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All Journal Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Daarul Ilmi: Jurnal Pengabdian Kepada Masyarakat
Nurul Sulistia Azzahra
Universitas Bakti Tunas Husada
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Literatur Review: Strategi dan Perkembangan Computer-Aided Drug Design (Cadd) untuk Identifikasi Lead Compound Antikanker dalam Konteks Kimia Medisinal dan Farmasi Nurul Sulistia Azzahra; Saeful Amin
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 4 (2025): Oktober : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i4.875

Abstract

Cancer remains the second leading cause of death worldwide, while conventional therapies are often limited by toxicity, resistance, and high costs. Advances in bioinformatics and artificial intelligence have established Computer-Aided Drug Design (CADD) as an efficient tool for modern drug discovery. Integrating medicinal chemistry, structural biology, and computational modeling, CADD accelerates the identification and optimization of anticancer candidates through in silico approaches such as molecular docking, molecular dynamics, QSAR, and pharmacophore modeling. This review systematically analyzed literature from PubMed, ScienceDirect, ResearchGate, and Google Scholar (2015–2025) focusing on in silico studies related to anticancer drug design. Selected articles were evaluated based on molecular targets, compound types, CADD techniques, and major findings.The results reveal that CADD effectively identifies natural and synthetic compounds targeting key cancer proteins including EGFR, CDK2, PI3K/Akt/mTOR, and p53. Integration with artificial intelligence enhances screening efficiency, prediction accuracy, and ADMET assessment. Overall, CADD represents a crucial strategy to accelerate the discovery of selective and clinically promising anticancer drugs.
Pengaruh Program Promosi Kesehatan Interaktif terhadap Peningkatan Pengetahuan HIV/AIDS pada Remaja Ilham Alifiar; Rani Putri Lutfhiani; Nadya Nasywa Saputri; Devi Sarah Fauziah; Ai Nuraisah; Suci Rahayu Nurlichan; Eki Muhammad Ramdhani; Ratna Wulandari; Nurul Sulistia Azzahra; Yuyun Yunizar; Novita Deris Suryaman; Hilma Tri Anisa; Syakila Syalsa Reiza Putri; Nadhira Alika Putri; Tiara Putri Laksana; Cici Apriliani; Trisna Mutiara Damayanti
Daarul Ilmi: Jurnal Pengabdian Kepada Masyarakat Vol. 3 No. 2 (2025): Daarul Ilmi: Jurnal Pengabdian Kepada Masyarakat (Juli-Desember 2025)
Publisher : LPPM STIKes Muhammadiyah Ciamis

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52221/daipkm.v3i2.957

Abstract

Introduction: HIV/AIDS remains a significant public health problem that requires effective prevention strategies, particularly through increasing knowledge among adolescents, who are considered a vulnerable group. Objective: This community service activity aimed to improve and evaluate adolescents’ knowledge of HIV/AIDS through interactive health promotion as an effort to support HIV/AIDS prevention. Method: This study employed a pre-experimental design using a one-group pre-test and post-test approach. A total of 18 adolescents participated as respondents. The intervention consisted of interactive health education delivered through presentations and posters containing information about HIV/AIDS, modes of transmission, prevention strategies, as well as myths and facts. Knowledge levels were measured using a questionnaire consisting of 10 multiple-choice questions. Data were analyzed using the Wilcoxon test. Result: The results showed an increase in the mean knowledge score from 74.44 in the pre-test to 96.11 in the post-test. Statistical analysis indicated a significant difference between pre-test and post-test scores (p = 0.001). Conclusion: Health promotion with the theme “Smart Teens Without Risk: Recognize, Prevent, and Control HIV/AIDS” was effective in improving adolescents’ knowledge about HIV/AIDS
Co-Authors Ai Nuraisah Cici Apriliani Devi Sarah Fauziah Eki Muhammad Ramdhani Hilma Tri Anisa Ilham Alifiar Nadhira Alika Putri Nadya Nasywa Saputri Novita Deris Suryaman Rani Putri Lutfhiani Ratna Wulandari Saeful Amin Suci Rahayu Nurlichan Syakila Syalsa Reiza Putri Tiara Putri Laksana Trisna Mutiara Damayanti Yuyun Yunizar