk mengetahui pengaruh pemberian ekstrak etanol Spons Xestospongia Sp. terhadap aktivitas fagositosis makrofag. Sebanyak dua puluh empat ekor mencit jantan galur Balb/C umur 2-3 bulan dengan berat badan 20-30 gram dibagi ke dalam 6 kelompok. Kelompok pertama mendapat pemberian ekstrak etanol Spons Xestospongia Sp. 100 mg/kgBB, kelompok kedua mendapat pemberian ekstrak etanol Spons Xestospongia Sp. 200 mg/kgBB, kelompok ketiga mendapat pemberian ekstrak etanol Spons Xestospongia Sp. 300 mg/kgBB dan kelompok keempat mendapat pemberian ekstrak etanol Spons Xestospongia Sp. 400 mg/kgBB. Kelompok kontrol positif mendapat ekstrak Phyllanthus niruri Linn. (Stimuno®) 0,13 mg/gBB dan kelompok kontrol negatif mendapatkan Na-CMC 0,5%. Ekstrak diberikan secara peroral sejak hari pertama hingga ketujuh. Pada hari kedelapan masing-masing mencit diinjeksikan bakteri Staphylococcus aureus (SA) 0,5 mL secara intra peritoneal. Aktivitas sel makrofag dihitung dari apusan cairan peritoneum mencit. Peningkatan dosis ekstrak etanol Spons Xestospongia Sp. meningkatkan jumlah aktivitas fagositosis makrofag dari 24,25 % (Na-CMC), 34,25% (100 mg/kgBB), 47,00% (200 mg/kgBB), 59,50 % (300 mg/kgBB) dan 62,75% (400 mg/kgBB). Hasil penelitian menunjukan bahwa ekstrak etanol Spons Xestospongia Sp. memiliki potensi sebagai imunomodulator pada dosis 300 mg/kgBB dan 400 mg/kgBB dengan efektivitas yang tidak berbeda bermakna dengan kontrol positif (Stimuno®) dalam meningkatkan aktivitas fagositosis sel makrofag berdasarkan hasil uji statistik post hoc TUKEY (sig. > 0,05).
ANTIHYPERURICEMIA ACTIVITY OF WUALAE FRUIT (Etlingera elatior Jack R. M. Smith) ETHANOL EXTRACT IN VIVO Asriullah Jabbar; Wahyuni Wahyuni; Mesi Leorita; Muhammad Ilyas Yusuf; Sahidin Sahidin
Jurnal Farmasi Sains dan Praktis Vol 7 No 3 (2021): Supplementary Issue (The 4th National Pharmacy Conference 2021 Universitas Halu O
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v7i3.6083

Abstract

Plants Etlingera elatior (Wualae) is a family Zingiberaceae of ​​the genus Etlingera which has a large population in the world. The E. elatior plant is widely used empirically in the community to increase endurance and seasoning in fruit. In this study, ethanol extract was used to determine its potential and effectiveness as an antihyperuricemia (in vivo) was tested pharmacologically on Rattus novergicus L. In this study, twenty-four rats were grouped into six groups, namely the ethanol extract of wualae fruit at a dose (100 mg/kgBW, 200 mg/kgBW, 300 mg/kgBW, 400 mg/kgBW), and the negative control group Sodium CMC 0 .5%, and the positive control group used Allopurinol 10 mg/kgBW. Furthermore, To increase the value of uric acid levels, the rats were first induced with 250 mg/kgBW Potassium Oxonate via intraperitoneal (i.p). Furthermore, the preparation according to the treatment was given orally one hour later after the administration of potassium oxonate. At the hour (1, 2, 3), the blood was taken intravenously (i.v) through the rat's tail, and then the uric acid level was analyzed with a photometer. All doses used in this study, namely 100, 200, 300, and 400 mg/kgBW, showed that they could reduce uric acid overall. The effective dose used is the dose (300 mg/kgBW, 400 mg/kgBW). This research can be concluded that the ethanol extract of the fruit of Etlingera elatior (Jack) R.M. Smith (Wualae) has potential as an antihyperuricemia (uric acid) and can be developed as a traditional medicine
DETEKSI DINI DAN EDUKASI PENYAKIT ASAM URAT DI LINGKUNGAN KELURAHAN KAMBU Fery Indradewi Armadany; Mesi Leorita; Rifa'atul Mahmudah; Nur Illyyin Akib; Aisyah Said; Dewa Gede Sandhi Yoga; Dwi Sinta; Fina Mei Sridewi; Intan Permatasari Ali Syadikin; Kadek Riani; Ketut Nesa Sawitri; Nur Alifa Muliatan Ramadhani
BESIRU : Jurnal Pengabdian Masyarakat Vol. 3 No. 1 (2026): BESIRU : Jurnal Pengabdian Masyarakat, Januari 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v3i1.2199

Abstract

The increasing prevalence of gout in Indonesia, particularly among the elderly, emphasizes the importance of community-based education and early detection. This community service activity aimed to improve the knowledge of residents of Kambu Village regarding gout, including its risk factors, clinical symptoms, and preventive measures. The program was conducted by the Pharmacy Profession Study Program of Halu Oleo University in collaboration with the UHO Educational Pharmacy and Mokoau Community Health Center during November–December 2025. The methods applied included pre-test, health education sessions, leaflet distribution, interactive discussions, post-test, and free examinations of blood pressure and uric acid levels. A total of 43 participants were involved. The results indicated a significant improvement in participants’ knowledge, as reflected by an increase in correct response rates from 59% in the pre-test to 98% in the post-test. This activity is expected to contribute to gout prevention and improvement of community health outcomes.
SOSIALISASI DAN EDUKASI: PENINGKATAN KESADARAN MASYARAKAT TENTANG PENGGUNAAN OBAT YANG RASIONAL DI PUSKESMAS KONDA, KABUPATEN KONAWE SELATAN, PROVINSI SULAWESI TENGGARA Irnawati; Loly Subhiaty Idrus; Ari Sartina; Mesi Leorita; Hartina La Ndia; Javier Wabula; Natarios Gusti Buangin; Ni Made Devi; Putu Wulandari; Sinta Indrawati; Siti Jumariati; Sonia Maryanti Lakapu
BESIRU : Jurnal Pengabdian Masyarakat Vol. 3 No. 1 (2026): BESIRU : Jurnal Pengabdian Masyarakat, Januari 2026
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v3i1.2257

Abstract

Penggunaan obat yang rasional merupakan salah satu komponen penting dalam pelayanan kesehatan, khususnya difasilitas kesehatan tingkat pertama seperti puskesmas. Di wilayah pedesaan dan semi-perkotaan pengetahuan masyarakat tentang penggunaan obat yang rasional masih tergolong rendah. Kondisi ini diperburuk oleh minimnya interaksi masyarakat dengan tenaga kesehatan profesional. Akibatnya, penggunaan obat secara mandiri tanpa panduan yang tepat menjadi hal yang umum terjadi, dengan risiko yang cukup tinggi, seperti kesalahan dosis, penggunaan obat kadaluwarsa, serta ketergantungan pada obat-obatan tertentu tanpa resep dokter Tujuan dari kegiatan ini adalah untuk memberikan edukasi dan pengetahuan mengenai pentingnya kesadaran masyarakat tentang rasional penggunaan obat. Hasil dari kegiatan pengabdian ini adalah melalui sosalisasi ini meningkatkan pemahaman masyarakat Kecamatan Konda mengenai penggunaan obat yang aman dan rasional. Dengan demikian, diharapkan masyarakat dapat menggunakan obat secara tepat, efektif, dan bertanggung jawab demi keselamatan dan kualitas kesehatan yang lebih baik.
Predictors of Blood Pressure Target Achievement in Tolaki and Muna Ethnic Groups Undergoing Candesartan Cilexetil Monotherapy: A Quasi-Experimental Study Mesi Leorita; Zullies Ikawati; Agung Endro Nugroho; Ismail Setyapranoto
JPSCR: Journal of Pharmaceutical Science and Clinical Research Vol 10, No 3 (2025)
Publisher : Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jpscr.v10i3.110176

Abstract

Therapy adherence, sociodemographic factors, and lifestyle are factors that influence the achievement of blood pressure targets in hypertensive patients. This study aims to compare and examine the impact of therapy adherence, Sociodemographic, ethnicity, and lifestyle on the achievement of blood pressure targets in hypertensive patients of Muna and Tolaki ethnicities undergoing candesartan cilexetil monotherapy. This study employed a quasi-experimental design with a comparison group approach. A total of 147 patients were selected via consecutive sampling and categorized by ethnicity: Tolaki (n = 75) and Muna (n = 72). Both groups received a standardized dose of Candesartan Cilexetil (8 mg). The primary outcome was the change in blood pressure from baseline (pretest) to day 30 (posttest). Adherence, monitored via pill count, along with sociodemographic and lifestyle factors, was analyzed as a covariate to ensure a robust evaluation of the treatment's clinical impact across both ethnic groups. There was no significant difference in therapy adherence between participants of both ethnicities (p = 0.78). However, Tolaki participants experienced a greater reduction in 30-day systolic and diastolic blood pressure compared to Muna participants (p = 0.00). Furthermore, a greater percentage of Tolaki participants achieved blood pressure therapy targets (76%) compared to Muna participants (15.28%) (p < 0.001). Multivariate logistic regression analysis revealed that two variables that most significantly influence the attainment of blood pressure objectives are ethnicity (Tolaki ethnicity) (OR 21.44, 95% CI 6.69–53.40, and p=0.00) and a high level of therapy adherence (OR 10.89, 95% CI 2.96–40.07, and p=0.00). Ethnicity and therapy adherence are two important factors that need to be considered in efforts to achieve blood pressure therapy targets in the Tolaki and Muna tribes undergoing candesartan cilexetil monotherapy.
Co-Authors Agung Endro Nugroho Aisyah Said Ari Sartina Asriullah Jabbar Dewa Gede Sandhi Yoga Dwi Sinta Fadhliyah Malik Fery Indradewi Armadany Fina Mei Sridewi Fristiohady, Adryan Hartina La Ndia Hendra Febriansyah Intan Permatasari Ali Syadikin Irnawati Ismail Setyapranoto Javier Wabula Kadek Riani Ketut Nesa Sawitri Loly Subhiaty Idrus Muhammad Ilyas Y Muhammad Yusuf Natarios Gusti Buangin Ni Made Devi Nur Alifa Muliatan Ramadhani Nur Illyyin Akib Putu Wulandari Rifa'atul Mahmudah Sahidin Sahidin Sinta Indrawati Siti Jumariati Sonia Maryanti Lakapu Wahyuni Wahyuni Zullies Ikawati