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All Journal Eureka Herba Indonesia Sriwijaya Journal of Forensic and Medicolegal Sriwijaya Journal of Internal Medicine Sriwijaya Journal of Otorhinolaryngology
Aisyah Andina Rasyid
Department of Otorhinolaryngology, CMHC Research Center, Palembang, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Neuroscience Nursing Public Health

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Comparative Efficacy of Topical Antifungal and Antiseptic Agents for Otomycosis in Tropical and Subtropical Climates: A Systematic Review and Meta-Analysis Rachmat Hidayat; Oliva Azalia Putri; Aisyah Andina Rasyid
Sriwijaya Journal of Otorhinolaryngology Vol. 3 No. 2 (2025): Sriwijaya Journal of Otorhinolaryngology
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjorl.v3i2.305

Abstract

Background: Otomycosis is a superficial fungal infection of the external auditory canal that is disproportionately prevalent in tropical and subtropical regions, yet the comparative efficacy of topical agents in this climatic and mycological context has not been quantitatively synthesised. Objective: To compare complete-cure rates of topical antifungal and antiseptic agents for otomycosis using comparative studies from tropical and subtropical countries. Methods: Following a registered protocol (PROSPERO CRD420261456091) and PRISMA 2020, we identified comparative studies reporting complete cure or mycological eradication. Ten studies (1,970 ears; eight countries) were included. The pre-specified primary comparison, povidone-iodine versus clotrimazole, was pooled as a risk ratio (RR) using a random-effects model with the Hartung–Knapp–Sidik–Jonkman correction, a 95% prediction interval and a leave-one-out analysis. Risk of bias used RoB 2 and ROBINS-I; certainty used GRADE. Results: The random-effects pooled cure rate across 21 arms was 74.9% (95% CI 66.9–82.2; I² = 93%). For povidone-iodine versus clotrimazole (k = 4), the pooled RR was 0.86 (HKSJ 95% CI 0.53–1.39; prediction interval 0.29–2.58), indicating no significant difference while excluding neither agent's superiority. Between-study heterogeneity (I² = 79%) arose entirely from one non-randomised study; omitting it gave RR 0.95 (0.85–1.06) with I² = 0%. Certainty was low to very low. Conclusion: Topical azoles and low-cost antiseptics such as povidone-iodine achieve broadly similar, moderate cure rates for otomycosis in tropical settings, but the evidence is too imprecise to establish equivalence, and potential ototoxicity means agent choice should remain individualised.
Failure to Palpate and Failure to Image: Quantifying Standard-of-Care Departure in Fatal Delayed Intracranial Foreign Body Diagnosis, Indonesia Aisyah Andina Rasyid; Priscilla Kapoor; Febria Suryani
Sriwijaya Journal of Forensic and Medicolegal Vol. 3 No. 2 (2025): Sriwijaya Journal of Forensic and Medicolegal
Publisher : Phlox Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjfm.v3i2.247

Abstract

Background. Retained intracranial foreign bodies in patients alert at a Glasgow Coma Scale (GCS) of 15 are a rare, lethal and medicolegally exposed failure in Indonesian assault casework, yet the share attributable to specific documentable procedural omissions is unquantified. Objective. To quantify the association of failure to palpate the wound bed and non-adherence to computed tomography (CT) guidelines with delayed diagnosis, and to derive medicolegal attribution metrics. Methods. This retrospective multi-centre cohort (STROBE) examined 45 confirmed retained intracranial foreign bodies among 1,240 mild traumatic brain injury presentations (prevalence 3.63%, 95% CI 2.72–4.82) at three North Sumatran trauma centres, 2019–2023. Diagnosis beyond 24 hours was the pre-specified outcome. Analysis of aggregate data used exact conditional and Firth-penalised odds ratios, Holm multiplicity control, and partial identification of the multivariable model across 4,000 admissible joint arrangements. Results. Diagnosis was delayed in 14 of 45 cases (31.1%, 95% CI 19.5–45.7). Failure to palpate the wound bed carried an exact conditional odds ratio of 29.86 (4.79–281.0; p < 0.001) and CT non-adherence 20.88 (3.57–174.7; p < 0.001). Palpation failure achieved sensitivity 78.6%, specificity 90.3% and area under the curve 0.844; the attributable fraction was 76.3% (50.8–96.1). Adjusted odds ratios were bounded, not estimated, because aggregate data cannot identify a multivariable model. Conclusion. Two zero-cost omissions dominate a fatal diagnostic failure; recording wound-bed palpation and the imaging decision is clinically protective and, under KUHAP Articles 133 and 179 and Law No. 17 of 2023, is what a visum et repertum requires.
The Impact of Uncontrolled Type 2 Diabetes Mellitus on Chronic Rhinosinusitis Severity and Treatment Outcomes: A Prospective Cohort Study in Bandung, Indonesia Zainal Abidin Hasan; Aisyah Andina Rasyid; Hasrita Soleiman; Alexander Mulya; Pham Uyen; Maria Rodriguez
Sriwijaya Journal of Internal Medicine Vol. 3 No. 1 (2025): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i2.176

Abstract

Introduction: Chronic rhinosinusitis (CRS) is a prevalent inflammatory condition, and type 2 diabetes mellitus (T2DM) is a known comorbidity that can exacerbate inflammatory processes. This study aimed to investigate the impact of uncontrolled T2DM on CRS severity and treatment outcomes in a cohort of patients in Bandung, Indonesia. Methods: A prospective cohort study was conducted at a private hospital in Bandung, Indonesia, from January 2020 to December 2022. Adult patients diagnosed with CRS (with or without nasal polyps) were enrolled and categorized into two groups: controlled T2DM (HbA1c ≤ 7%) and uncontrolled T2DM (HbA1c > 7%). CRS severity was assessed using the Sino-Nasal Outcome Test-22 (SNOT-22) and Lund-Mackay CT scoring. Treatment outcomes were evaluated at 3, 6, and 12 months post-initial treatment (medical and/or surgical) based on SNOT-22 scores, endoscopic findings, and the need for revision surgery. Results: A total of 240 patients were included (120 with controlled T2DM, 120 with uncontrolled T2DM). At baseline, the uncontrolled T2DM group had significantly higher mean SNOT-22 scores (58.5 ± 12.3 vs. 45.2 ± 10.1, p < 0.001) and Lund-Mackay CT scores (11.8 ± 3.5 vs. 8.2 ± 2.8, p < 0.001) compared to the controlled T2DM group. At 12 months, the uncontrolled T2DM group showed significantly less improvement in SNOT-22 scores (mean change: -15.4 ± 8.7 vs. -28.3 ± 9.2, p < 0.001) and a higher rate of revision surgery (18.3% vs. 5.8%, p = 0.002). Multivariate analysis revealed that uncontrolled T2DM (HbA1c > 7%) was an independent predictor of poorer treatment outcomes (OR: 3.45, 95% CI: 1.98-6.01, p < 0.001). Conclusion: Uncontrolled T2DM is associated with increased CRS severity and significantly poorer treatment outcomes in patients in Bandung, Indonesia. Effective glycemic control should be a crucial component of CRS management in patients with T2DM.
Antibiofilm and Microbiome-Modulatory Effects of Syzygium aromaticum Essential Oil in an In Vitro Dental Caries Polymicrobial Model Syaifudin Syaifudin; Aisyah Andina Rasyid; Johan Wirahadi Putro
Eureka Herba Indonesia Vol. 7 No. 2 (2026): Eureka Herba Indonesia
Publisher : HM Publisher in collaboration with CMHC Research Center

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v7i2.147

Abstract

Background: Dental caries is a microbiome-driven disease in which acidogenic taxa dominated by Streptococcus mutans displace commensal genera and form a glucan-rich biofilm matrix that demineralises enamel. Chlorhexidine (CHX) is the standard chemical adjunct but causes staining, dysgeusia and broad commensal suppression, motivating evaluation of botanical alternatives that may rebalance the oral ecosystem. Objective: To determine the antibiofilm and microbiome-modulatory effects of standardised Indonesian Syzygium aromaticum L. (clove, Myrtaceae) bud essential oil (SAEO) on saliva-derived polymicrobial cariogenic biofilms in vitro. Methods: SAEO was hydrodistilled, characterised by gas chromatography–mass spectrometry (GC-MS), and tested at SAEO 0.25%, 0.5% and 1.0% v/v against polymicrobial biofilms grown on hydroxyapatite discs from stimulated saliva of 60 caries-active adults; CHX 0.12% was the positive control (n = 6 per arm). Endpoints were biofilm biomass, colony-forming units (CFU) on selective media, extracellular polymeric substance (EPS), biofilm pH, lactate, 16S rRNA microbiome profiling and human gingival fibroblast (HGF-1) cytotoxicity. Results: Eugenol (82.3%), β-caryophyllene (7.4%) and eugenyl acetate (4.8%) were the principal volatiles. SAEO 1.0% reduced biofilm biomass by 70.5% (95% CI 65.8–75.3; p < 0.001), S. mutans CFU by 3.22 log10 and EPS by 67.9%, while raising Shannon diversity from 1.42 to 2.08 bits and restoring Neisseria and Corynebacterium relative abundance — a dysbiosis-reversal pattern absent under CHX. Cytotoxicity reached 17.6% at SAEO 1.0% versus 31.8% for CHX 0.12%. Conclusion: Standardised SAEO is a credible complementary anticaries agent meriting clinical translation.
Co-Authors Alexander Mulya Febria Suryani Hasrita Soleiman Johan Wirahadi Putro Maria Rodriguez Oliva Azalia Putri Pham Uyen Priscilla Kapoor RACHMAT HIDAYAT Syaifudin Syaifudin Zainal Abidin Hasan