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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Indonesian Journal of Global Health research Nursing and Health Sciences Journal (NHSJ) Sehat Rakyat: Jurnal Kesehatan Masyarakat SWARNA Ambidextrous : Journal of Innovation, Efficiency and Technology in Organization
Fitriyanti Fitriyanti
Department Of Dermatology, Faculty Of Medicine, Universitas Jambi
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Civil Engineering, Building, Construction & Architecture Computer Science & IT Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Health Professions Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Interleukin 10 gene promoter polymorphism –819 T/C modulates IL-10 levels independently of PGE2 in multibacillary leprosy Fitriyanti; Lipinwati; Attiya Istarini; Tia Wida Ekaputri; Niken Irfa Nastiti; I Made Dwi Mertha Adnyana; Rini Pratiwi
Nursing and Health Sciences Journal (NHSJ) Vol. 6 No. 2 (2026): June 2026
Publisher : KHD-Production

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53713/nhsj.v6i2.684

Abstract

The IL-10 –819 T/C promoter polymorphism influences cytokine production in leprosy, yet its functional interplay with serum IL-10 and prostaglandin E2 (PGE2) in Indonesian populations remains undefined. This study investigated its association with multibacillary (MB) leprosy susceptibility and systemic mediator levels. In a case–control design, 35 MB patients and 35 healthy controls from Banyuasin Regency, South Sumatra, were enrolled. PCR-RFLP was used for genotyping, and ELISA was used to quantify serum IL-10 and PGE2. Genotype and allele frequencies did not differ between groups (OR = 1.121; 95% CI: 0.439–2.863; p = 0.811), indicating no susceptibility effect. Serum IL-10 was significantly elevated in patients (median 2.15 pg/mL) versus controls (1.23 pg/mL; p = 0.033). Within cases, IL-10 exhibited a C-allele dose-dependent gradient (TT: 3.82; CT: 4.96; CC: 16.20 pg/mL), though statistically underpowered (H = 0.452; p = 0.798). PGE2 showed no intergroup differences (p = 0.142), nor correlations with genotype (p = 0.915) or IL-10 (rₛ = −0.057; p = 0.639). The IL-10 –819 T/C variant does not predict MB susceptibility but, in a pathogen-context-dependent manner, functionally amplifies IL-10 production. This genetic effect operates independently of systemic PGE2 regulation, highlighting distinct immunomodulatory pathways and supporting the CC genotype as a potential biomarker of immune-suppression severity.
Pemberdayaan Masyarakat Pascabanjir Bandang melalui Instalasi Wash Station, Edukasi, dan Penanganan Penyakit Kulit di Desa Batu Busuk, Kelurahan Lambung Bukit, Padang Fitriyanti Fitriyanti; Huntari Harahap; Riska Amalya Nasution
SWARNA: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 6 (2026): SWARNA : Jurnal Pengabdian Kepada Masyarakat, Juni, 2026
Publisher : LPPM Sekolah Tinggi Ilmu Ekonomi 45 Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55681/swarna.v5i6.3097

Abstract

Banjir bandang di Kelurahan Lambung Bukit, Kecamatan Pauh, Kota Padang pada 27 November 2025 menyisakan risiko penyakit kulit akibat paparan air tercemar yang berkepanjangan. Pengabdian ini bertujuan menginstalasi unit penjernihan air siap minum (wash station) guna memulihkan akses air bersih warga terdampak di Desa Batu Busuk RT 01 sampai RT 04, dan memberikan edukasi dan pelayanan penanganan penyakit kulit. Kegiatan berlangsung pada 28 Januari-28 Februari 2026 oleh tim mahasiswa Kedokteran, Profesi Dokter, dan S1 Keperawatan Universitas Jambi dalam program mahasiswa berdampak. Data klinis dikumpulkan sebagai karakterisasi kasus yang telah ditangani. Sebanyak 22 warga dengan diagnosis terbanyak dermatofitosis, dermatitis, skabies, dan kandidosis kutis, didominasi derajat ringan tanpa indikasi rujukan. Uji laboratorium air hasil filtrasi reverse osmosis dan ultraviolet menunjukkan kadar total coliform dan Escherichia coli sebesar 0 CFU per 100 mililiter mengindikasikan air yang dihasilkan memenuhi baku mutu Peraturan Menteri Kesehatan Nomor 2 Tahun 2023. Edukasi kesehatan kulit menggunakan leaflet diberikan kepada 30 peserta, terdiri atas 22 warga terdampak, 5 kader Puskesmas Pauh, dan 3 perwakilan kelurahan dengan pemahaman pada empat domain pengetahuan meningkat dari rerata 67,0% menjadi 89,7% pascaedukasi, sehingga program perlu dilanjutkan guna mempercepat pemulihan kesehatan kulit pascabencana.
Correlation Clinicopathological and Immunohistochemical Expression of Interleukin-6 (IL-6) in Keloid Fairuz Fairuz; Erisca Utami; Hasna Dewi; Fitriyanti Fitriyanti; Miftahurrahma Miftahurrahma; Budi Justitia; Mara Imam Taufiq Siregar; Humaryanto Humaryanto
Indonesian Journal of Global Health Research Vol 6 No 6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i6.5844

Abstract

IL-6 has been shown to enhance collagen synthesis and prolong the fibroblast proliferative phase, potentially contributing to uncontrolled keloid growth. However, despite its frequent mention in the literature as a crucial factor in keloid formation, studies specifically exploring the molecular mechanisms of IL-6 in fibroblast regulation and its interaction with other cytokines within keloid tissue remain limited. This study aims to further investigate the role of IL-6 in keloid matrix formation. This study is an analytical study conducted cross-sectionally. The samples used were patients diagnosed with keloids histopathologically based on microscopic criteria. Clinical data were taken from medical records and microscopic and immunohistochemical assessments using paraffin blocks available in the anatomical pathology laboratory of hospitals in Jambi city. There were 36 cases of keloids, aged between 12 and 42 years, mostly in women (66.7%), occurring in the trunk area (77.8%) 30 cases of recurrence (83.3%). We found 24 cases (77.8%) with strong IL-6 immunoexpression. There were 3 cases (8.3%) with no immunoexpression. There was a strong correlation between IL-6 immunoexpression and gender (p=0.03), age(0.04) and recurrence (p=0.02). The role of fibroblast cells is very important for the process of collagen formation in wound healing. The role of fibroblast cells is very important for the process of collagen formation in wound healing, where interleukin-6 in various theories and studies supports the process of collagen formation.
RESTING ECOLOGY AND SPATIAL HETEROGENEITY OF FILARIASIS MOSQUITO VECTORS IN TROPICAL WETLANDS: IMPLICATIONS FOR INTEGRATED VECTOR CONTROL IN BANYUASIN, INDONESIA Rini Pratiwi; Peni Kusumasari; Fitriyanti
Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Vol. 13 No. 2 (2026): Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Univers
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/jkk.v13i2.963

Abstract

 Lymphatic filariasis remains a public health challenge in tropical wetland ecosystems, where mosquito resting ecology is still poorly understood despite its importance for vector survival and control effectiveness. This study analyzed resting behavior, species composition, and spatial heterogeneity across four endemic villages in Banyuasin, Indonesia. A total of 2,752 mosquitoes representing 26 species were collected, dominated by Mansonia uniformis, Culex tritaeniorhynchus, Culex vishnui, and Mansonia annulifera, accounting for over 70% of individuals. Spatial patterns revealed that vegetation-rich wetlands favored Mansonia, while agricultural landscapes supported Culex species. Most dominant species exhibited exophilic resting behavior, whereas Culex quinquefasciatus showed more endophilic tendencies. Peak resting activity occurred between 19:00 and 22:00. Although no infective filarial larvae were detected, the high abundance of competent vectors suggests continued transmission potential. These findings highlight the importance of integrating resting ecology and landscape heterogeneity into comprehensive vector surveillance and control strategies.
Dual Periodicity and Molecular Evidence of Brugia Malayi Transmission Dynamics in Banyuasin District, South Sumatra, Indonesia Rini Pratiwi; Peni Kusumasari; Fitriyanti Fitriyanti; Widyastuti Widyastuti; Alfarobi Alfarobi
Sehat Rakyat: Jurnal Kesehatan Masyarakat Vol. 5 No. 3 (2026): Agustus 2026
Publisher : Yayasan Pendidikan Penelitian Pengabdian Algero

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54259/sehatrakyat.v5i3.7488

Abstract

Lymphatic filariasis remains one of the most neglected tropical diseases, characterized by complex transmission dynamics involving parasites, vectors, hosts, and environmental determinants. Understanding the periodicity of Brugia malayi and the molecular confirmation of potential vectors are crucial for optimizing control and elimination strategies in endemic regions. Objective: This study aimed to characterize the transmission dynamics of Brugia malayi by analyzing its microfilarial periodicity and confirming vector species through molecular identification. Methods: A cross-sectional field study was conducted from April 2017 to May 2018 in Banyuasin District, South Sumatra. Peripheral blood samples from humans and domestic cats, as well as adult mosquitoes, were collected and examined microscopically for microfilariae. Polymerase chain reaction (PCR) targeting the yACA gene of Brugia spp. was used for molecular confirmation. Microfilarial periodicity was assessed through hourly finger-prick sampling over 24 hours and analyzed using the Aikat and Das formula. Results: Two of six human subjects in Sedang Village were positive for Brugia malayi microfilariae with an average density of 150.3 mf/mL, while one cat from Muara Sugih was positive for Dirofilaria repens. PCR detected Brugia malayi DNA in two Mansonia spp. samples (I4 and I8) with 93–95% identity to reference strain MG030487.1. The periodicity exhibited a dual pattern diurnal (peak at 15:00) and subperiodic nocturnal distinct from the typical nocturnal rhythm reported elsewhere in Indonesia. Conclusion: The detection of dual periodicity and molecular confirmation of Brugia malayi in Mansonia spp. highlight potential adaptive transmission patterns influenced by local ecological conditions in Banyuasin’s wetland ecosystems.
Clinical Features, Risk Factors, and Adhesive Tape Test Examination for Scabies at the Olak Kemang Community Health Center and Putri Ayu Community Health Center in Jambi City Liza Oktaviani; Fitriyanti; Fairuz Quzwain; Rini Chrisna; Hafizah
Ambidextrous Journal of Innovation Efficiency and Technology in Organization Vol. 5 No. 02 (2026): Ambidextrous: Journal of Innovation, Efficiency and Technology in Organization
Publisher : Takaza Innovatix Labs Ltd.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61536/ambidextrous.v5i02.578

Abstract

Scabies is a contagious skin disease that remains a public health problem, especially in areas with high population density and poor sanitation. This study aims to determine the demographic characteristics, clinical presentation, risk factors, and adhesive tape test results in scabies patients at the Olak Kemang Community Health Center and the Putri Ayu Community Health Center in Jambi City. The study used a descriptive observational design with a cross-sectional approach. The population was all scabies patients treated at both community health centers during the study period, while a sample of 43 respondents was determined using the Lemeshow formula with a purposive sampling technique. The research instruments included a questionnaire on demographic characteristics and risk factors, a clinical observation sheet, and an adhesive tape test. Data were analyzed using univariate analysis in the form of frequency distributions and percentages. The results showed that most patients were school-aged children, females, had no education up to elementary school or equivalent, and were unemployed. Lesions were most commonly found on the upper and lower extremities, with papules as the dominant lesion. Most respondents had poor personal hygiene, unhealthy basic sanitation, and low socioeconomic status, while positive adhesive tape test results were found in 7.0% of respondents. This study concluded that the characteristics of scabies patients at the study site were dominated by behavioral and environmental factors, while the adhesive tape test only identified a small proportion of cases, making it more appropriate to use as a supporting examination for clinical diagnosis.
Co-Authors Adnyana , I Made Dwi Mertha Alfarobi Alfarobi Attiya Istarini Budi Justitia dewi, hasna Erisca Utami Fairuz Quzwain Fairuz Quzwain Hafizah Hafizah Harahap, Huntari Humaryanto Humaryanto Lipinwati Liza Oktaviani Mara Imam Taufiq Siregar Miftahurrahma Miftahurrahma Niken Irfa Nastiti Peni Kusumasari Peni Kusumasari Rini Chrisna Rini Pratiwi Rini Pratiwi Riska Amalya Nasution Tia Wida Ekaputri Widyastuti Widyastuti