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All Journal Medfarm: Jurnal Farmasi dan Kesehatan Unesa Journal of Chemistry
Subhan Rullyansyah
Universitas Negeri Surabaya
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Energy Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Uji Efektifitas Ekstrak Etanol 70% Herba Pegagan (Centella asiatica (L.) Urb.) Sebagai Peningkat Nafsu Makan Secara in vivo: Effectiveness Test of 70% Ethanol Extract of Gotu Kola Herb (Centella asiatica (L.) Urb.) as an Appetite Stimulant in vivo Fajar Sandhori; Yusuf Alif Pratama; Hanif Rifqi Prasetyawan; Subhan Rullyansyah; Firmansyah Ardian Ramadhani
Unesa Journal of Chemistry Vol. 15 No. 1 (2026): Vol 15 No 1
Publisher : Department of Chemistry, Faculty of Mathematics and Natural Sciences, Surabaya State University, located at Jl Ketintang, Surabaya, East Java, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26740/ujc.v14n3.p97-103

Abstract

Centella asiatica (L.) Urb. contain bioactive compounds such as triterpenoids, flavonoids, and phenolics with antioxidant activity that can increase appetite through an indirect orexigenic effect. This study aimed to evaluate the antioxidant activity and the effectiveness of the extract as an appetite enhancer in vivo. Extraction was performed using the Microwave-Assisted Extraction (MAE) method. Antioxidant activity was assessed using the DPPH method at a maximum wavelength of 517 nm. The in vivo study was conducted on male BALB/c mice divided into four groups (control, 100 mg/kg BW, 200 mg/kg BW, and 400 mg/kg BW). The results showed that the extract exhibited antioxidant activity with an IC₅₀ value of 50.16 ± 3.24 ppm, which was weaker than vitamin C (8.15 ± 0.72 ppm) . Appetite stimulation testing demonstrated increased feed intake at doses of 200 mg/kg BW (3.25 ± 0.36 g) and 400 mg/kg BW (3.88 ± 0.44 g) compared to the control (2.34 ± 0.43 g) and each group showed significant differences (p<0.05). These findings indicate that the 70% ethanol extract of Centella asiatica possesses moderate antioxidant activity and potential appetite-enhancing effects at specific dosages.
Antibacterial Activity of Siam Weed Extract (Chromolaena odorata L.) Against Streptococcus mutans and Pseudomonas aeruginosa Bacteria I Putu Gede Adi Purwa Hita; Putu Padmidewi Wijaya Kusuma; Subhan Rullyansyah; Bagus Lanang Arinatha
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.645

Abstract

Infectious diseases are one of the main health problems in developed and developing countries. The prevalence of nosocomial infections reaches 15.74% and dental caries infections reach 88.8% caused by Pseudomonas aeruginosa and Streptocuccus mutans bacteria. To overcome bacterial infections, people usually use antibiotics, however, the use of antibiotics that are not appropriate and appropriate to the indications can cause antibiotic resistance or Antimicrobial Resistance (AMR). Therefore, this study aims to test the effectiveness of siam weed leaf extract (Chromolaena odorata L.) in inhibiting the growth of bacteria that cause infections. Siam weed leaf extract was prepared using the maceration method with 96% ethanolic solvent accompanied by extract quality control and active compound content testing. Antibacterial activity testing was carried out using the disc diffusion method to see and measure the area of inhibition zone. The results founded that siam extract has good water content, total ash content and weed acid insoluble ash content, which are below 10%, 16.6% and 0.7%. The antibacterial activity test of siam weed leaf extract obtained an inhibition zone diameter of 15.1 mm in Streptococcus mutans bacteria and 18.2 mm in Pseudomonas aeruginosa. In addition, siam weed extract also qualitatively contains active secondary metabolite compounds such as alkaloids, flavonoids, saponins, steroids, phenols and tannins. This concluded that siam weed leaves extract of has a characteristics that meet the requirements, containing secondary metabolite compounds and has antibacterial activity against the growth of Pseudomonas aeruginosa and Streptococcus mutans bacteria.
Co-Authors Bagus Lanang Arinatha Fajar Sandhori Firmansyah Ardian Ramadhani Hanif Rifqi Prasetyawan I Putu Gede Adi Purwa Hita Putu Padmidewi Wijaya Kusuma Yusuf Alif Pratama