The present study was conducted in response to the low learning outcomes of students in understanding Pancasila Education content, particularly in applying Pancasila values in everyday life. This problem was related to the use of learning media that were still limited and less engaging, as well as learning activities that tended to be conventional. One way to improve students’ understanding is through the use of interesting, contextual learning media supported by Artificial Intelligence, such as CTL-based e-comics. This study aimed to develop an e-comic, identify its validity, and examine students’ knowledge acquisition outcomes after using the developed e-comic. This research adopted the Research and Development (R&D) method based on the ADDIE framework. The study involved 20 fourth-grade students of SD Negeri 23 Lubuklinggau as research participants. The findings indicated that the developed e-comic obtained validity scores of 0.96 from the material expert, 0.85 from the media specialist, and 0.87 from the linguistics specialist, all of which were categorized as highly valid. The practicality test results showed percentages of 94.2% in the individual trial, 91.08% in the small-group trial, and 97.3% in the product trial, which were categorized as highly practical. The pre-test and post-test results indicated an increase in students’ academic performance after using the developed e-comic. The mean N-gain value was 0.52, which was categorized as medium. Based on the results of the study, the AI-assisted CTL-based e-comic developed using Canva is feasible for use in Pancasila Education learning at primary schools.