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All Journal Jurnal Biologi Tropis Window of Health : Jurnal Kesehatan Jurnal Pengabdian Magister Pendidikan IPA Jurnal Dunia Farmasi Indonesian Journal of Pharmaceutical and Clinical Research Journal of Pharmaceutical and Health Research International Journal Of Science, Technology & Management (IJSTM) FORTE JOURNAL Sciences of Pharmacy Jurnal Bakti Nusantara Jurnal Sains dan Kesehatan
Ziza Putri Aisyia Fauzi
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Toxic Effect Of The Compound {1,3 Bis (P-Hydroxyphenyl) Urea} On Triiodothyronine (T3) Hormone Levels In Pregnant White Rats (Rattus Norvegicus L.) Ziza Putri Aisyia Fauzi; Urip Harahap; Yuandani Yuandani; Syukur Berkat Waruwu; Hari Purnomo; Denny Satria
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.719

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs for pregnant women to treat fever, pain and inflammation. Specific NSAIDs can displace thyroid hormone from its protein binding sites, causing thyroid hormone measurement problems. {1,3 bis (p-Hydroxyphenyl)urea} is a modified p-aminophenol compound with potent analgesic and anti-inflammatory activity and less toxicity. This study is a follow-up to previous research to observe the toxic effect on triiodothyronine hormone levels after administration of {1,3 bis(p-Hydroxyphenyl)urea} compound in pregnant white rats. The toxic effect test was carried out by giving the test preparation to pregnant rats, which had been divided into five groups, namely the normal control group (CMC-Na 0.5%), the positive control (Gabapentin 50 mg/kg BW), Compound {1.3 bis (p- Hydroxyphenyl)urea} at a dose of 50 mg/kg BW, 500 mg/kg BW and 1000 mg/kg BW. Mice were given the test preparation every day from the 6th to the 15th day of pregnancy. Blood was taken on the 16th day, and T3 hormone levels were measured using the ELISA method. The results showed that the T3 hormone levels in the {1,3 bis(p-Hydroxyphenyl)urea group had no significant difference from the normal control group, so it was concluded that {1,3 bis(p-Hydroxyphenyl)urea) did not have a significant effect on the hormone T3.
Analisis Tingkat Kepuasan Pasien terhadap Kualitas Pelayanan Resep di Instalasi Farmasi Rumah Sakit Tentara Binjai Ginting, Ovalina Sylvia Br.; Lestari, Amanda Putri; Rambe, Robiatun; Rani, Zulmai; Fauzi, Ziza Putri Aisyia; Dalimunthe, Gabena Indrayani; Harahap, Aswan Pangondian; Chandra, Putra
Jurnal Dunia Farmasi Vol 8, No 3 (2024): Edisi Agustus
Publisher : LPPM Institut Kesehatan Helvetia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33085/jdf.v8i3.6152

Abstract

Pendahuluan: Pelayanan kefarmasian rumah sakit merupakan bagian yang tidak terpisahkan dari sistem pelayanan kesehatan yang ada dirumah sakit yang berorientasi kepada pelayanan pasien, penyediaan obat, maupun pelayanan farmasi klinik. Tujuan: Tujuan penelitian ini adalah untuk mengetahui tingkat kepuasan pasien terhadap pelayanan kefarmasian di Rumah Sakit Tentara Binjai. Metode: Penelitian ini menggunakan metode survei deskriptif melalui penyebaran kuesioner. Populasi pada penelitian ini adalah seluruh pasien rawat jalan BPJS yang berobat di Rumah Sakit Tentara Binjai. Teknik pengambilan sampel pada penelitian ini adalah Random Sampling. Besar sampel dalam penelitian ini sebanyak 100 orang. Hasil: Hasil penelitian ini menunjukkan bahwa kategori tingkat kepuasan terbesar yaitu pada dimensi ketanggapan dan jaminan memiliki skor yang sama yaitu sebanyak 83,60% dengan kategori  puas, dimensi empati 83,52%dengan kategori puas, dimensi kehandalan 80,68% dengan kategori puas, dan  dimensi bukti fisik 76,60%dengan kategori puas. Kesimpulan: Kesimpulan dari penelitian ini yang berdasarkan 5 dimensi kualitas pelayanan adalah puas dengan persentase sebanyak 81,60% dengan kategori puas.
Potensi Buah Rimbang (Solanum torvum Sw.) sebagai Analgetik dengan Metode Induksi Asam Asetat dan plantar test Utami, Dinda Sari; Nasution, Melvi Ariati; Fauzi, Ziza Putri Aisyia; Sari, Syilvi Rinda; Hartini, Putri Tri; Rawitri, Kiki
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5057

Abstract

Abstract is Solanum torvum is a traditional medicine plant ingredient for treating stomach disease, relieving pain (analgesic), initiating blood circulation, removing cough (anti-tussing) and anti-inflammatory. At this examination, a phytochemical screening of powder and fruit extracts has been carried out. Simplicity characteristic tests and analgesic effect tests with acetate acid induction method and plantar tests with suspensions of ethanol extract are given in doses of 500, 1000 and 2000 mg/kgBB, metampiron suspense 2% positive ontrol, CMC suspense 0.5% as negative control as well as gland data are analyzed with ANOVA method. Results of screening of phytomia powder and ethanole extract contains secondary metabolite compounds of the classes of alkaloids, tannins, saponins, flavonoids, steoids and glycosides. Characteristic results of simplisia powder are 8% water content, 5.3% total ash content, 29.6% water-soluble sulphur content, 18.9% ethanol-solubility, 0.48% acid-insoluble ash content. Ethanol extract with 2000 mg/kgBB acetate acid induction method has the highest analgesic strength and effectiveness percentage of 55.9% and 86.04% for plantar test methods with hight analgetic values with 29,3±1,7 second.
Uji Sitotoksisitas Ekstrak Etanol Daun Bayam Duri (Amaranthus spinosus L.) dengan Metode Brine Shrimp Lethality Test (BSLT) Fauzi, Ziza Putri Aisyia; Ridwanto, Ridwanto; Rani, Zulmai; Arifin, Khairil Fikri
Journal of Pharmaceutical and Health Research Vol 5 No 2 (2024): June 2024
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v5i2.5398

Abstract

Free radicals can cause chronic disease, it takes years for the disease to become real or accumulative. One possibility that can occur as a result of the work of free radicals such as cancer. Cancer is one of the non-communicable diseases that is a public health problem, both in the world and in Indonesia. One of the plants that has the potential as an anticancer is Amaranthus spinosus L. The results showed that thorn spinach leaves contain strong antioxidants. This study aims to determine the class of secondary metabolites contained in the ethanolic extract of thorn spinach leaves and the cytotoxicity of the ethanolic extract of A.spinosus by looking at the LC50 value which was tested using the Brine Shrimp Lethality Test (BSLT) method. This research includes phytochemical screening of A.spinosus extract and Brine Shrimp Lethality Test (BSLT) method by looking at the number of larvae mortality of Artemia salina leach (LC50). The results of the phytochemical screening test showed that A.spinosus were positive for flavonoids, alkaloids, saponins, tannins, steroids and glycosides. The results of the cytotoxicity test using probit analysis showed an LC50 value of 269.15 g/mL, so it can be concluded that the ethanolic extract of A.spinosus is toxic and has potential as an anticancer.
Edukasi Penggunaan Antibiotik yang Benar dalam Mencegah Resistensi Antibiotik Rinda Sari, Sylvi; Yunus, Muhammad; Fauzi, Ziza Putri Aisyia; Rani, Zulmai; Nasution, Muhammad Amin; Pertiwi, Nia Novranda; Syahputri, Hindri
Jurnal Bakti Nusantara Vol. 2 No. 1 (2024): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jbn.v2i1.55

Abstract

Penggunaan antibiotik yang tidak benar memunculkan problematika kesehatan dalam masyarakat.  Alih-alih menjadi obat dalam mengatasi infeksi oleh bakteri, penggunaan antibiotik yang salah dapat menyebabkan resistensi dimana antibiotik tidak dapat membunuh bakteri di dalam tubuh dan akan kebal terhadap infeksi bakteri yang sama. Pengabdian kepada masyarakat ini bertujuan memberikan edukasi penggunaan antibiotik yang benar kepada masyarakat sekitar Apotek Farmasi Universitas Muslim Nusantara Al Washliyah Medan, untuk menghindari resistensi antibiotik. Kegiatan edukasi dilakukan dengan metode ceramah, diskusi dan tanya jawab. Penilaian terhadap keberhasilan kegiatan dilakukan dengan menggunakan kuesioner. Hasil kuisioner menunjukkan ketertarikan peserta akan kegiatan sebesar 95,25%, memahami informasi obat sebesar 87,52%, dan pengetahuan peserta terhadap penggunaan antibiotik yang benar sebesar 90,74%. Edukasi ini terbukti dapat meningkatkan pemahaman masyarakat mitra tentang penggunaan antibiotik yang benar dalam mencegah resistensi antibiotik.
PROFIL PENGGUNAAN OBAT TUBERCULOSIS MULTI DRUG RESISTANT (MDR) DI RSUD DR. MOEWARDI SURAKARTA, JAWA TENGAH Aulia Fitri; Zulmai Rani; Robiatun Rambe; Ziza Putri Aisyia Fauzi
FORTE JOURNAL Vol 4 No 1 (2024): Edisi Januari 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v4i1.777

Abstract

Tuberkulosis Multi Drug Resistant (TB MDR) adalah TB yang disebabkan oleh resistensi kuman tuberkulosis terhadap dua jenis obat anti tuberkulosis (OAT) lini pertama, isoniazid dan rifampisin, baik bersamaan dengan atau tanpa OAT tambahan. Secara global insiden kasus TB MDR pada tahun 2016 berkisar 153.000 pasien dan diantaranya ada 130.000 pasien baru yang memulai pengobatan TB MDR di tahun tersebut, sedangkan keberhasilan terapi TB MDR terhadap pasien yang memulai pengobatan sejak 2014 sebanyak 54%. Total kasus TB MDR pada tahun tersebut juga diketahui pasien meninggal sebanyak 16% dan 8% lainnya gagal dalam pengobatan. Riset ini menggunakan metode deskriptif non-eksperimenal dengan desain penelitian potong lintang yang dilakukan setiap bulan. Data dikumpulkan di Poliklinik TB MDR RSUD dr. Moewardi dari Mei hingga Agustus 2019 melalui penelusuran rekam medis pasien. Hasil penelitian menunjukkan bahwa jenis kelamin laki-laki, sebanyak 67 orang (57,26 persen), orang di bawah 60 tahun, sebanyak 103 orang (88,03 persen), dan orang dengan berat badan tertinggi 33 hingga 50 kg, sebanyak 61 orang (52,10 persen). Jenis obat yang paling banyak dikonsumsi yaitu <10 adalah 63 orang (53,80%), tanpa komorbiditas sebanyak 76 orang (64,96%), riwayat tuberculosis yang kambuh sebanyak 39 orang (33,33%), riwayat sosial yang merokok sebanyak 32 orang (27,35%). Hasil penelitian menunjukkan bahwa yang paling umum adalah pria dan orang di bawah 60 tahun. Pola peresepan obat TB MDR berdasarkan jenis obat yang paling umum digunakan adalah kurang dari 10.
Optimization of HPMC Aand Carbopol 940 Bases in the Formulation of Red Beet (Beta vulgaris L.) Gel Preparations as Hair Dye Hartini, Putri Tri; Fauzi, Ziza Putri Aisyia; Utami, Dinda Sari; Karo-Karo, Sry Ulina; Puteri, Cut Intan Annisa
Journal of Pharmaceutical and Health Research Vol 6 No 1 (2025): February 2025
Publisher : Forum Kerjasama Pendidikan Tinggi (FKPT)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47065/jharma.v6i1.6661

Abstract

Red beet (Beta vulgaris L.) is grass-shaped plant with short stems. Betacyianine is a red or purplish red pigment, while the betaxantin pigment has yellow colour and when diluted in water will form a red solution. This study aims to formulate hair dye gel with red beet juiceas colorant, evaluate the coloring capacity of the gel, and evaluate the stability of the formulation. 114.43 grams red beet juice was obtained using juicer, with yield percentage 55.76%. Phytochemical screening indicated alkaloid, tannin, flavonoid and saponin content. Hair dye gel is formulated in three different concentrations, F1 (10%), F2 (20%), F3 (30%) using combination of Carbopol 940 (0.5%) and HPMC (1%) as gel base. Hair dye gel obtained has beet distinctive smell. Evaluation results for the three-formulation showed that the color changed in all formulas. Color changing is influenced by pH degree of the formulation and temperature. The original color of the preparation only stable for 5 days, then the color changed due to oxidation at room temperature. Stability evaluation was conducted using Cycling Test method for 6 cycles in 12 days. All formula showed discoloration after 6 cycles from purple to brownish and they also showed viscosity change, F1 13673,34 cPs; F2 11826,67 cPs; dan F3 10673,34 cPs.
Uji Antibakteri Ekstrak Etanol Daun Mangga Golek (Mangifera indica L.) terhadap Bakteri Staphylococcus aureus: Antibacterial Test of Ethanol Extract of Golek Mango Leaves (Mangifera indica L.) Against Staphylococcus aureus Bacteria Yuniarti, Rafita; Rukmana, Siti; Nasution, Haris Munandar; Rani, Zulmai; Fauzi, Ziza Aisyia Putri
Jurnal Sains dan Kesehatan Vol. 7 No. 2 (2025): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v7i2.2427

Abstract

Mango golek is among the numerous beneficial plants in the Mangifera genus. Mango leaves have antibacterial, antifungal, antiviral, and antiparasitic properties. The purpose of this research was to determine how effective an ethanol extract of mango golek leaves was against Staphylococcus aureus bacteria and what kind of secondary metabolites were present in the extract. This study employed laboratory experimental methods such as the maceration method with 70% ethanol solvent, phytochemical screening test, and Mango golek leaf extract (Mangifera indica L.) Staphylococcus aureus antimicrobial activity test at various concentrations of 100 mg/day. mL, 70, 50, 30, and 10 mg/mL using the agar diffusion method. Mango golek leaves ethanol extract included alkaloids, flavonoids, saponins, tannins, and steroids/triterpenoids, according to the screening results. values of 100 mg/mL and 70 mg/mL were considered high, while values of 50 and 30 mg/mL were considered moderate. Keywords:          cMangifera indica L., Staphylococcus aureus   Abstrak Salah satu tanaman dari genus Mangifera adalah mangga golek yang memiliki banyak manfaat. Salah satu keuntungan adalah sifat antiparasit, antijamur, antivirus, dan antibakterinya. Tujuan penelitian ini adalah untuk mengetahui seberapa efektif ekstrak daun mangga golek terhadap Bakteri Staphylococcus aureus dan mengidentifikasi metabolit sekundernya. Dalam penelitian ini, menggunakan metode eksperimental yang meliputi uji fitokimia, pembuatan pelarut etanol 70% dari ekstrak daun mangga golek (Mangifera indica L.), dan uji antibakteri Staphylococcus aureus dengan konsentrasi 100, 70, 50, 30, dan 10 mg/mL menggunakan metode difusi agar. Hasil skrining, ekstrak etanol daun mangga golek mengandung alkaloid, flavonoid, saponin, tanin, dan steroid/triterpenoid. Uji antibakteri, ekstrak daun mangga golek memiliki sifat antimikroba Staphylococcus aureus dengan kategori kuat 100 dan 70 mg/mL dan kategori sedang 50 dan 30 mg/mL. Kata Kunci:         Antibakteri, Mangifera indica L, Staphylococcus aureus
Edukasi Kesehatan dan Obat Hipertensi pada Lansia Utami, Dinda Sari; Fauzi, Ziza Putri Aisyia; Rani, Zulmai
Jurnal Bakti Nusantara Vol. 1 No. 2 (2023): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jbn.v1i2.37

Abstract

Hipertensi adalah penyakit yang umum terjadi, terutama pada kalangan lanjut usia atau lansia. Hipertensi yang terdapat pada lansia sebagian besar adalah tekanan darah sistolik terisolasi (HST). International Society of Hypertension (ISH) tahun 2020 menyebutkan bahwa, peningkatan tekanan darah penyebab utama kematian secara global, menyebabkan 10.4 juta kematian per tahun. Angka global diperkirakan sebanyak 1.39 miliar orang mengidap hipertensi pada tahun 2010. Sasaran langsung kegiatan adalah pra lanjut usia (45-59 tahun), lanjut usia (60-69 tahun), dan lanjut usia risiko tinggi (lanjut usia >70 tahun atau usia >= 60 tahun dengan masalah kesehatan). Tujuan dari pengabdian kepada masyarakat ini adalah agar para lansia lebih memahami tentang hipertensi. Metode dalam pengabdian masyarakat ini adalah edukasi berbentuk sosialisasi mengenai hipertensi dan praktik pemeriksaan tekanan darah langsung kepada mitra. Hasil dalam kegiatan pengabdian masyarakat berupa meningkatnya pengetahuan lansia mengenai hipertensi.
Utilization Of Corn Starch Amylopectin (Zea mays L.) For Coating Acetylsalicylic Acid Tablets Dalimunthe, Gabena Indrayani; Rani, Zulmai; Fauzi, Ziza Aisyia Putri; Samran, Samran; Nindya Indah Damayanti; Siti Anisa
Window of Health : Jurnal Kesehatan Vol 8 No 2 (April 2025)
Publisher : Fakultas Kesehatan Masyarakat Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/woh.v8i2.1380

Abstract

Aspirin or acetylsalicylic acid is a class of NSAIDs stable in dry air, in humid air aspirin will over time hydrolyze or decompose into salicylic acid and acetic acid, with the decomposition of aspirin levels that contained in the preparation will experience degradation. Acetylsalicylic acid needs to be made in the form of thin-coated or film-coated tablets. In this research, the method used was tablet coating, followed by evaluation tests of core tablets and coated tablets. The results of this study indicate that amiloCorn starch pectin can be used as a thin layer and enteric coating. The coated tablet formulation from corn starch amylopectin has evaluation test results, namely the formula 1 tablet hardness test is 4.28 kg, formula 2 is 4.94 kg, formula 3 is 4.63 kg, size uniformity test is the diameter and thickness of formula 1 is 10.93 and 3.67 mm, formula 2 is 11.33 and 3.98 mm, formula 3 was 10.95 and 3.70 mm, average weight uniformity test for formula 1 was 389.5 mg, formula 2 was 399.5 mg, formula 3 was 393 mg, disintegration time test for formula 1 in stomach medium was 13, 31 minutes, formula 2 in the stomach medium 20.25 minutes, formula 3 in the intestinal medium 2.44 minutes, dissolution test for formula 1 in 120 minutes the solubility of the active substance reached 84%, formula 2 was 82%, formula 3 was 3% and intestinal dimedium within 210 minutes. The best formula, namely formula 3, meets the requirements for coated film.
Co-Authors Ahmad Rasyid Ridho Anita Naibaho, Tri Aprilia, Hijjatun Arifin, Khairil Fikri Aska, Nawalul Aulia Fitri Candrika, Candrika Chandra, Putra Denny Satria Dewi, Sri Harti Dinda Sari Utami Gabena Indrayani Dalimunthe Ginting, Ovalina Sylvia Br Ginting, Ovalina Sylvia Br. Hari Purnomo Haris Munandar Nasution Hartini, Putri Tri Hindri Syahputri Karo-Karo, Sry Ulina Lestari, Amanda Putri Lubis, Minda Sari Lubis, Syahnan Aly Muhammad Amin Nasution Muhammad Andry Muhammad Yunus Nabila Nasri Nasri, Nasri Nasution, Melvi Ariati Nia Novranda Pertiwi Nindya Indah Damayanti Ningtias, Anggitha Puteri, Cut Intan Annisa Putri, Cut Intan Annisa Rafita Yuniarti Rambe, Robiatun Rawitri, Kiki Ridho, Ahmad Rasyid Ridwanto Ridwanto Rinanda Silitonga, Desni Rinda Sari, Sylvi Robiatun Rambe Rukmana, Siti Samran, Samran Sari, Syilvi Rinda Simahate, Sadjnah Siti Anisa Sry Ulina Karo-karo Syukur Berkat Waruwu Urip Harahap Vera Estefania Kaban Yuandani Yuniarti, Rafita Zulmai Rani