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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Nursing and Health Sciences Journal (NHSJ)
Rini Pratiwi
Department of Parasitology, Faculty of Medicine, Universitas Indo Global Mandiri
Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Medicine & Pharmacology Neuroscience Nursing Public Health

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Interleukin 10 gene promoter polymorphism –819 T/C modulates IL-10 levels independently of PGE2 in multibacillary leprosy Fitriyanti; Lipinwati; Attiya Istarini; Tia Wida Ekaputri; Niken Irfa Nastiti; I Made Dwi Mertha Adnyana; Rini Pratiwi
Nursing and Health Sciences Journal (NHSJ) Vol. 6 No. 2 (2026): June 2026
Publisher : KHD-Production

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53713/nhsj.v6i2.684

Abstract

The IL-10 –819 T/C promoter polymorphism influences cytokine production in leprosy, yet its functional interplay with serum IL-10 and prostaglandin E2 (PGE2) in Indonesian populations remains undefined. This study investigated its association with multibacillary (MB) leprosy susceptibility and systemic mediator levels. In a case–control design, 35 MB patients and 35 healthy controls from Banyuasin Regency, South Sumatra, were enrolled. PCR-RFLP was used for genotyping, and ELISA was used to quantify serum IL-10 and PGE2. Genotype and allele frequencies did not differ between groups (OR = 1.121; 95% CI: 0.439–2.863; p = 0.811), indicating no susceptibility effect. Serum IL-10 was significantly elevated in patients (median 2.15 pg/mL) versus controls (1.23 pg/mL; p = 0.033). Within cases, IL-10 exhibited a C-allele dose-dependent gradient (TT: 3.82; CT: 4.96; CC: 16.20 pg/mL), though statistically underpowered (H = 0.452; p = 0.798). PGE2 showed no intergroup differences (p = 0.142), nor correlations with genotype (p = 0.915) or IL-10 (rₛ = −0.057; p = 0.639). The IL-10 –819 T/C variant does not predict MB susceptibility but, in a pathogen-context-dependent manner, functionally amplifies IL-10 production. This genetic effect operates independently of systemic PGE2 regulation, highlighting distinct immunomodulatory pathways and supporting the CC genotype as a potential biomarker of immune-suppression severity.
RESTING ECOLOGY AND SPATIAL HETEROGENEITY OF FILARIASIS MOSQUITO VECTORS IN TROPICAL WETLANDS: IMPLICATIONS FOR INTEGRATED VECTOR CONTROL IN BANYUASIN, INDONESIA Rini Pratiwi; Peni Kusumasari; Fitriyanti
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 13 No. 2 (2026): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v13i2.963

Abstract

 Lymphatic filariasis remains a public health challenge in tropical wetland ecosystems, where mosquito resting ecology is still poorly understood despite its importance for vector survival and control effectiveness. This study analyzed resting behavior, species composition, and spatial heterogeneity across four endemic villages in Banyuasin, Indonesia. A total of 2,752 mosquitoes representing 26 species were collected, dominated by Mansonia uniformis, Culex tritaeniorhynchus, Culex vishnui, and Mansonia annulifera, accounting for over 70% of individuals. Spatial patterns revealed that vegetation-rich wetlands favored Mansonia, while agricultural landscapes supported Culex species. Most dominant species exhibited exophilic resting behavior, whereas Culex quinquefasciatus showed more endophilic tendencies. Peak resting activity occurred between 19:00 and 22:00. Although no infective filarial larvae were detected, the high abundance of competent vectors suggests continued transmission potential. These findings highlight the importance of integrating resting ecology and landscape heterogeneity into comprehensive vector surveillance and control strategies.
Co-Authors Adnyana , I Made Dwi Mertha Attiya Istarini Fitriyanti Fitriyanti Lipinwati Niken Irfa Nastiti Peni Kusumasari Tia Wida Ekaputri