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All Journal JOPS (Journal Of Pharmacy and Science)
Yoan Dasawanti
Sekolah Tinggi Ilmu Kesehatan Sehat Medan
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Penentuan Nilai Konsentrasi Hambat Minimum (KHM) dan Konsentrasi Bunuh Minimum Minyak Daun Cengkeh (Syzygium Aromaticum) terhadap Propionibacterium acnes: Determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of Clove Leaf Oil (Syzygium Aromaticum) against Propionibacterium acnes Yoan Dasawanti; Candrika Candrika
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.6001

Abstract

Infectious diseases are conditions caused by the entry of microorganisms into the body, leading to illness. One of the causes of infection is the bacterium Propionibacterium acnes. Continuous use of antibiotics can lead to resistance, thus alternative treatments such as the use of natural substances are needed. One of these alternatives is clove leaf. Clove leaves contain essential oil ranging from 1-4%, with eugenol as the main component. Eugenol has pharmacological activity as both an antimicrobial and anti-inflammatory agent. This study aims to determine the antibacterial activity of clove leaf oil against Propionibacterium acnes, specifically in determining the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). Clove leaf oil was obtained through water distillation with a yield of 2.88%. The MIC test was performed using the agar diffusion method, while the MBC test was conducted using the streaking method. The results showed that clove leaf oil exhibits antibacterial activity that increases with increasing concentration. The MIC was obtained at a concentration of 5 mg/mL with a zone of inhibition diameter of 8.13 mm, while the MBC was at a concentration of 20 mg/mL. This antibacterial activity is attributed to the eugenol content in clove leaf oil, which can damage bacterial cell membranes and increase intracellular protein leakage. These findings indicate that clove leaf oil has potential as an effective natural antibacterial agent against Propionibacterium acnes and could serve as an alternative herbal treatment. Keywords: Clove leaf oil , KHM, KBM, Propionibacterium acnes
Formulasi Body Butter Ekstrak Etanol Daun Kelor (Moringa Oliefera L.) Dan Uji Efektivitas Sebagai Pelembab Kulit Yoan Dasawanti; Ade Rosa Arianti Nasution; Irsa Amalia Tuz Zahara
JURNAL FARMASI DAN MAKANAN Vol 9 No 1 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i1.7304

Abstract

Background: Moringa leaves contain secondary metabolites with antioxidant activity that play a role in maintaining skin moisture. Body butter is a cosmetic preparation that is more effective in retaining skin moisture compared to other topical formulations. Objective: To determine the effectiveness of body butter containing Moringa oleifera L. leaf extract in improving skin moisture. Methods: This study was an experimental research. Moringa leaf extraction was carried out using the maceration method. The extract was formulated into body butter at concentrations of 5% (FI), 7% (FII), and 9% (FIII), while the base formulation without extract (F0) served as a negative control. The prepared formulations were evaluated for physical properties, including organoleptic characteristics, homogeneity, pH, viscosity, formulation stability, and skin irritation. The moisturizing effectiveness was measured using a skin analyzer. Results: The results showed that all body butter formulations containing moringa leaf extract were physically stable and did not cause skin irritation. The moisturizing test demonstrated a significant increase in skin moisture at all extract concentrations. The 9% extract formulation (FIII) showed the highest increase in skin moisture, from 18.33% to 57.33% after four weeks, approaching the effectiveness of the positive control (59%). These findings indicate that the moisturizing effectiveness increased with higher extract concentrations. Conclusion: Ethanolic extract of Moringa oleifera L. leaves can be formulated into a stable body butter preparation and is effective as a skin moisturizer. Keywords: Moringa oleifera leaves, body butter, moisturizer, skin analyzer
Potensi Ekstrak Etanol Daun Sukun (Artocarpus altilis) sebagai Antidiabetes pada Tikus Putih Jantan Galur Wistar yang Diinduksi Aloksan Yoan Dasawanti; Farah Dhiba; Mawandha Sari Harahap; Ade Rosa Arianti Nasution; Nova Susilawati
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.8102

Abstract

Latar Belakang: Diabetes melitus adalah gangguan metabolisme yang ditandai dengan peningkatan kadar glukosa darah akibat gangguan sekresi insulin atau kerja insulin. Daun sukun ( Artocarpus altilis ) mengandung metabolit sekunder dengan potensi sifat antidiabetes. Tujuan: Penelitian ini bertujuan untuk mengevaluasi aktivitas antidiabetik ekstrak etanol daun sukun dalam menurunkan kadar glukosa darah pada tikus Wistar jantan yang diinduksi aloksan. Metode: Studi eksperimental dilakukan menggunakan 30 tikus Wistar jantan yang dibagi menjadi enam kelompok. Kelompok normal tidak diinduksi dengan aloksan, sedangkan kelompok lain diinduksi dengan aloksan. Ekstrak etanol daun sukun diberikan pada dosis 150, 300, dan 600 mg/kgBW. Kadar glukosa darah diukur pada hari ke-0, 5, 10, dan 15. Data dianalisis menggunakan ANOVA Satu Arah diikuti dengan uji Post Hoc Tukey HSD. Hasil: Pada hari ke-15, kadar glukosa darah rata-rata pada kelompok yang diberi ekstrak dengan dosis 150, 300, dan 600 mg/kgBW masing-masing adalah 251,0 ± 30,1 mg/dL, 251,6 ± 35,6 mg/dL, dan 192,4 ± 31,0 mg/dL. Dosis 600 mg/kgBW menunjukkan penurunan kadar glukosa darah terbesar dan menunjukkan kemanjuran yang mendekati glimepiride (174,4 ± 27,6 mg/dL). Kesimpulan: Ekstrak etanol daun sukun ( Artocarpus altilis ) menunjukkan aktivitas antidiabetes pada tikus yang diinduksi aloksan, dengan dosis 600 mg/kgBW menunjukkan efektivitas tertinggi. Kata kunci: Artocarpus altilis; aloksan; aktivitas antidiabetes; kadar glukosa darah.
Co-Authors Ade Rosa Arianti Nasution Ade Rosa Arianti Nasution Candrika, Candrika Farah Dhiba Irsa Amalia Tuz Zahara Mawandha Sari Harahap Nova Susilawati