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All Journal JOPS (Journal Of Pharmacy and Science) Jurnal Buana Farma
Astriani Natalia Br Ginting
Department of Clinical Pharmacy, Faculty of Health Sciences, Universitas Prima Indonesia, Medan, 20118, Indonesia
Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Antibacterial Activity of Graded Extract of Sikkam Stem Bark (Bischofia javanica Blume) Against Staphylococcus aureus Shintjia Dewi Agustan; Vera Estefania Kaban; Astriani Natalia Br Ginting; Roy Indrianto Bangar
JURNAL FARMASI DAN MAKANAN Vol 9 No 2 (2026): Journal of Pharmacy and Science
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/jops.v9i2.7819

Abstract

Antibiotic resistance in represents a serious global health challenge, driving the search for alternative antibacterial agents from natural sources. The stem bark of the sikkam tree (Bischofia javanica Blume) has bioactive potential, yet systematic evaluation of its antibacterial activity based on solvent polarity remains limited. This study aimed to investigate the antibacterial potential of graded extracts of Sikkam stem bark against Staphylococcus aureus. Extraction was performed by graded maceration and antibacterial activity was assessed using the disc diffusion method, with amoxicillin and dimethyl sulfoxide serving as positive and negative controls, respectively. Phytochemical screening revealed the presence of phenolics, flavonoids, alkaloids, tannins, saponins, steroids/terpenoids, and quinones. Among the tested extracts, the ethyl acetate extract showed the highest yield (44.65%) and exhibited the strongest antibacterial activity, producing an inhibition zone of 13.75 ± 0.09 mm at concentration 500 mg/mL The ethanol extract also demonstrated strong and consistent inhibition zone of 12.90 ± 0.13 mm, while the n-hexane extract showed the lowest activity, with an inhibition zone of 10.86 ± 0.20 mm. This study indicates that ethyl acetate and ethanol extracts of sikkam stem bark have potential as natural antibacterial agents against Staphylococcus aureus.
EFEKTIVITAS GEL DAUN KIPAHIT (Tithonia diversifolia) TERHADAP PENYEMBUHAN LUKA DIABETES PADA TIKUS Siti Khadijah; Astriani Natalia Br Ginting; Nerly Juli Pranita Simanjuntak
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1614

Abstract

Diabetes mellitus is a chronic disease commonly associated with complications such as diabetic wounds, which are characterized by impaired tissue perfusion, prolonged inflammation, and increased susceptibility to infection, resulting in delayed wound healing. Although various topical therapies have been developed, the use of herbal-based formulations for diabetic wound management remains an area of ongoing research. Leaves of Tithonia diversifolia are known to contain secondary metabolites such as flavonoids, tannins, alkaloids, and saponins, which may support the wound healing process. This study aimed to evaluate the effectiveness of Tithonia diversifolia leaf extract gel on wound healing in streptozotocin (STZ)-induced diabetic rats. This experimental study used 30 male white rats divided into six groups: normal control, negative control (gel base), positive control (octeniline gel), and treatment groups receiving Tithonia diversifolia extract gel at concentrations of 5%, 10%, and 15%. The extract was obtained by maceration using 70% ethanol and formulated into a topical gel. Wound length was observed on days 0, 3, 7, and 14, and the data were analyzed using One-Way ANOVA followed by Tukey HSD test. The results showed that Tithonia diversifolia extract gel significantly affected wound healing from day 3 to day 14 (p < 0.05). The 10% and 15% formulations demonstrated better wound healing than the negative control, while the 15% formulation showed the most optimal result, with a mean wound length of 0.40 mm on day 14. Therefore, Tithonia diversifolia extract gel has potential to be developed as a topical preparation supporting wound healing under diabetic conditions.
UJI EFEKTIVITAS ANTIDIABETIK DAUN KIPAHIT (Tithonia diversifolia) TERHADAP KADAR GLUKOSA DARAH PADA TIKUS MODEL DIABETES TERINDUKSI STREPTOZOTOCIN Nurul Hasanah; Astriani Natalia Br Ginting; Muhammad Yunus
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1615

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. Tithonia diversifolia (Kipahit) leaves are traditionally used for diabetes. This study aims to determine the antidiabetic effectiveness of Kipahit leaf ethanol extract on blood glucose levels in streptozotocin (STZ)-induced diabetic rats. The research was an experimental laboratory study using a post-test only control group design. Thirty male rats were divided into six groups: normal control, negative control (STZ), positive control (STZ + metformin), and three treatment groups receiving the extract at doses of 250, 350, and 450 mg/kg BW. The extract yield was 29.67%. Phytochemical screening showed positive results for flavonoids, alkaloids, saponins, tannins, and steroids. Blood glucose levels were measured on days 0, 3, 6, 9, 12, and 15. Data were analyzed using One-Way ANOVA and Duncan's post hoc test. The results showed that the extract significantly reduced blood glucose levels. The dose of 450 mg/kg BW was the most effective, with an effect comparable to metformin.
UJI AKTIVITAS ANTIOKSIDAN TERHADAP EKSTRAK ETANOL DAUN MANGGA ARUM MANIS (Mangifera indica L. var. arum manis) MENGGUNAKAN METODE DPPH Siti Mahzura; Astriani Natalia Br Ginting; Daimah Wirdatus Sanaun Harahap
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1624

Abstract

Radikal bebas dapat memicu stres oksidatif yang berperan dalam berbagai penyakit degeneratif, sehingga diperlukan sumber antioksidan alami yang aman dan efektif. Daun mangga arum manis mengandung berbagai senyawa bioaktif seperti flavonoid, alkaloid, tanin, saponin, dan triterpenoid yang berpotensi sebagai antioksidan. Tujuan penelitian ini adalah mengetahui aktivitas antioksidan ekstrak etanol daun mangga arum manis (Mangifera indica L. var. arum manis) menggunakan metode DPPH (2,2-diphenyl-1-picrylhydrazyl). Metode penelitian yang digunakan adalah eksperimen laboratorium. Daun mangga dikumpulkan dari Kecamatan Secanggang, Kabupaten Langkat, kemudian dideterminasi di Herbarium Medanense. Ekstraksi dilakukan dengan metode maserasi menggunakan etanol 96%. Skrining fitokimia dilakukan untuk mengidentifikasi kandungan metabolit sekunder. Uji aktivitas antioksidan dilakukan menggunakan variasi konsentrasi ekstrak 20, 40, 60, 80, dan 100 ppm serta vitamin C sebagai kontrol positif. Sampel direaksikan dengan larutan DPPH 50 ppm dan absorbansi diukur pada panjang gelombang 517 nm setelah inkubasi 30 menit. Hasil penelitian menunjukkan bahwa persentase inhibisi meningkat seiring peningkatan konsentrasi ekstrak, dengan nilai inhibisi tertinggi sebesar 50,2% pada konsentrasi 100 ppm. Analisis regresi linear menghasilkan nilai IC₅₀ sebesar 98,73 ppm yang termasuk kategori aktivitas antioksidan kuat. Sebagai pembanding, vitamin C menunjukkan nilai IC₅₀ sebesar 6,07 ppm yang mengindikasikan aktivitas antioksidan sangat kuat. Kesimpulan penelitian ini adalah bahwa ekstrak etanol daun mangga arum manis memiliki aktivitas antioksidan kuat berdasarkan nilai IC₅₀. Meskipun potensinya lebih rendah dibandingkan vitamin C, ekstrak ini tetap menunjukkan kemampuan signifikan sebagai sumber antioksidan alami. Penelitian lanjutan disarankan menggunakan metode FRAP atau ABTS untuk memperkuat hasil.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL DAUN MANGGA ARUM MANIS (Mangifera indica L. ‘Arumanis’) TERHADAP Staphylococcus aureus Cinta Alya; Astriani Natalia Br Ginting; Daimah Wirdatus Sanaun Harahap
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1625

Abstract

The increasing prevalence of bacterial resistance to antibiotics has encouraged the exploration of natural products as alternative antimicrobial agents. This study aimed to evaluate the inhibitory potential of the ethanolic extract of ‘Arumanis’ mango leaves (Mangifera indica L. ‘Arumanis’) against Staphylococcus aureus ATCC 25923. The research was conducted using a laboratory experimental design including plant identification, preparation of simplicia, extraction by maceration with 96% ethanol, phytochemical screening, and antibacterial activity testing using the disk diffusion method. The extract was tested at concentrations of 5%, 10%, and 15% (50–150 mg/mL), with three replications (n=3) for each treatment and control group. The inhibition zones were measured including the 6 mm disk diameter and analyzed descriptively as mean ± standard deviation. Phytochemical screening revealed the presence of alkaloids, flavonoids, tannins, saponins, and triterpenoids. The antibacterial assay showed inhibition zone diameters of 3.00 ± 2.12 mm (5%), 4.38 ± 2.51 mm (10%), and 6.13 ± 2.63 mm (15%), while the positive control chloramphenicol (30 µg/disk) produced a 21.43 ± 0.06 mm inhibition zone and the negative control (10% DMSO) showed no inhibitory effect. Although inhibition zones were observed at all concentrations, the diameters were relatively small compared to the standard antibiotic. Therefore, the ethanolic extract of M. indica ‘Arumanis’ leaves demonstrates concentration-dependent inhibitory potential against S. aureus, but with limited antibacterial activity, indicating the need for further evaluation using dilution methods to determine the Minimum Inhibitory Concentration (MIC).
FORMULASI MASKER GEL DENGAN EKSTRAK DAUN MANGGA ARUMANIS (Mangifera Indica L.) SEBAGAI BAHAN AKTIF Tasyah Helgiera; Astriani Natalia Br Ginting; Roy Indrianto Bangar
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1626

Abstract

Exposure to ultraviolet (UV) radiation and environmental pollution can generate free radicals that contribute to skin damage and accelerate premature aging. One approach to protect the skin from these effects is the use of antioxidants derived from natural sources. Arumanis mango leaves (Mangifera indica L.) contain secondary metabolites such as flavonoids, tannins, and saponins which have potential antioxidant activity and can be utilized as active ingredients in cosmetic formulations. This study aimed to formulate a gel mask containing ethanol extract of arumanis mango leaves and to evaluate the physical quality of the preparation. The extract was obtained using the maceration method with 96% ethanol as the solvent. The gel mask was formulated into three different extract concentrations, namely 0%, 4%, and 6%. The physical evaluation included organoleptic test, homogeneity, pH, spreadability, and drying time tests. The results showed that the gel mask preparations exhibited good physical characteristics, with homogeneous appearance, pH values ranging from 5.16–6.26, spreadability of 5.5–6.8 cm, and drying time of 17–20 minutes. The variation in extract concentration affected the color of the preparation but did not significantly influence the overall physical stability of the gel. Therefore, ethanol extract of arumanis mango leaves can be formulated into a gel mask preparation that meets the physical quality requirements for skincare products.
UJI AKTIVITAS ANTIOKSIDAN TERHADAP DAUN BAKUNG (CRINUM ASIATICUM L.) DENGAN PELARUT ETANOL DENGAN METODE DPPH (2,2-DHIPHENYL-1-PIRCYLHYDRAZYL) Natasya Louisa; Astriani Natalia Br Ginting; Nerly July Pranita Simanjuntak; Marlina L Simbolon
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1682

Abstract

Free radicals are one of the main factors causing oxidative stress, which contributes to various degenerative diseases. Natural antioxidants derived from plants have the potential to serve as safer alternatives to synthetic antioxidants. One plant with potential as a natural antioxidant source is bakung (Crinum asiaticum L.), which has long been traditionally used, although scientific studies on it remain limited. This study aimed to determine the antioxidant activity of the ethanol extract of bakung leaves (Crinum asiaticum L.) using the DPPH method and to examine its secondary metabolite profile. This experimental research employed maceration extraction using 96% ethanol, followed by phytochemical screening to identify classes of compounds and antioxidant activity testing using the DPPH method expressed as IC₅₀ values. The results showed that the ethanol extract of bakung leaves contains alkaloids, flavonoids, tannins, saponins, and triterpenoids/steroids. The antioxidant activity test indicated that the extract exhibited strong antioxidant activity with an IC₅₀ value of 13.73 µg/mL, although it was still lower than vitamin C as the positive control, which had an IC₅₀ value of 8.56 µg/mL. Based on these findings, it can be concluded that the ethanol extract of bakung leaves (Crinum asiaticum L.) has potential as a natural antioxidant source and holds promise for further development in the fields of pharmacy and natural product chemistry.
Co-Authors Cinta Alya Daimah Wirdatus Sanaun Harahap Daimah Wirdatus Sanaun Harahap Marlina L Simbolon Muhammad Yunus Natasya Louisa Nerly Juli Pranita Simanjuntak Nerly July Pranita Simanjuntak Nurul Hasanah Roy Indrianto Bangar Roy Indrianto Bangar S Shintjia Dewi Agustan Siti Khadijah Siti Mahzura Tasyah Helgiera Vera Estefania Kaban