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All Journal JOPS (Journal Of Pharmacy and Science) Jurnal Buana Farma
Roy Indrianto Bangar
Department of Clinical Pharmacy, Faculty of Health Sciences, Universitas Prima Indonesia, Medan, 20118, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Antibacterial Activity of Graded Extract of Sikkam Stem Bark (Bischofia javanica Blume) Against Staphylococcus aureus Shintjia Dewi Agustan; Vera Estefania Kaban; Astriani Natalia Br Ginting; Roy Indrianto Bangar
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7819

Abstract

Antibiotic resistance in represents a serious global health challenge, driving the search for alternative antibacterial agents from natural sources. The stem bark of the sikkam tree (Bischofia javanica Blume) has bioactive potential, yet systematic evaluation of its antibacterial activity based on solvent polarity remains limited. This study aimed to investigate the antibacterial potential of graded extracts of Sikkam stem bark against Staphylococcus aureus. Extraction was performed by graded maceration and antibacterial activity was assessed using the disc diffusion method, with amoxicillin and dimethyl sulfoxide serving as positive and negative controls, respectively. Phytochemical screening revealed the presence of phenolics, flavonoids, alkaloids, tannins, saponins, steroids/terpenoids, and quinones. Among the tested extracts, the ethyl acetate extract showed the highest yield (44.65%) and exhibited the strongest antibacterial activity, producing an inhibition zone of 13.75 ± 0.09 mm at concentration 500 mg/mL The ethanol extract also demonstrated strong and consistent inhibition zone of 12.90 ± 0.13 mm, while the n-hexane extract showed the lowest activity, with an inhibition zone of 10.86 ± 0.20 mm. This study indicates that ethyl acetate and ethanol extracts of sikkam stem bark have potential as natural antibacterial agents against Staphylococcus aureus.
FORMULASI SEDIAAN HAND BODY GEL DENGAN SARI BUAH RAMBUTAN (Nephelium lappaceum L.) Nailan Azizah; Nerly Juli Pranita Simanjuntak; Roy Indrianto Bangar
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1673

Abstract

Rambutan fruit (Nephelium lappaceum L.) contains vitamins A, B, and C, which act as antioxidants and are beneficial for skin health. The utilization of rambutan fruit juice in a hand body gel formulation aims to produce a natural moisturizing product that is safe for use. This study was conducted experimentally by formulating rambutan fruit juice into hand body gel at concentrations of 3%, 5%, and 7%, along with a blank formulation. Each formulation was evaluated for its physical properties, including organoleptic characteristics, homogeneity, pH, spreadability, and viscosity. In addition, skin irritation testing and skin moisture testing using a skin analyzer were performed over three weeks of use. The results showed that all formulations had good physical quality, pH values suitable for the skin, and did not cause irritation. Skin moisture testing indicated an increase in skin moisture in all formulations, with the 7% concentration showing the highest improvement. In conclusion, rambutan fruit juice can be formulated into a hand body gel that is safe and effective as a skin moisturizer, with the 7% concentration being the best formulation.
Co-Authors Astriani Natalia Br Ginting Nailan Azizah Nerly Juli Pranita Simanjuntak Shintjia Dewi Agustan Vera Estefania Kaban