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All Journal JOPS (Journal Of Pharmacy and Science)
Kiki Rawitri
Program Studi Pendidikan Profesi Apoteker, Fakultas Farmasi, Universitas Muslim Nusantara Al Washliyah, Medan
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Potential Antibiotic-Drug Interactions in Hospitalized Patients : A Retrospective Cross Sectional Study Syilvi Rinda Sari; Kiki Rawitri; Hindri Syahputri; Muhammad Amin Nasution; Nia Novranda Pertiwi
JURNAL FARMASI DAN MAKANAN Vol 8 No 2 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v8i2.6018

Abstract

 Infectious diseases are frequently seen in hospitalized patients, and antibiotics are among the most commonly prescribed drugs. Patients in the hospital frequently experience drug interactions because their severe conditions frequently necessitate the simultaneous administration of many medications. This study aims to determine the frequency of potential drug interactions between antibiotics and other drugs in hospitalized patients at Dr. Pirngadi Hospital, Medan, Indonesia. This study uses an observational method with a retrospective cross-sectional study design on 300 patients who met the inclusion criteria in January-December 2023. Potential antibiotic drug interactions seen from the Medscape application. The results showed that only 20.33% of the total sample experienced potential interactions between antibiotics and other drugs in patients at Dr. Pirngadi Hospital in the period January-December 2023, namely only 61 patients from a total sample of 300 patients with 84 cases of potential interactions between antibiotics and other drugs. The potential drug interactions that occur are pharmaceutically as much as 5.26%, pharmacokinetically as much as 10.53%, and the majority, pharmacodynamically, as much as 84.21%.
Co-Authors Hindri Syahputri Muhammad Amin Nasution Nia Novranda Pertiwi Sari, Syilvi Rinda