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All Journal Jurnal Farmasi Udayana JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Jurnal Farmasi Indonesia Jurnal Mandala Pharmacon Indonesia Jurnal Insan Farmasi Indonesia Jurnal Kefarmasian Indonesia
Lukito Mindi Cahyo
Fakultas Farmasi Universitas Setia Budi Surakarta
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Physics Public Health

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Aktivitas Antioksidan Ekstrak dan Fraksi Daun Manggis (Garcinia mangostana) terhadap DPPH (1,1-Difenil-2-Pikrilhidrazil) Ghani Nurfiana; Lukito Mindi; Masyitah Novia
Jurnal Farmasi Indonesia Vol 14 No 1 (2017): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (630.407 KB) | DOI: 10.31001/jfi.v14i1.358

Abstract

Antioxidant is very important to keep human’s health because it can scavenge free radical. Garcinia mangostanaL. which is used by people as traditional herbal medicine and it has traditional name mangosteen is known contain of flavonoid, tannin and saponin. The aim of the experiment was to find out the antioxidant activity of extracts and fractions of mangosteen folium against the DPPH radicals (1,1-diphenyl-2-picrylhydrazyl) to determine the IC50 and classes of compounds that play a role in antioxidant activity assay.Mangosteen leaves were extracted by maceration method using 96% ethanol. Extract was partitionedwith water and n-hexane, and then with ethyl acetate. The antioxidant activity of fraction was tested against DPPH radicals. The test was conducted in 5 series of concentrations by adding 4.0 ml test solutions with 1.0 mlDPPH 0.45 mM. The radicals scavenging activity was measured with spectrophotometer at 517 nm wavelength anddetermined the IC50 value. The experiment used Rutin as positive control.The identification of the class of compounds can be carried out using the Thin Layer Chromatography (TLC) method whose results can be identified by spray reagents or compared with the standard standard. The result of the experiment showed that Mangosteen folium had antioxidant activity with IC50 of ethanol extract, n-hexane fraction, ethyl acetate fraction and water fraction: 17.64 μg / ml, 45.36 μg / ml, 13.71 μg / ml, 12.10 μg / ml respectively. The water fraction has the strongest activity compare to the other with the IC50 is almost near often Rutin’s IC50 is 15.24 μg as the positive control. Extracts and fractions of TLC with various spotting agents contain a class of compounds: flavonoids, saponins and steroids
Studi Inkompatibilitas Parenteral dan Penggunaan Antibiotika Pada Pasien Rawat Inap Di Rumah Sakit Surakarta Avianti Dewi Purwaningsih; Lukito Mindi Cahyo
Jurnal Farmasi Indonesia Vol 15 No 2 (2018): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (474.158 KB) | DOI: 10.31001/jfi.v15i2.452

Abstract

Intravenous admixtures is a process of admixtures sterile drugs with sterile intravenous solutions to produce a sterile preparation aimed at intravenous use. The scope of intravenous admixtures is to dissolve or reconstitute sterile powders, prepare simple intravenous injections, and prepare complex intravenous injections. Identification and evaluation of incompatibility events in the drug dispensing stage in the hospital aims to determine incompatibility events, know the prescription patterns of intravenous preparations, know the process of drug dispensing, determine the effect of pharmacist ability on incompatibility events, find out the incompatibility with outcome therapy, and incidence of incompatibility on antibiotic use. This research needs to be done because incompatibility is a high risk problem in a hospital. The study used experimental studies, namely to provide an understanding of the effect of quantitative incompatibility and observational studies to determine the incidence of antibiotic incompatibility. The samples used were inpatients in the hospital, excluding hemodialysis patients and labor patients. Data retrieval is done retrospectively, to obtain qualitative data and prospectively, to obtain quantitative data. The results of this study obtained the greatest antibiotic use was Ceftriaxone with NaCl solvents. Incompatibility occurring at 19.5% includes chemical and physics incompatibility. This study concluded that there was no significant relationship between the use of antibiotics and the incidence of incompatibility.
ISOLASI DAN IDENTIFIKASI BAKTERI PENGHASIL PROTEASE EKSTRASELULER DARI LIMBAH CAIR INDUSTRI TAHU Wiwi Kusumasari; Ana Indrayati; Lukito Mindi Cahyo
Jurnal Insan Farmasi Indonesia Vol 6 No 1 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i1.1266

Abstract

Tofu waste that is discharged into the aquatic environment has a negative impact on the quality of the water around the tofu liquid waste disposal site. Industrial enzyme production is currently dominated by proteases. Proteases in the pharmaceutical field support the absorption of proteins in the digestive tract, as active cosmetic ingredients. This study aims to isolate, identify protease-producing bacteria from tofu wastewater, determine the total protein content and enzyme activity index of 5 isolates of protease-producing bacteria. Tofu wastewater bacteria were isolated with Skim Milk Agar medium. 5 bacterial isolates were selected which produced the widest clear zones, different colony characters, identified by morphological tests, gram staining tests, and biochemical tests. Five isolates were made into a bacterial suspension isolated from crude protease extract and the protease level was determined using the Bicinchoninic Acid method, and the protease activity was tested. Five bacterial colonies showed that colony 1 and colony 2 included Gram positive bacteria, colonies 3, 4 and 5 included Gram negative bacteria. The value of total protein content in the tofu industrial wastewater from the five colonies respectively: 219.93; 833,267; 421,267; 81,267; and 38.6 µg/µL. The highest proteolytic activity test was in sample 2 of 2.13.
Uji Aktivitas SOD (Superoxide Dismutase) Bakteri Limbah Cair Tahu dengan Metode WST-1 (Water Soluble Tetrazolium Salt-1) dan Identifikasi Molekuler Bakteri Menggunakan PCR 16S rDNA Pinesti, Arum; Indrayati, Ana; Cahyo, Lukito Mindi
Jurnal Farmasi Udayana Vol. 12, No. 2, tahun 2023
Publisher : Departement of Pharmacy, Faculty of Mathematics and Natural Science, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/JFU.2023.v12.i02.p03

Abstract

Abstrak-Superoksida dismutase (SOD) merupakan enzim antioksidan endogen yang dapat dihasilkan oleh beberapa mikroorganisme seperti bakteri yang digunakan untuk menetralisir radikal bebas. Tujuan penelitian ini adalah isolasi dan identifikasi bakteri penghasil SOD dari limbah cair tahu, menguji aktivitas SOD dan identifikasi molekuler dengan PCR 16S rDNA bakteri yang memiliki aktivitas SOD tertinggi. Tahapan penelitian meliputi: isolasi bakteri dari limbah cair tahu menggunakan media NA. Lima isolat bakteri dipilih dan diidentifikasi berdasarkan perbedaan morfologi. Tahap selanjutnya ekstraksi SOD, penetapan kadar protein dengan BCA Assay dan uji aktivitas menggunakan WST-1 Assay Kit. Bakteri dengan aktivitas SOD tertinggi didentifikasi molekuler menggunakan PCR 16S rDNA. Lima isolat bakteri berhasil diisolasi. LCT 1, 2 dan 3 termasuk Gram positif sedangkan LCT 4 dan 5 termasuk Gram negatif. Ekstraksi enzim dilakukan pada kelima isolat lalu dipresipitasi dengan amonium sulfat 80%. Isolat LCT 5 memiliki aktivitas SOD tertinggi yaitu 87,90%. Hasil identifikasi PCR 16S rDNA adalah Pseudomonas aeruginosa strain HSS-6.
Evaluasi Penggunaan Ramipril dan Candesartan pada Pasien Rawat Inap COVID-19 dengan Komorbid Hipertensi di RSUD Dr. Moewardi Azizah, Deva Yolanda Dwi Nur; Wijayanti, Tri; Cahyo, Lukito Mindi
Jurnal Kefarmasian Indonesia VOLUME 13, NOMOR 1, FEBRUARI 2023
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v13i1.6064

Abstract

Hypertension is the most common comorbid in patients infected by COVID-19. Drugs often given for the treatment of hypertension, namely ramipril, and candesartan, are thought to increase the development of COVID-19 because the angiotensin-converting enzyme inhibitors (ACEI) and angiotensin receptor blockers (ARBs) increase the expression of ACE-2, which is the binding site of SARS-CoV-2. This study aims to analyze the effect of using ramipril and candesartan on healing in hospitalized patients with COVID-19 with hypertension at RSUD dr. Moewardi in 2020. This study was conducted retrospectively. The results were presented descriptively and used medical record data of hospitalized patients with COVID-19 with comorbid hypertension at RSUD dr. Moewardi in 2020. Using ramipril and candesartan affects patient recovery in terms of length of stay (LOS), symptom relief, and RT-PCR test results. Analysis of the research data using SPSS with Spearman correlation test. The Spearman correlation test showed that there was a fairly strong relationship between the use of ramipril and candesartan in patients with COVID-19 with comorbid hypertension on LOS, symptom relief, and RT-PCR test results. The study results show that using ramipril and candesartan can improve the recovery of patients with COVID-19 with comorbid hypertension. ACEI and ARB drugs have not been proven to worsen the patient's condition so their use can be continued.
Inventory Control of Medicine with Minimum-Maximum Stock Level at Ibu Fatmawati Soekarno Hospital Surakarta in 2023 Anwar, Alifia Auriel; Cahyo, Lukito Mindi; Wijayanti, Tri
JURNAL MANAJEMEN DAN PELAYANAN FARMASI (Journal of Management and Pharmacy Practice) Vol 15, No 3
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jmpf.98812

Abstract

Background: Inventory control prevents overstock and stockouts by monitoring availability, usage, while managing loss, damage, and expiration. Many hospitals struggle to manage inventory efficiently. Therefore, it is crucial to categorize drug supplies based on usage and investment values to balance supply and demand.Objectives: The study aims to categorize drug supplies based on their usage and investment values and then calculate the minimum and maximum stocks.Methods: This is a descriptive non-experimental study using cross-sectional data collected descriptively and retrospectively. Secondary data was used from drug information on SIM in 2023 and primary data from interviews. The results will be categorized using ABC categories, and inventory will be managed using the MMSL method. Additionally, the study will calculate the minimum and maximum stock as part of the investment process.Results: The ABC analysis of usage shows the percentage of drug items in groups A consists of 8.17% of items accounting for 70.06% of total usage, group B with 12.03% accounting for 20.41%, and group C with 79.80% accounting for 9.53%. Similarly, for investment value, group A accounts for 70.35%, group B for 20.16%, and group C for 9.50%. The MMSL method resulted in optimal safe, minimum, and maximum stock levels for each drug item.Conclusion: Grouping drugs into A, B, and C categories based on usage value and investment value can help to prioritize a drug, and inventory control with the MMSL method has a positive impact where there is a decrease in the number of purchases and purchase costs after the MMSL method.
Analisis Rasionalitas Penggunaan Obat Antihipertensi Pada Pasien Geriatri di Rumah Sakit X Periode Tahun 2023 Mukti, Gabriella; Harsono, Samuel Budi; Cahyo, Lukito Mindi
Jurnal Mandala Pharmacon Indonesia Vol. 10 No. 2 (2024): Jurnal Mandala Pharmacon Indonesia
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v10i2.558

Abstract

Hipertensi terjadi apabila seseorang mempunyai tekanan darah diatas 140/90 mmHg. Seseorang berusia ? 45 tahun memiliki resiko terkena hipertensi 8,4 kali lebih besar dibanding dengan usia ? 45 tahun. Tujuan penelitian ialah mengetahui rasionalitas obat antihipertensi pada kelompok geriatri di Instalasi Rawat Inap Rumah Sakit X tahun 2023 mengacu pada indikator tepat indikasi obat, tepat kondisi pasien, tepat pemilihan obat, dan tepat dosis. Penelitian menggunakan rancangan pendekatan cross sectional dengan melihat data rekam medik pasien hipertensi kelompok usia geriatri di Instalasi Rawat Inap Rumah Sakit X periode 2023 melalui teknik purposive sampling. Analisis hasil yang dilakukan mempertimbangkan pemakaian obat pada pedoman yang telah ditetapkan. Menurut penelitian, golongan CCB merupakan antihipertensi yang paling banyak digunakan. Kriteria JNC 8 digunakan sebagai standar pembanding pada data penelitian yang didapatkan. Pada penelitian ini ditemukan kesesuaian tepat dosis serta tepat indikasi obat sebesar 100%, tepat kondisi pasien sebesar 93,75%, dan tepat pemilihan obat sebesar 92,5%. Berdasarkan uji statistik chi?square ada korelasi yang signifikan antara rasionalitas penggunaan obat antihipertensi dengan outcome klinis pasien hipertensi usia geriatri di Rumah Sakit X.
Co-Authors Ana Indrayati Anwar, Alifia Auriel Avianti Dewi Purwaningsih Azizah, Deva Yolanda Dwi Nur Deva Yolanda Dwi Nur Azizah Ghani Nurfiana Fadma Sari Harsono, Samuel Budi Masyitah Novia Mukti, Gabriella Pinesti, Arum Tri Wijayanti Tri Wijayanti Wiwi Kusumasari