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All Journal Fundamental and Applied Research in Medicine and Allied Sciences Indonesia
putri tri hartini
Universitas Muhammadiyah Riau, Indonesia

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Development of Rapid Dispersible Tablet Preparations Using Synthetic and Natural Superdisintegrant Disintegrants: Comparative Performance Analysis putri tri hartini; pertiwi awilda; Ratna mildawati; Khazanah Nurain Nurdin; Dara Sukma Ratmelya
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 1 (2026): May, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i1.525

Abstract

Rapid dispersible tablets (RDTs) are patient-friendly oral dosage forms designed to disintegrate rapidly in the oral cavity or in the presence of a small amount of water, thereby improving patient compliance, particularly among pediatric, geriatric, and dysphagic populations. The performance of RDTs is highly dependent on the type and concentration of superdisintegrants used, as these excipients play a critical role in governing tablet disintegration behavior, wetting characteristics, mechanical strength, and drug release kinetics. Synthetic superdisintegrants such as croscarmellose sodium (CCS) and crospovidone (CPVP) are widely utilized due to their high swelling capacity and capillary action, whereas natural superdisintegrants like Plantago ovata husk (ispaghula husk) have gained increasing interest as eco-friendly and biocompatible alternatives. However, comparative information regarding the efficiency of synthetic and natural superdisintegrants in high-dose drug formulations remains limited. In this study, metformin hydrochloride (500 mg), a high-dose and highly water-soluble antidiabetic drug, was formulated into RDTs using different superdisintegrants via direct compression. The results demonstrated that the optimized formulation containing crospovidone exhibited the fastest disintegration time of 29.1 seconds, along with rapid tablet breakup and efficient drug release, compared to formulations containing croscarmellose sodium and Plantago ovata husk.
Formulation and Characterization of PEGylated Liposomes as a Targeted Delivery System for the Chemotherapy Drug Doxorubicin putri tri hartini; Arbayah; Ziza Putri Aisyia Fauzi; Fendy Prasetyawa; Revan Busriano Putra
Fundamental and Applied Research in Medicine and Allied Sciences Indonesia Vol. 2 No. 1 (2026): May, 2026
Publisher : CV. Get Press Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69855/farmasi.v2i1.526

Abstract

Doxorubicin (DOX) is an effective anticancer agent, but its clinical use is limited by severe systemic toxicity. This study developed and optimized PEGylated liposomes containing DOX to improve therapeutic efficacy and safety. Liposomes were prepared using thin-film hydration and active loading via an ammonium sulfate gradient, and optimized using a Box-Behnken Design. The optimized formulation showed a particle size of ~112 nm, high encapsulation efficiency (94.7%), good stability, and pH-responsive drug release, with greater release under acidic conditions. In vitro studies demonstrated enhanced cytotoxicity against MCF-7 and MDA-MB-231 breast cancer cells compared to free DOX. The formulation also remained stable for 6 months under ICH conditions. Overall, DOX-loaded PEGylated liposomes exhibited favorable physicochemical characteristics, improved anticancer activity, and strong potential as a targeted nanocarrier for breast cancer therapy.
Co-Authors Arbayah Dara Sukma Ratmelya Fendy Prasetyawa Khazanah Nurain Nurdin pertiwi awilda Ratna Mildawati Revan Busriano Putra Ziza Putri Aisyia Fauzi