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All Journal JOPS (Journal Of Pharmacy and Science)
Minda Sari Lubis
Fakultas Farmasi, Institut Universitas Muslim Nusantara Al Washliyah Medan
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Formulasi dan Aktivitas Antibakteri Patch Anti Jerawat Ekstrak Kulit Nanas (Ananas Comosus (L.) Merr.) terhadap Propionibacterium acnes dan Staphylococcus epidermidis: Formulasi dan Aktivitas Antibakteri Patch Anti Jerawat Ekstrak Kulit Nanas (Ananas Comosus (L.) Merr.) terhadap Propionibacterium acnes dan Staphylococcus epidermidis fatimah; Gabena Indrayani Dalimunte; Minda Sari Lubis; Zulmai Rani
JURNAL FARMASI DAN MAKANAN Vol 9 No 1 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i1.7391

Abstract

Acne is a common skin issue among teenagers, primarily caused by bacterial infections from Propionibacterium acnes and Staphylococcus epidermidis. Pineapple peel has been found to contain antibacterial properties that can help treat acne. This study aims to evaluate the antibacterial effectiveness of an anti-acne patch made from pineapple peel extract (Ananas comosus (L.) Merr.) against these two bacteria. The pineapple peel extract was obtained through a reflux extraction method, followed by phytochemical screening, which identified the presence of flavonoids, saponins, tannins, and triterpenoids. The extract was then formulated into patches with concentrations of 5%, 10%, and 15% and tested for antibacterial activity. Physical evaluations showed that the patches had an appropriate pH (4.5-5.5), uniform weight (CV < 5%), acceptable thickness (0.1-0.3 mm), moisture content below 10%, and did not cause irritation in volunteers. Antibacterial testing using the agar diffusion method showed the highest inhibition zones for P. acnes at 21.1 mm and S. epidermidis at 18.2 mm at a 15% concentration. Meanwhile, the well-diffusion method showed inhibition zones ranging from 12 to 21.8 mm for P. acnes and 12.7 to 24.7 mm for S. epidermidis across various concentrations. These results suggest that pineapple peel extract and its patch formulation have strong antibacterial activity, indicating potential as an acne treatment. Keywords: anti-acne patch, pineapple peel extract, Propionibacterium acnes, Staphylococcus epidermidis, antibacterial activity.
Formulasi Tablet ODT Natrium Diklofenak Menggunakan Kombinasi Disintegran Pati Kacang Hijau dan Pati Kentang : ODT FORMULATION OF DICLOFENAC SODIUM COMBINED WITH MUNG BEAN STARCH (Vigna radiata (L.) R.Wilczek) AND POTATO STARCH (Solanum tuberosum L.) AS A DISINTEGRANT rizka; Gabena Indrayani Dalimunthe; Minda Sari Lubis; Rafita Yuniarti
JURNAL FARMASI DAN MAKANAN Vol 9 No 1 (2025): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i1.7392

Abstract

Green beans and potatoes are plants that have very high starch purity which can be used as excipients, especially disintegrants in tablet formulations. Diclofenac sodium is one of the most frequently prescribed anti-inflammatories and is consumed by many elderly patients. Meanwhile, elderly patients often have difficulty swallowing conventional tablets. Orally disintegrating tablet (ODT) is a solid dosage form that quickly disintegrates when placed on the tongue and is expected to be a solution for patients who have difficulty swallowing conventional tablets. This research aims to formulate Orally disintegrating Diclofenac Natrium tablets with a combination of disintegrating ingredients, namely potato starch and green bean starch and to obtain the disintegrating ingredient composition in the optimum formula. Orally disintegrating tablets are made using the direct compression method with a tablet weight of 200 mg. Tablet preformulation tests were carried out including flow time tests, angle of repose tests, bulk density tests and compressibility index tests. And the tablet physical quality evaluation tests include weight uniformity test, hardness test, firmness test, disintegration time test, wetting time test, and disintegration time test in the mouth. The research results showed that the preparation of Orally disintegrating Diclofenac Natrium tablets met the requirements for good physical properties. The fastest tablet disintegration time test was produced by formula 6 and the longest disintegration time test was produced by formula 1. Mung bean starch and potato starch can be used as disintegrants in the formulation of Orally disintegrating Diclofenac Sodium tablets. Keywords : Orally Disintegrating Tablets, Diclofenac Sodium, Green beans, ..Potatoes, Disintegrant
Co-Authors fatimah Gabena Indrayani Dalimunte Gabena Indrayani Dalimunthe Rafita Yuniarti rizka Zulmai Rani