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All Journal Jurnal Analis Medika Biosains (JAMBS) Medfarm: Jurnal Farmasi dan Kesehatan
Siska Zafrida
Akademi Kesehatan John Paul II Pekanbaru
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology Public Health

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Thrombolytic Activity Test of Spider Plant Leaf Extract (Chlorophytum Spp.) Siska Zafrida; Hartini H; Ignatius Yulianto; Melsa kharunnisa
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 15 No 1 (2026): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v15i1.756

Abstract

Cardiovascular disease (CVD) is a disorder of the heart and blood vessels and remains the leading cause of death worldwide. Atherosclerosis and thrombosis are major contributors to CVD. Thrombolytic agents such as urokinase, streptokinase, and nattokinase are effective in dissolving blood clots; however, their prolonged use may cause adverse effects and high treatment costs. Therefore, the development of safer and more affordable natural thrombolytic agents is necessary. This study aimed to evaluate the in vitro thrombolytic activity of ethanol extract from spider plant leaves (Chlorophytum spp.). The study employed a post-test only control group experimental design using extract concentrations of 0.5%, 1%, and 2%, with nattokinase as the positive control and distilled water as the negative control. Phytochemical screening revealed the presence of flavonoids, saponins, and tannins in the extract. The thrombolytic activity increased with increasing extract concentration. The ethanol extract demonstrated clot lysis percentages of 2.8%, 4.2%, and 5.5% at concentrations of 0.5%, 1%, and 2%, respectively. Although its thrombolytic activity was lower than that of the positive control, the extract showed concentration-dependent thrombolytic potential. These findings suggest that spider plant (Chlorophytum spp.) leaves possess bioactive compounds with thrombolytic properties and may serve as a promising natural source for the development of alternative thrombolytic agents. Further studies, including isolation of active compounds and in vivo evaluation, are recommended.
Overview of Platelet Counts Before and After Platelet-Rich Plasma (PRP) Preparation Aisyara Yuliandari; Izah Mahrani; Siska Zafrida; Hartini Hartini; Fauzan Fauzan
Jurnal Analis Medika Biosains (JAMBS) Vol. 13 No. 01 (2026): JURNAL ANALIS MEDIKA BIOSAINS (JAMBS)
Publisher : Poltekkes Kemenkes Mataram

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Abstract

Platelet-Rich Plasma (PRP) is widely utilized in various clinical settings for tissue repair, particularly in skin rejuvenation, scar management, and wound healing. This study aimed to evaluate the profile of platelet counts both prior to and following the PRP preparation process. Whole blood samples were collected from eligible female participants and platelet levels analyzed using a hematology analyzer. The findings revealed a four-fold rise in the mean platelet count, increasing from a baseline of 190.6×103 cells/µL to 781.1×103 cells/μL after preparation. The study concluded that baseline platelet levels in whole blood are directly proportional to the final platelet concentration in PRP.
Co-Authors Aisyara Yuliandari Fauzan Fauzan Hartini H Hartini Hartini Ignatius Yulianto Izah Mahrani Melsa kharunnisa