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All Journal Strada Journal of Pharmacy
Juvita Herdianty
Universitas STRADA Indonesia
Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology

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Formulation and Physical Quality Evaluation of Cyperus rotundus L. Water Fraction Gel Alfara Derista Felany; Juvita Herdianty; Devita Riafinola Andaririt; Ivan Junius Mesak; Bilal Subchan
Strada Journal of Pharmacy Vol. 8 No. 1 (2026): April
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v8i1.202

Abstract

The development of topical preparations from natural ingredients requires rigorous physical quality evaluation to ensure their safety, stability, and efficacy. This study aimed to formulate and evaluate the physical quality of a gel preparation containing the water fraction of Cyperus rotundus L. at various concentrations. The water fraction of the rhizome was formulated into gel preparations with concentrations of 5% (F1), 10% (F2), 15% (F3), and 20% (F4) using Carbopol 940 as a gelling agent. The physical quality evaluation included organoleptic tests, homogeneity, pH, spreadability, adhesion, and viscosity. The results showed that all gel formulas met the established physical quality requirements. An increase in the concentration of the water fraction significantly affected the physical characteristics of the preparation, such as a more intense color, as well as an increase in pH, adhesion, and viscosity. All formulas exhibited a pH suitable for the physiological range of the skin (5.53–6.80), good spreadability (5.49–6.77 cm), and adequate adhesion (>2 seconds). It was concluded that the nut grass rhizome water fraction gel has stable and acceptable physical characteristics, making it a potential candidate for further development as a topical preparation.
Anti-Acne Activity Evaluation Of Cyperus rotundus L. Rhizome Fraction Gel Against Staphylococcus aureus And Propionibacterium acnes Musdalifah Qadariah; Juvita Herdianty; Luluk Aniqoh Meliana Putri; Ardhi Broto Sumanto
Strada Journal of Pharmacy Vol. 7 No. 2 (2025): October
Publisher : Universitas STRADA Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30994/sjp.v7i2.203

Abstract

Acne is an inflammatory skin condition often caused by bacteria such as Propionibacterium acnes and Staphylococcus aureus. The increasing incidence of antibiotic resistance encourages the search for alternatives from natural ingredients. Nut grass rhizome (Cyperus rotundus L.) is known to have antibacterial compounds. This study aimed to formulate a gel from the fractions of nut grass rhizome, test its activity against acne-causing bacteria, and identify the most potent fraction. This study employed a laboratory experimental design. The nut grass rhizome was extracted with 70% ethanol and then fractionated by liquid-liquid partitioning using n-hexane, ethyl acetate, and water as solvents. Each fraction was formulated into a gel at a 5% concentration, and its antibacterial activity was tested using the well diffusion method. All gel formulas met the physical quality evaluation requirements. The ethyl acetate fraction (F2) exhibited the strongest antibacterial activity, with an average inhibition zone of 19.48 ± 0.99 mm (moderate category) against Staphylococcus aureus and 25.86 ± 0.65 mm (strong category) against Propionibacterium acnes. The nut grass rhizome fraction gel preparation possesses anti-acne activity. The ethyl acetate fraction proved to be the most potent, showing efficacy against Propionibacterium acnes (inhibition zone 25.86 mm) that was statistically equivalent to the positive control (p = 0.767).
Co-Authors Alfara Derista Felany Ardhi Broto Sumanto Bilal Subchan Devita Riafinola Ivan Junius Mesak Musdalifah Qadariah Putri, Luluk Aniqoh Meliana