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All Journal Jurnal Kesehatan Ilmiah Indonesia / Indonesian Health Scientific Journal Indonesian Journal of Health Sciences Research and Development (IJHSRD) JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL
Havida Widyastuti
Universitas Aisyiyah Yogyakarta
Education Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Efek Terapi Ekstrak Kulit Buah Naga Merah Terhadap Kadar MDA Hati, SGOT dan SGPT Pada Tikus Putih yang Diinduksi Boraks Havida Widyastuti; Rosmita Anggraeni
Jurnal Kesehatan Ilmiah Aufa Royhan Vol 11 No 1 (2026): Vol. 11 No. 1 Juni 2026
Publisher : Universitas Aufa Royhan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51933/health.v11i1.2684

Abstract

Boraks merupakan zat toksik berbahaya, ketika masuk ke dalam tubuh maka terbentuk radikal bebas yang menyebabkan stress oksidatif. Kulit buah naga merah memiliki kandungan senyawa seperti flavonoid, alkaloid, tanin dan saponin yang dapat menurunkan stress oksidatif. Penelitian ini dilakukan untuk mengetahui efek terapi ekstrak kulit buah naga merah terhadap kadar MDA hati, SGOT dan SGPT darah tikus yang diinduksi boraks sebesar 20 mg/kg BB. Penelitian ini menggunakan empat kelompok uji yaitu kontrol negatif dan tiga kelompok perlakuan dengan pemberian ekstrak kulit buah naga merah dosis 0,5; 1,0 dan 2,0 g/kg BB selama 7 hari. Analisis data menggunakan uji One Way ANOVA dan Uji Post Hoc. Hasil penelitian menunjukkan pada pemeriksaan MDA hati dan SGPT terjadi penurunan signifikan (p<0,05) terhadap kontrol pada kelompok perlakuan 2 dan 3. Penurunan signifikan kadar SGOT terhadap kelompok kontrol terjadi pada semua kelompok perlakuan. Pada perlakuan 1 kadar SGOT dan SGPT masih berada diatas nilai normal meskipun telah diberi terapi ekstrak kulit buah naga. Dosis terbaik pemberian ekstrak kulit buah naga yang mampu menurunkan kadar MDA hati, SGOT dan SGPT yaitu dosis 2 g/kg BB. Untuk penelitian selanjutnya dapat dilakukan analisis terhadap profil hematologi atau parameter fungsi ginjal sebagai biomarka pendukung lainnya
THE LIVER FUNCTION TEST (TRANSAMINASE ENZYMES AND BILIRUBIN) AND THE KIDNEY FUNCTION TESTS (UREA, CREATININE) ANALYSIS IN MDR-TB DURING TREATMENT Widaninggar Rahma Putri; Havida Widyastuti; Dhini Intan Cahyani; Wa Ode Hikma Fajar
INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT (IJHSRD) Vol. 8 No. 1 (2026): INDONESIAN JOURNAL OF HEALTH SCIENCES RESEARCH AND DEVELOPMENT
Publisher : STIKes Mandala Waluya Kendari

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36566/ijhsrd/Vol8.Iss1/370

Abstract

Background: Multi Drug Resistance Tuberculosis (MDR-TB) treatment caused side effects such as hepatotoxicity and acute kidney injury (AKI).  Monitoring liver and kidney function in patients during treatment is crucial to prevent complication. Methods: A retrospective study of 19 patients confirmed MDR-TB in the period 2022-2025. Liver function test (transaminase enzymes and bilirubin) and kidney function test (urea and creatinine) during the first three month of treatment were analyzed. Results: Statistically, there was no difference in all parameters (p>0.05). Increases in total bilirubin, SGOT, SGPT levels occurred in the third month of TB treatment. While urea and creatinine levels increased in the second and third months. Conclusion: Monitoring of liver and kidney function during MDR-TB treatment is necessary to monitor patient condition.
Perbandingan Kadar HbA1c Pasien DM Tipe 2 Terapi Insulin dan Non Insulin di RS PKU Muhammadiyah Gamping Periode 2025 Lutfiah Sungkar; Joko Murdiyanto; Havida Widyastuti
JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL Vol. 4 No. 3 (2026): Agustus : JURNAL ILMIAH KESEHATAN MASYARAKAT DAN SOSIAL
Publisher : CV. ALIM'SPUBLISHING

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59024/jikas.v4i3.1892

Abstract

Type 2 diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia due to impaired insulin secretion, insulin resistance, or a combination of both. HbA1c levels are used as an indicator of long-term glycemic control in patients with type 2 diabetes mellitus. Insulin therapy is one of the treatment options given to help achieve glycemic control targets. The purpose of this study was to determine the difference in HbA1c levels of type 2 diabetes mellitus patients with insulin and non-insulin therapy at PKU Muhammadiyah Gamping Hospital. This research method used a descriptive study with a cross-sectional approach. The subjects in this study were 80 type 2 diabetes mellitus patients who had used insulin and non-insulin therapy for less than 1 year, using Purposive Sampling techniques and data analysis using SPSS with Chi-Square and Mann-Whitney tests. This study has obtained ethical approval from PKU Muhammadiyah Gamping Hospital. This study shows that the characteristics of gender and age of type 2 DM patients with insulin and non-insulin therapy are dominated by women at 60.0% and 43.3%, while elderly patients at 60.0% and 53.3%. Of the 50 patients using insulin, 45 patients (90.0%) had controlled HbA1c and 5 patients (10.0%) were uncontrolled. Meanwhile, all non-insulin patients, 30 patients (100%), had uncontrolled HbA1c. Based on this study, there is a significant difference in HbA1c levels between type 2 diabetes mellitus patients with insulin and non-insulin therapy with a p-value <0.001. Patients using insulin therapy tend to have better glycemic control than patients not using insulin therapy.
Co-Authors Dhini Intan Cahyani Joko Murdiyanto Lutfiah Sungkar Rosmita Anggraeni Wa Ode Hikma Fajar Widaninggar Rahma Putri