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All Journal Fundamental and Applied Research in Medicine and Allied Sciences Indonesia
Dara Sukma Ratmelya
Universitas Syiah Kuala, Indonesia

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Formulation Study and Evaluation of the Effectiveness of Natural Polymer-Based Dissolving Microneedles for Model Vaccine Delivery Emma Jayanti Besan; Muhammad Nurul Fadel; Nur Masyithah Zamruddin; Dara Sukma Ratmelya; Yuneka Saristiana
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 1 (2026): May, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i1.524

Abstract

Dissolving microneedle (DMN) arrays made from biocompatible natural polymers offer a promising transdermal vaccine delivery system that can reduce pain, eliminate cold-chain dependence, and minimize the need for trained healthcare workers compared to conventional injections. This study aimed to formulate and characterize natural polymer-based DMNs containing ovalbumin (OVA) as a model antigen and evaluate their immunogenicity in mice. DMNs (F1–F5) were prepared using polyvinyl alcohol (PVA), polyvinylpyrrolidone (PVP K30), and hyaluronic acid (HA) at different concentrations through spin-casting into PDMS molds. The formulations were evaluated for morphology, mechanical strength, dissolution time, encapsulation efficiency, antigen release, and immunogenicity in BALB/c mice. The optimized formulation (F4; PVA 15%, PVP K30 10%, HA 1%) showed needle heights of 544.9 ± 15.1 µm, mechanical strength of 0.52 ± 0.04 N/needle, complete dissolution within 15 minutes, and encapsulation efficiency of 94.8 ± 1.8%. Immunogenicity testing demonstrated IgG titers comparable to subcutaneous injection controls. These findings indicate that natural polymer-based DMNs are a promising needle-free and patient-friendly vaccine delivery platform.
Development of Rapid Dispersible Tablet Preparations Using Synthetic and Natural Superdisintegrant Disintegrants: Comparative Performance Analysis putri tri hartini; pertiwi awilda; Ratna mildawati; Khazanah Nurain Nurdin; Dara Sukma Ratmelya
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 1 (2026): May, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i1.525

Abstract

Rapid dispersible tablets (RDTs) are patient-friendly oral dosage forms designed to disintegrate rapidly in the oral cavity or in the presence of a small amount of water, thereby improving patient compliance, particularly among pediatric, geriatric, and dysphagic populations. The performance of RDTs is highly dependent on the type and concentration of superdisintegrants used, as these excipients play a critical role in governing tablet disintegration behavior, wetting characteristics, mechanical strength, and drug release kinetics. Synthetic superdisintegrants such as croscarmellose sodium (CCS) and crospovidone (CPVP) are widely utilized due to their high swelling capacity and capillary action, whereas natural superdisintegrants like Plantago ovata husk (ispaghula husk) have gained increasing interest as eco-friendly and biocompatible alternatives. However, comparative information regarding the efficiency of synthetic and natural superdisintegrants in high-dose drug formulations remains limited. In this study, metformin hydrochloride (500 mg), a high-dose and highly water-soluble antidiabetic drug, was formulated into RDTs using different superdisintegrants via direct compression. The results demonstrated that the optimized formulation containing crospovidone exhibited the fastest disintegration time of 29.1 seconds, along with rapid tablet breakup and efficient drug release, compared to formulations containing croscarmellose sodium and Plantago ovata husk.
Co-Authors Emma Jayanti Besan Khazanah Nurain Nurdin Muhammad Nurul Fadel Nur Masyithah Zamruddin pertiwi awilda putri tri hartini Ratna Mildawati Yuneka Saristiana