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Riski Dwi Utami
Departemen Biomedis, Fakultas Kedokteran, Universitas Abdurrab
Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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PENGARUH GEL PUTIH TELUR BEBEK TERHADAP PENYEMBUHAN LUKA INSISI PADA MENCIT DIABETES Mahendra Mahendra; Dwi Jayanti; Riski Dwi Utami; Olvaria Misfa; May Valzon
Collaborative Medical Journal Vol 8 No 1 (2025): Januari 2025
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/cmj.v8i1.5809

Abstract

The International Diabetes Federation (IDF) in 2019 stated that around 463 million people aged 20-79 years in the world suffer from diabetes mellitus. Indonesia is ranked seventh in the world suffering from diabetes mellitus. The highest wound prevalence in the world is incision wounds with a prevalence of 48%. Diabetes mellitus can inhibit the healing of incision wounds, because it increases the risk of infection due to impaired metabolic activity. Egg white is one of the traditional ingredients that can be used to heal incision wounds. In this study, duck egg white was used to see the effect of duck egg white gel on healing incision wounds in diabetic mice. This study is an experimental study with a post-test only with control group design with 16 mice divided into a positive control group, a negative control group, treatment group 1 with 10% duck egg white gel and treatment group 2 with 20% duck egg white gel. The treatment in the form of mice injected with alloxan 0.05 ml/head and incised on the back of the mouse with a length of 1 cm and a depth of 0.2 cm and the measurement of the remaining wound length using a caliper on days 3, 5, 7, and 14. Based on the One Way Anova test on days 3, 5, 7, and 14, a p value <0.05 was obtained which indicated that duck egg white gel with a concentration of 10% and 20% was effective in accelerating the healing of incision wounds in mice. Duck egg white gel with a concentration of 20% had the most adequate effectiveness in healing incision wounds in diabetic mice. Based on this study, administration of duck egg white gel with a concentration of 10% and 20% was effective in healing incision wounds in diabetic mice.
PENGARUH PEMBERIAN JUS BONGGOL NANAS (ANANAS COMOSUS (L.) MERR) TERHADAP KADAR GLUKOSA TIKUS PUTIH JANTAN (RATTUS NORVEGICUS) YANG DIINDUKSI ALOKSAN Santi Widiasari; Muhammad Habib Miftah Al-basyari; Eva Oktariani; Riski Dwi Utami; Wahyu Ramadhan
Collaborative Medical Journal Vol 8 No 1 (2025): Januari 2025
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/cmj.v8i1.5810

Abstract

Diabetes Mellitus (DM) is a chronic metabolic disease characterized by increased blood glucose levels, which over time can cause damage to the heart, blood vessels, eyes, kidneys and nerves. Some plants that are known to lower blood glucose levels are pineapple, which contains flavonoids in the pineapple tuber. Flavonoid compounds are known to have strong antioxidant activity. By giving pineapple tuber juice, it is hoped that it can reduce blood glucose levels, one of which is by regenerating damaged pancreatic beta cells and stimulating pancreatic beta cells to produce insulin. The aim of this study was to determine the effect of giving pineapple tuber (Ananas comosus (L.) Merr) juice on the glucose levels of male white rats (Rattus norvegicus) induced by alloxan. This research method is experimental research that uses a "pretest - posttest with control group design". The samples used were 20 male Wistar rats. The mice were divided into 5 treatment groups consisting of a normal group, a negative control group which was induced by alloxan, a positive group which was given metformin, and a group which was given 100% and 50% concentrations of pineapple tuber juice. The results of this study through One Way ANOVA analysis showed that giving pineapple tuber juice with concentrations of 100% and 50% had a significant blood glucose reduction effect of p<0.05 in the negative control group. There was no significant difference p>0.05 between 100% and 50% concentrations of the positive control given metformin. The greatest decrease in blood sugar occurred at a concentration of 100%. The conclusion of this research is that pineapple tuber juice (Ananas comosus L. Merr) can reduce blood glucose levels in rats induced by alloxan with the largest reduction at a concentration of 100%.
Co-Authors Dwi Jayanti Eva Oktariani Mahendra Mahendra May Valzon Muhammad Habib Miftah Al-basyari Olvaria Misfa Santi Widiasari Wahyu Ramadhan