Article Per Year (5 Year)
p-Index From 2021 - 2026
0.562
P-Index
This Author published in this journals
All Journal Jurnal Buana Farma Herbal Medicine Journal
Nerly Juli Pranita Simanjuntak
PUI Phyto Degenerative & Lifestyle Medicine, Universitas Prima Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
Aktivitas Antioksidan dan Inhibitor Enzim Tirosinase Ekstrak Daun Jeruk Manis (Citrus sinensis L.) Runitasari Saragih; Edy Fachrial; Nerly Juli Pranita Simanjuntak
Herbal Medicine Journal Vol 9 No 1 (2026): Herbal Medicine Journal
Publisher : Program Studi S1 Farmasi, STIKES Senior, Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58996/hmj.v9i1.211

Abstract

Sweet orange leaves (Citrus sinensis L.) are a potential source of bioactive compounds that can be developed as natural antioxidants and tyrosinase inhibitors for the prevention of premature skin aging and hyperpigmentation. This study aimed to evaluate the phytochemical constituents, antioxidant activity, and tyrosinase inhibitory potential of the ethanol extract of sweet orange leaves. Extraction was carried out using ultrasonic-assisted extraction with 70% ethanol as the solvent. Phytochemical screening revealed the presence of flavonoids, tannins, alkaloids, and steroids, while saponins were not detected. Antioxidant activity was evaluated using the DPPH radical scavenging method at concentrations of 200–500 ppm and showed a concentration-dependent increase in inhibition, with values of 76.46% (200 ppm), 78.61% (300 ppm), 82.32% (400 ppm), and 84.43% (500 ppm), indicating strong antioxidant activity. Tyrosinase inhibition was assessed using L-DOPA as the substrate and demonstrated inhibition percentages of 51.13% and 51.01%, indicating good inhibitory activity. Based on these findings, thethanol extract of sweet orange leaves exhibits promising antioxidant and tyrosinase inhibitory properties and may be further developed for pharmaceutical and cosmetic applications, particularly as natural anti-aging and antihyperpigmentation agents.
EFEKTIVITAS GEL DAUN KIPAHIT (Tithonia diversifolia) TERHADAP PENYEMBUHAN LUKA DIABETES PADA TIKUS Siti Khadijah; Astriani Natalia Br Ginting; Nerly Juli Pranita Simanjuntak
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1614

Abstract

Diabetes mellitus is a chronic disease commonly associated with complications such as diabetic wounds, which are characterized by impaired tissue perfusion, prolonged inflammation, and increased susceptibility to infection, resulting in delayed wound healing. Although various topical therapies have been developed, the use of herbal-based formulations for diabetic wound management remains an area of ongoing research. Leaves of Tithonia diversifolia are known to contain secondary metabolites such as flavonoids, tannins, alkaloids, and saponins, which may support the wound healing process. This study aimed to evaluate the effectiveness of Tithonia diversifolia leaf extract gel on wound healing in streptozotocin (STZ)-induced diabetic rats. This experimental study used 30 male white rats divided into six groups: normal control, negative control (gel base), positive control (octeniline gel), and treatment groups receiving Tithonia diversifolia extract gel at concentrations of 5%, 10%, and 15%. The extract was obtained by maceration using 70% ethanol and formulated into a topical gel. Wound length was observed on days 0, 3, 7, and 14, and the data were analyzed using One-Way ANOVA followed by Tukey HSD test. The results showed that Tithonia diversifolia extract gel significantly affected wound healing from day 3 to day 14 (p < 0.05). The 10% and 15% formulations demonstrated better wound healing than the negative control, while the 15% formulation showed the most optimal result, with a mean wound length of 0.40 mm on day 14. Therefore, Tithonia diversifolia extract gel has potential to be developed as a topical preparation supporting wound healing under diabetic conditions.
FORMULASI SEDIAAN HAND BODY GEL DENGAN SARI BUAH RAMBUTAN (Nephelium lappaceum L.) Nailan Azizah; Nerly Juli Pranita Simanjuntak; Roy Indrianto Bangar
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1673

Abstract

Rambutan fruit (Nephelium lappaceum L.) contains vitamins A, B, and C, which act as antioxidants and are beneficial for skin health. The utilization of rambutan fruit juice in a hand body gel formulation aims to produce a natural moisturizing product that is safe for use. This study was conducted experimentally by formulating rambutan fruit juice into hand body gel at concentrations of 3%, 5%, and 7%, along with a blank formulation. Each formulation was evaluated for its physical properties, including organoleptic characteristics, homogeneity, pH, spreadability, and viscosity. In addition, skin irritation testing and skin moisture testing using a skin analyzer were performed over three weeks of use. The results showed that all formulations had good physical quality, pH values suitable for the skin, and did not cause irritation. Skin moisture testing indicated an increase in skin moisture in all formulations, with the 7% concentration showing the highest improvement. In conclusion, rambutan fruit juice can be formulated into a hand body gel that is safe and effective as a skin moisturizer, with the 7% concentration being the best formulation.
Co-Authors Astriani Natalia Br Ginting Edy Fachrial Nailan Azizah Roy Indrianto Bangar Runitasari Saragih Siti Khadijah