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All Journal ARSHI Veterinary Letters Current Biomedicine
Agustin Indrawati
Division of Medical Microbiology, School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Public Health Veterinary

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Detection of quinolone antibiotic resistance genes in Escherichia coli isolated from dairy cattle feces Muhammad Ammar Raihan; Sara Elsharkawy; Agustin Indrawati; Hadri Latif
Current Biomedicine Vol. 4 No. 1 (2026): January
Publisher : School of Veterinary Medicine and Biomedical Sciences, IPB University, Bogor, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/currbiomed.4.1.1

Abstract

Background Livestock raised in densely populated areas can serve as reservoirs for bacteria such as Escherichia coli, which may harbor antibiotic resistance genes that threaten both animal and human health. Objective This study aimed to identify and characterize quinolone resistance genes in E. coli isolated from dairy cattle feces. Methods Fifteen E. coli isolates were obtained from 15 dairy farms located in Kebon Pedes, Bogor, West Java. Genotypic detection of quinolone resistance genes was conducted using DNA sequencing on the MinION platform. Results All E. coli isolates (100%) carried at least one quinolone resistance gene. Of these, ten isolates (67%) contained a single resistance gene, while five isolates (33%) possessed two genes. The qnrS1_1 gene was identified in all isolates and represented the predominant genotype, whereas the qnrVC4_1 gene was found in five isolates (33%), mostly co-occurring with qnrS1_1. Both genes are plasmid-mediated and categorized as plasmid-mediated quinolone resistance (PMQR) genes. Conclusion The detection of qnrS1_1 and qnrVC4_1 genes in E. coli isolated from dairy cattle feces indicates that livestock manure may act as a reservoir for quinolone resistance genes, contributing to their persistence and potential spread within farm environments.
Evaluasi antidiare infus daun jambu biji pada tikus pediatrik menggunakan model transit usus Altaff Hendry; Teo Qin Yan; Daniel Latief Andre; Muhammad Luthfi Rahman; Win Satya Rudramurti; Nadine Hanifa Permana; Dian Maulia Utami; Diah Nugrahani Pristihadi; Agustin Indrawati
ARSHI Veterinary Letters Vol. 9 No. 4 (2025): ARSHI Veterinary Letters - November 2025
Publisher : School of Veterinary Medicine and Biomedical Sciences, Bogor Agricultural University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/avl.9.4.119-120

Abstract

Diare merupakan gangguan gastrointestinal utama pada anak-anak dan masih menjadi penyebab kematian yang signifikan, terutama pada balita. Daun jambu biji (Psidium guajava L.) telah lama digunakan dalam pengobatan tradisional sebagai obat antidiare. Penelitian ini bertujuan untuk menentukan dosis efektif infusa daun jambu biji pada tikus yang disapih menggunakan metode transit intestinal. Tiga puluh tikus sehat secara acak dibagi menjadi enam kelompok: kontrol negatif (air suling), kontrol positif (atropin sulfat 2,5 mg/kg BB), dan empat kelompok perlakuan yang menerima infusa daun jambu biji dengan dosis 100, 200, 400, dan 800 mg/kg BB. Di antara kelompok perlakuan, dosis 200 mg/kg BB menghasilkan penurunan transit intestinal terbesar. Namun, tidak ada perbedaan yang signifikan secara statistik yang diamati antara kelompok perlakuan dan kontrol negatif. Hasil ini menunjukkan bahwa dalam rentang dosis yang diperiksa, infusa daun jambu biji tidak menunjukkan efek antidiare yang signifikan pada model tikus pediatrik.
Co-Authors Altaff Hendry Daniel Latief Andre Diah Nugrahani Pristihadi Dian Maulia Utami Hadri Latif Muhammad Ammar Raihan Muhammad Luthfi Rahman Nadine Hanifa Permana Sara Elsharkawy Teo Qin Yan Win Satya Rudramurti