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All Journal Eureka Herba Indonesia Sriwijaya Journal of Otorhinolaryngology
Oliva Azalia Putri
Department of Thoracic Surgery, CMHC Research Center, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Curcumin-Loaded Solid Lipid Nanoparticles from Curcuma longa Attenuate Inflammatory Cytokine Cascades in a Rat Model of Acute Peritonitis Oliva Azalia Putri; Dedi Sucipto
Eureka Herba Indonesia Vol. 6 No. 1 (2025): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v6i1.137

Abstract

Acute peritonitis remains a life-threatening intra-abdominal inflammatory condition with significant morbidity and mortality, particularly in resource-limited settings across Southeast Asia. Curcumin, the principal polyphenol of Curcuma longa L. (Zingiberaceae), has potent anti-inflammatory and antioxidant properties, but its clinical use is limited by poor oral bioavailability, rapid hepatic metabolism, and low aqueous solubility. This study evaluated the anti-inflammatory and antioxidant efficacy of curcumin-loaded solid lipid nanoparticles (Cur-SLNs) in a cecal ligation and puncture (CLP)-induced acute peritonitis rat model. Thirty male Wistar rats were randomized into five groups (n=6): sham, CLP+vehicle, CLP+free curcumin (100 mg/kg), CLP+Cur-SLN low dose (50 mg/kg), and CLP+Cur-SLN high dose (100 mg/kg). Cur-SLNs prepared by hot homogenization-ultrasonication had a mean particle size of 152.4±8.7 nm, polydispersity index 0.218±0.03, zeta potential −28.6±2.1 mV, and entrapment efficiency 87.3±3.2%. At 24 hours, Cur-SLN high dose significantly reduced TNF-α (89.6±18.3 versus 287.5±45.2 pg/mL, p<0.001), IL-6 (102.4±22.7 versus 312.4±52.8 pg/mL, p<0.001), and IL-1β (78.5±16.8 versus 245.6±41.3 pg/mL, p<0.001) compared with CLP-vehicle, with large effect sizes (Cohen's d 4.50–5.72), alongside attenuated oxidative stress, reduced bacterial burden, and preserved peritoneal histology. Cur-SLNs from Curcuma longa represent a promising herbal nanomedicine strategy for attenuating inflammatory cascades in acute peritonitis.
Comparative Efficacy of Topical Antifungal and Antiseptic Agents for Otomycosis in Tropical and Subtropical Climates: A Systematic Review and Meta-Analysis Rachmat Hidayat; Oliva Azalia Putri; Aisyah Andina Rasyid
Sriwijaya Journal of Otorhinolaryngology Vol. 3 No. 2 (2025): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v3i2.305

Abstract

Background: Otomycosis is a superficial fungal infection of the external auditory canal that is disproportionately prevalent in tropical and subtropical regions, yet the comparative efficacy of topical agents in this climatic and mycological context has not been quantitatively synthesised. Objective: To compare complete-cure rates of topical antifungal and antiseptic agents for otomycosis using comparative studies from tropical and subtropical countries. Methods: Following a registered protocol (PROSPERO CRD420261456091) and PRISMA 2020, we identified comparative studies reporting complete cure or mycological eradication. Ten studies (1,970 ears; eight countries) were included. The pre-specified primary comparison, povidone-iodine versus clotrimazole, was pooled as a risk ratio (RR) using a random-effects model with the Hartung–Knapp–Sidik–Jonkman correction, a 95% prediction interval and a leave-one-out analysis. Risk of bias used RoB 2 and ROBINS-I; certainty used GRADE. Results: The random-effects pooled cure rate across 21 arms was 74.9% (95% CI 66.9–82.2; I² = 93%). For povidone-iodine versus clotrimazole (k = 4), the pooled RR was 0.86 (HKSJ 95% CI 0.53–1.39; prediction interval 0.29–2.58), indicating no significant difference while excluding neither agent's superiority. Between-study heterogeneity (I² = 79%) arose entirely from one non-randomised study; omitting it gave RR 0.95 (0.85–1.06) with I² = 0%. Certainty was low to very low. Conclusion: Topical azoles and low-cost antiseptics such as povidone-iodine achieve broadly similar, moderate cure rates for otomycosis in tropical settings, but the evidence is too imprecise to establish equivalence, and potential ototoxicity means agent choice should remain individualised.
Co-Authors Aisyah Andina Rasyid Dedi Sucipto RACHMAT HIDAYAT