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All Journal Jurnal Riset Sains dan Kimia Terapan Jurnal Penelitian Teknologi Informasi dan Sains
Citra Santikasari
Universitas Negeri Jakarta
Chemistry Computer Science & IT

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Identification and Assay of Isoniazid and Pyrazinamide in Fixed-Dose Dispersible Tablets Containing Rifampicin Using High-Performance Liquid Chromatography Citra Santikasari; Meyliana Wulandari; Shofi Nafisa Ulfa; Mirawati Siregar; Syed Azhar Syed Sulaiman
Jurnal Riset Sains dan Kimia Terapan Vol. 11 No. 2 (2025): Jurnal Riset Sains dan Kimia Terapan, Volume 11 Nomor 2, Desember 2025
Publisher : Program Studi Kimia Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21009/JRSKT.112.04

Abstract

Tuberculosis (TB) remains a major global health challenge, particularly in Indonesia, which ranks among the countries withthe highest TB burden. Fixed-dose dispersible anti-tuberculosis formulations containing rifampicin, isoniazid, and pyrazinamide are widely recommended to enhance patient adherence and minimize the risk of drug resistance. Ensuring the quality and appropriate dosage of active pharmaceutical ingredients is essential for achieving therapeutic effectiveness and maintaining TB control. This study aimed to perform routine quality assessment and regulatory compliance assays on commercialanti-TB fixed-dose combination (FDC) dispersible tablets using a reversed-phase high-performance liquid chromatography (HPLC) method as specified in the International Pharmacopoeia 2025. The HPLC system was equipped with a C18 column and used a mobile phase consisting of acetate buffer (pH 5) and methanol (94:6 v/v). System suitability testing was conducted before analysis, with %RSD values below 2%, resolution greaterthan 2.0, and tailing factors ≤ 2.0, indicating acceptable precision, selectivity, and chromatographic performance. The retention times of isoniazid and pyrazinamide were consistent with those of the reference standards, confirming identity. The assay results showed that pyrazinamide (100.3%) and isoniazid (99.9%) were within the specification limits set by the International Pharmacopoeia. These findings demonstrate that the official monograph method is suitable for regulatory-grade quality control testing of dispersible anti-tuberculosis fixed-dose combination tablets, and that the tested product met pharmacopeial quality requirements.
Penerapan Mini Cooler Berbasis Minyak Kelapa dan Beeswax Sebagai Media Pembelajaran untuk Penguatan Literasi Sains Siswa SMA Neng Tresna Umi Culsum; Rinda Mulmeyda; Citra Santikasari; Roni Adi Wijaya; Ika Keumala Fitri; Key Yodiananda Divia; Nadine Davina Nawing; Cut Gianna Naifa Dharmawan; Ni Putu Ryane Pinajeng; Meta Arishanti
Jurnal Penelitian Teknologi Informasi dan Sains Vol. 4 No. 1 (2026): : JURNAL PENELITIAN TEKNOLOGI INFORMASI DAN SAINS (JPTIS)
Publisher : Institut Teknologi dan Bisnis (ITB) Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54066/jptis.v4i1.5057

Abstract

Scientific literacy among high school students needs to be strengthened through contextual and experiential learning that connects scientific concepts with their applications in everyday life. This community service program aimed to support teachers in developing experiment-based learning activities to enhance students’ scientific literacy through the utilization of coconut oil and beeswax as thermal energy storage materials. The activities consisted of scientific material delivery, experiments involving coconut oil and beeswax, assembly of a simple mini cooler prototype, and observation and temperature measurement. The results showed that participants' understanding of phase change and energy concepts improved, with an average post-test score of 98.75; furthermore, participants successfully produced a mini cooler prototype based on coconut oil and beeswax. The prototype can be utilized as a learning medium to introduce phase changes, heat transfer, and thermal energy storage concepts. The activity also provided teachers with an applicable approach to designing experimental learning that encourages students to observe phenomena, interpret experimental data, and apply scientific concepts to real-life situations. This program demonstrates the potential of locally available materials and simple experimental technology to support the development of innovative science learning and strengthen scientific literacy among high school students.
Co-Authors Cut Gianna Naifa Dharmawan Ika Keumala Fitri Key Yodiananda Divia Meta Arishanti Meyliana Wulandari Mirawati Siregar Nadine Davina Nawing Neng Tresna Umi Culsum Ni Putu Ryane Pinajeng Rinda Mulmeyda Roni Adi Wijaya Shofi Nafisa Ulfa Syed Azhar Syed Sulaiman